The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis
Open accessAbstract
Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also associated with multiple comorbid conditions, such as joint destruction, cardiovascular disease, stroke, hypertension, metabolic syndrome, and chronic kidney disease. The discovery of IL-17–producing T cells in a mouse model of autoimmunity transformed our understanding of inflammation driven by T lymphocytes and associations with human inflammatory diseases, such as psoriasis. Under the regulation of IL-23, T cells that produce high levels of IL-17 create a self-amplifying, feed-forward inflammatory response in keratinocytes that drives the development of thickened skin lesions infiltrated with a mixture of inflammatory cell populations. Recently, the Food and Drug Administration approved multiple highly effective psoriasis therapies that disrupt IL-17 (secukinumab, ixekizumab, and brodalumab) and IL-23 (guselkumab and tildrakizumab) signaling in the skin, thus leading to a major paradigm shift in the way that psoriatic disease is managed.
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Cites
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Cited by
Advances in the pathogenesis of psoriasis: from keratinocyte perspective
Zhou, X., Chen, Y., Cui, L., Shi, Y., & Guo, C. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04523-3 · Cited by 632
Resident Memory T Cells in Autoimmune Skin Diseases
Ryan, G. E., Harris, J. E., & Richmond, J. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.652191 · Cited by 132
Immune-mediated inflammatory diseases: common and different pathogenic and clinical features
Monteleone, G., Moscardelli, A., Colella, A., Marafini, I., & Salvatori, S. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103410 · Cited by 105
Martínez, B. A., Shrotri, S., Kingsmore, K. M., Bachali, P., Grammer, A. C., & Lipsky, P. E. (2022) · Science Advances · doi:10.1126/sciadv.abn4776 · Cited by 56
“To date, TNF-neutralizing agents are effective in treating PSO ( 26 ) [etanercept ( 54 ), infliximab ( 55 ), adalimumab ( 56 ), and certolizumab pegol ( 57 )], whereas others report their possible efficacy in SLE ( 58 ) and AD ( 59 , 60 ).”
Review of bimekizumab in the treatment of psoriasis
Koppu, S., Singh, R., Kaur, K., & Feldman, S. R. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2119767 · Cited by 11
Metadata
- Authors
- Hawkes, J. E., Yan, B. Y., Chan, T. C., & Krueger, J. G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-09
- Volume
- 201
- Issue
- 6
- Pages
- 1605-1613
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2890147164
- Cited by
- 593
- References
- 85
- FWCI
- 17.35
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis. https://app.cochat.ai/papers/10.4049/jimmunol.1800013
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- Hawkes, J. E., Yan, B. Y., Chan, T. C., & Krueger, J. G. (2018). Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1800013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
