The Importance of GLWamide Neuropeptides in Cnidarian Development and Physiology
Open accessAbstract
The peptide-signaling molecules (<50 amino acid residues) occur in a wide variety of invertebrate and vertebrate organisms, playing pivotal roles in physiological, endocrine, and developmental processes. While some of these peptides display similar structures in mammals and invertebrates, others differ with respect to their structure and function in a species-specific manner. Such a conservation of basic structure and function implies that many peptide-signaling molecules arose very early in the evolutionary history of some taxa, while species-specific characteristics led us to suggest that they also acquire the ability to evolve in response to specific environmental conditions. In this paper, we describe GLWamide-family peptides that function as signaling molecules in the process of muscle contraction, metamorphosis, and settlement in cnidarians. The peptides are produced by neurons and are therefore referred to as neuropeptides. We discuss the importance of the neuropeptides in both developmental and physiological processes in a subset of hydrozoans, as well as the potential use as a seed compound in drug development and aspects related to the protection of corals.
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Two smaller neuronal subpopulations expressing RFamide and GLWamide are primarily found in the oral half of the young polyp.
“Two smaller neuronal subpopulations expressing specific neuropeptides, RFamide and GLWamide [30,31], are primarily found in the oral half of the young polyp.”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [31]
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- Authors
- Takahashi, T., & Hatta, M.
- Affiliations
- Suntory Foundation for Life Sciences (JP)
- Ochanomizu University (JP)
- Corresponding author
- Takahashi, Toshio
- Venue
- Journal of Amino Acids
- Publisher
- Hindawi Limited
- Published
- 2011-10-20
- Volume
- 2011
- Pages
- 1-8
- ISSN
- 2090-0104 (ISSN-L)
- 2090-0112
- PMC
- PMC3268022
- OpenAlex
- W2086410253
- Cited by
- 31
- References
- 25
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 2 · 2017: 5 · 2015: 4 · 2014: 1 · 2013: 2
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Amino Acids (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- neuropeptides, cnidarian development, Hydrozoa, peptide signaling, muscle contraction, metamorphosis, settlement, drug development, neuropeptide evolution
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