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Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes
Open accessAbstract
Monocytes play a central role in the immunopathological effects of sepsis. This role is mediated by production of the cytokines TNF-α and IL-1β. The transcription factor NF-E2-related factor 2 (Nrf2) regulates innate immune responses in various experimental disease models. Presently, the role of Nrf2-regulated genes in LPS-treated human monocytes is not well defined. Herein we show that Nrf2 mediates a significant regulation of LPS-induced inflammatory responses. Analysis of Nrf2-regulated gene expression in human monocytes showed that LPS induced the expression of the phase II detoxification gene NAD(P)H:quinone oxidoreductase 1 (NQO1). Furthermore, NQO1 mRNA or protein expression in response to LPS was regulated by Nrf2. Silencing Nrf2 expression in human monocytes inhibited LPS-induced NQO1 expression; however, in contrast, it significantly increased TNF and IL-1β production. Silencing expression of NQO1 alone, or in combination with heme oxygenase-1 (HO-1) silencing, markedly increased LPS-induced TNF and IL-1β expression. Additionally, overexpression of NQO1 and/or HO-1 inhibited LPS-induced TNF and IL-1β expression. These results show for the first time that LPS induces NQO1 and HO-1 expression in human monocytes via Nrf2 to modulate their inflammatory responsiveness, thus providing novel potential therapeutic strategies for the treatment of sepsis.
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“Nrf2 plays a role in regulating the anti-inflammatory response through redox control and activation of ARE-mediated anti-inflammatory genes, including the expression of the antioxidant genes NQO1, HO-1, and PRX1, all of which exhibit anti-inflammatory effects [191,192,193,194].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [193]
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Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Targeting the KEAP1-NRF2 system to prevent kidney disease progression
Nezu, M., Suzuki, N., & Yamamoto, M. (2017) · American Journal of Nephrology · doi:10.1159/000475890 · Cited by 3,447
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742
The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration
Mogensen, C. E. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516809076979 · Cited by 2,654
The Prevalence of Nosocomial Infection in Intensive Care Units in Europe
Vincent, J. (1995) · JAMA · doi:10.1001/jama.274.8.639 · Cited by 2,592
LPS induction of gene expression in human monocytes
Guha, M., & Mackman, N. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(00)00149-2 · Cited by 2,333
Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,473
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Clapper, E., Trapani, G. D., & Tonissen, K. F. (2021) · Hemato · doi:10.3390/hemato2020014
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Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-88460-0.00012-6
Faculty Opinions recommendation of Transcriptional regulation by nrf2.
Ji, L. L. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731119952.793582094
Aguilera, A. C. A., Mónaco, M. E., Lazarte, S. S., Achem, E. L., Asensio, N. S. Á., Terán, M. M., Issé, B. A., Marcela, M., & Haro, C. (2024) · Journal of Hematology and Clinical Research · doi:10.29328/journal.jhcr.1001029
Mateos, R. N., Winardi, W., Chiba, K., Okada, A., Suzuki, A., Mitsuishi, Y., & Shiraishi, Y. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00475-w
König, A., Sandner, G., Klanert, G., Pühringer, L., Karimian, T., Schurr, J., Syriopoulos, K., Tona, R., & Weghuber, J. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100501
Therapeutic Potential of Ozonized Glycerin in Skin Inflammation and Repair
Ivarsson, J., Guiotto, A., Trinchera, G., Pecorelli, A., Shiota, G., & Valacchi, G. (2026) · Cosmetics · doi:10.3390/cosmetics13010042
TBK1-NQO1 negative feedback loop regulates antiviral innate immunity
Lee, H., Weerawardhana, A., Chathuranga, K., Chathuranga, W. A. G., Kim, T.-H., Jang, D., Chen, A., Schaffer, D. V., Jung, J. U., Lee, C., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02850-y
Deciphering the immune response to respiratory pathogens - Role of programmed death-ligand 1
Victor, E. S. (2016) · theses.fr (ABES) · doi:10.70675/42f25aeez159bz4bf3z8f30z05634e3e8152
The regulatory effects of circulating normal immunoglobulins on autophagy and Th17 response
Das, M. (2017) · theses.fr (ABES) · doi:10.70675/ea6bb914zc789z45bez864fz4c3386135691 · Cited by 2
Zhou, J., Xu, C., Gu, C., Zhou, Q., Wang, H., Su, H., Zhou, M., Zhu, Q., Huang, G., & Xu, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1893871
Tognarelli, E. I., Cornejo, D. A., del Campo, E. J., Reyes-Ramírez, R., Ortiz, G. E., Gaete-Argel, A., Kalergis, A. M., Bueno, S. M., Carreño, L. J., Soto‐Rifo, R., et al. (2026) · Antiviral Research · doi:10.1016/j.antiviral.2026.106545
Yokobori, N. K. (2010) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Metadata
- Authors
- Rushworth, S. A., MacEwan, D. J., & O’Connell, M. A.
- Affiliations
- University of East Anglia (GB)
- School of Chemical Sciences and Pharmacy, University of East Anglia , Norwich,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-11
- Volume
- 181
- Issue
- 10
- Pages
- 6730-6737
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC2923058
- OpenAlex
- W2105691693
- Cited by
- 215
- References
- 51
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 12 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 18 · 2019: 11 · 2018: 8 · 2017: 14 · 2016: 8 · 2015: 16 · 2014: 17 · 2013: 13 · 2012: 11
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- University of East Anglia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- lipopolysaccharide, NAD(P)H:quinone oxidoreductase 1, heme oxygenase-1, Nrf2, human monocytes, sepsis, inflammation, TNF-α, IL-1β, innate immunity
- MeSH terms
- Cell Line, Gene Expression Regulation, Humans, Inflammation, Lipopolysaccharides, Monocytes, RNA, Messenger, Tumor Necrosis Factor-alpha, Gene Expression, NAD(P)H Dehydrogenase (Quinone), Reactive Oxygen Species, Sepsis, Reverse Transcriptase Polymerase Chain Reaction, Gene Silencing, NF-E2-Related Factor 2, Heme Oxygenase-1, Interleukin-1beta
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