The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-β Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

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5. TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells
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7. Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting TH1/TH17 cell differentiation in patients with inflammatory bowel diseases
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8. Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression
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9. TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination
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11. Putting the brakes on the anti-viral response: negative regulators of type I interferon (IFN) production
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12. Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice
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13. Hantavirus GnT Elements Mediate TRAF3 Binding and Inhibit RIG-I/TBK1-Directed Beta Interferon Transcription by Blocking IRF3 Phosphorylation
    Valery S. Matthys, Velasco Cimica, Nadine A. Dalrymple, Nicole B. Glennon, Chris Bianco, Erich R. Mackow · 2014 · Journal of Virology
14. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production
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15. c-Cbl-mediated ubiquitination of IRF3 negatively regulates IFN-β production and cellular antiviral response
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18. Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response
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19. E3 ubiquitin ligases, the powerful modulator of innate antiviral immunity
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20. TRIM11 Negatively Regulates IFNβ Production and Antiviral Activity by Targeting TBK1
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21. Ubiquitination Regulates Expression of the Serine/Arginine-rich Splicing Factor 1 (SRSF1) in Normal and Systemic Lupus Erythematosus (SLE) T Cells
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22. Caspase-8-mediated Cleavage Inhibits IRF-3 Protein by Facilitating Its Proteasome-mediated Degradation
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25. E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation
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28. SARS-CoV-2 Spike Antagonizes Innate Antiviral Immunity by Targeting Interferon Regulatory Factor 3
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29. Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage
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30. Degradation of WTAP blocks antiviral responses by reducing the m6A levels of IRF3 and IFNAR1 mRNA
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31. Intracellular Antiviral Immunity
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32. TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis
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33. The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases
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34. TRIM21 Mitigates Human Lung Microvascular Endothelial Cells’ Inflammatory Responses to LPS
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36. Transcriptional and Non-Transcriptional Activation, Posttranslational Modifications, and Antiviral Functions of Interferon Regulatory Factor 3 and Viral Antagonism by the SARS-Coronavirus
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37. Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon
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38. Tyrosine Phosphorylation of the E3 Ubiquitin Ligase TRIM21 Positively Regulates Interaction with IRF3 and Hence TRIM21 Activity
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39. Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta
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42. The Evolution and Functional Diversification of the Deubiquitinating Enzyme Superfamily
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43. Enhanced interferon regulatory factor 3 binding to the interleukin‐23p19 promoter correlates with enhanced interleukin‐23 expression in systemic lupus erythematosus
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44. A systematic view on E3 ligase Ring TRIMmers with a focus on cardiac function and disease
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46. RING Finger Protein 11 Targets TBK1/IKKi Kinases to Inhibit Antiviral Signaling
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47. TRIMming Type I Interferon-Mediated Innate Immune Response in Antiviral and Antitumor Defense
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48. TRIM35 negatively regulates TLR7‐ and TLR9‐mediated type I interferon production by targeting IRF7
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49. Ductal epithelial expression of Ro52 correlates with inflammation in salivary glands of patients with primary Sjögren's syndrome
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50. Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization
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54. Deubiquitylating enzymes: potential target in autoimmune diseases
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55. Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting
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56. Fine-tuning of antiviral innate immunity by ubiquitination
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57. TRIM21 Is Targeted for Chaperone-Mediated Autophagy during Salmonella Typhimurium Infection
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59. A Broader Perspective on Anti-Ro Antibodies and Their Fetal Consequences—A Case Report and Literature Review
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60. Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction
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61. Proteomics Analysis of EV71-Infected Cells Reveals the Involvement of Host Protein NEDD4L in EV71 Replication
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62. The Sjögren's syndrome-associated autoantigen Ro52/TRIM21 modulates follicular B cell homeostasis and immunoglobulin production
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64. Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy
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72. Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus
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74. EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail
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75. The Pestivirus N Terminal Protease Npro Redistributes to Mitochondria and Peroxisomes Suggesting New Sites for Regulation of IRF3 by Npro
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76. Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators
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77. Ro52/TRIM21-deficient expression and function in different subsets of peripheral blood mononuclear cells is associated with a proinflammatory cytokine response in patients with idiopathic inflammatory myopathies
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78. Autoantibodies against the Immunoglobulin-Binding Region of Ro52 Link its Autoantigenicity with Pathogen Neutralization
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81. Intracellular Antibody Immunity and the Cytosolic Fc Receptor TRIM21
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82. The suppression of TRIM21 and the accumulation of IFN-α play crucial roles in the pathogenesis of osteonecrosis of the femoral head
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