The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response
Open accessAbstract
We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced by human mycobacterial infection. Remarkably, >20% of specific cytokine-producing CD4+ T cells in peripheral blood of healthy, mycobacteria-exposed adults expressed IL-17 or IL-22. Specific IL-17- and IL-22-producing CD4+ T cells were distinct from each other and from Th1 cytokine-producing cells. These cells had phenotypic characteristics of long-lived central memory cells. In patients with tuberculosis disease, peripheral blood frequencies of these cells were reduced, whereas bronchoalveolar lavage fluid contained higher levels of IL-22 protein compared with healthy controls. IL-17 was not detected in this fluid, which may be due to suppression by Th1 cytokines, as PBMC IL-17 production was inhibited by IFN-γ in vitro. However, Th1 cytokines had no effect on IL-22 production in vitro. Our results imply that the magnitude and complexity of the anti-mycobacterial immune response have historically been underestimated. IL-17- and IL-22-producing CD4+ T cells may play important roles in the human immune response to mycobacteria.
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“CCR7 expression endows Ag-experienced CD45RA T cells with the potential for lymph node homing, which is characteristic of central memory cells, whereas absence of CCR7 expression allows migration to the site of infection, which is typical of effector cells (50).”
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Transforming growth factor-β induces development of the TH17 lineage
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Phenotypic and functional features of human Th17 cells
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“different, requiring IL-1 in addition to IL-6 (21, 55).”
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Cited by
Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
Ouyang, W., Rutz, S., Crellin, N. K., Valdez, P. A., & Hymowitz, S. G. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101312 · Cited by 1,925
Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
HIV and Tuberculosis: a Deadly Human Syndemic
Kwan, C. K., & Ernst, J. D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-10 · Cited by 720
Interleukin‐17 in host defence against bacterial, mycobacterial and fungal pathogens
Curtis, M. M., & Way, S. S. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.03017.x · Cited by 502
Khader, S. A., Gaffen, S. L., & Kolls, J. K. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.100 · Cited by 481
Metadata
- Authors
- Scriba, T. J., Kalsdorf, B., Abrahams, D.-A., Isaacs, F., Hofmeister, J., Black, G., Hassan, H. Y., Wilkinson, R. J., Walzl, G., Gelderbloem, S. J., Mahomed, H., Hussey, G. D., & Hanekom, W. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02-01
- Volume
- 180
- Issue
- 3
- Pages
- 1962-1970
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1646851899
- Cited by
- 410
- References
- 14
- FWCI
- 27.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Scriba, T. J., Kalsdorf, B., Abrahams, D.-A., Isaacs, F., Hofmeister, J., Black, G., Hassan, H. Y., Wilkinson, R. J., Walzl, G., Gelderbloem, S. J., Mahomed, H., Hussey, G. D., & Hanekom, W. A. (2008). Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response. The Journal of Immunology. https://doi.org/10.4049/jimmunol.180.3.1962
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
