The DOI matches its Crossref record.
Physico-Chemical Properties of Human Reaginic Antibody
Abstract
Summary: The reaginic activity in sera from ragweed-sensitive patients was inactivated after the precipitation of serum proteins with the rabbit antihuman globulin serum which did not contain any of the antibodies specific for γG-, γA-, γM-globulins and for light chains of immunoglobulins. The rabbit antiserum gave a γ1-globulin precipitin band with the reagin-containing fraction which contained γA but none of the γG-, γM- or γD-globulins. The specificity of the precipitin band was different from the γA-anti-γA band. By radioimmunoelectrophoresis and by radioimmunodiffusion, the antibody against ragweed pollen-extract (antigen E) was detected in the γ1-globulin, indicating the presence of a unique γ1-immunoglobulin. The protein was tentatively designated γE-globulin. Precipitation of γE-globulin anti-ragweed antibody in the reagincontaining fraction was accompanied by the loss of reaginic activity, whereas the precipitation of the γA-globulin antibody in the fraction did not result in any decrease of reaginic activity. The results highly suggest that the reaginic activity is associated with γE-globulin.
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Citations
Cited by
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Bernstein, I. L., Li, J. T., Bernstein, D. I., Hamilton, R., Spector, S. L., Tan, R., Sicherer, S., Golden, D. B. K., Khan, D. A., Nicklas, R. A., et al. (2008) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)60305-5 · Cited by 723
VALENTA, LIDHOLM, NIEDERBERGER, HAYEK, KRAFT, & GRÖNLUND (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00653.x · Cited by 531
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Cookson, W. O. C. M., Young, R. P., Sandford, A. J., Moffatt, M. F., Shirakawa, T., Sharp, P. A., Faux, J. A., Le Souef, P. N., Julier, C., Lathrop, G. M., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)91468-n · Cited by 342
Metadata
- Authors
- Ishizaka, K., Ishizaka, T., & Hornbrook, M. M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1966-07-01
- Volume
- 97
- Issue
- 1
- Pages
- 75-85
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313376209
- Cited by
- 385
- References
- 0
- FWCI
- 31.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ishizaka, K., Ishizaka, T., & Hornbrook, M. M. (1966). Physico-Chemical Properties of Human Reaginic Antibody. The Journal of Immunology. https://doi.org/10.4049/jimmunol.97.1.75
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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