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Cited by 22Parkinson's Disease Mechanisms and TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

The Role of Cognitive-Behavioural Therapy for Patients with Depression in Parkinson's Disease

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Charidimou, Andreas, Seamons, John, Selai, Caroline, Schrag, Anette·2011·Parkinson's Disease
DOI 10.4061/2011/737523PMC PMC3135065
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Abstract

Depression is a common complication of Parkinson's disease (PD) with considerable impact on patients' quality of life. However, at present the most appropriate treatment approach is unclear. There are limited data on antidepressant medications in PD-associated depression (dPD) and those available suggest limited efficacy and tolerability of these drugs. Cognitive behavioural therapy (CBT) has been shown to be an effective treatment of depressive disorders. Treatment of dPD with CBT may pose particular challenges, including possible different pathophysiology, physical and mental comorbidities, and barriers to treatment through disability, which do not allow simple transfer of these results to patients with dPD. However, a number of case reports, case series, and small pilot studies suggest that this is a promising treatment for patients with PD. We here summarise the published evidence on this treatment in dPD.

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  • A reduction of anxiety symptoms in patients with Parkinson's disease is observed in most CBT studies.

    “A reduction of anxiety symptoms in patients with PD is observed in most of the CBT studies [24–26].”

    From BEWARE: Body awareness training in the treatment of wearing-off related anxiety in patients with Parkinson's disease: study protocol for a randomized controlled trial. (2015) · cites this paper as [25]

    The Results (section 3.1; page unavailable) report improved anxiety scores in a small CBT pilot study and greater anxiety improvement in a CBT group than in a support group. Section 3.2 also describes reduced anxiety in one case study. The Discussion (section 4; page unavailable) says most of the 15 studies reported improvements in depressive symptoms, not anxiety, so the claim that most CBT studies observed reduced anxiety is not established. (LLM, conf=0.86)

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Cited by

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Authors
Charidimou, A., Seamons, J., Selai, C., & Schrag, A.
Affiliations
  • National Hospital for Neurology and Neurosurgery (GB)
  • The Royal Free Hospital (GB)
Corresponding author
Schrag, Anette
ORCID
Venue
Parkinson's Disease
Publisher
Wiley
Published
2011
Volume
2011
Pages
1-8
ISSN
2042-0080 (ISSN-L)
DOI
10.4061/2011/737523
PMC
PMC3135065
OpenAlex
W2061491699
Cited by
22
References
6
Citations by year
2025: 2 · 2024: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
1.83
Type
journal article
Language
en
Open access
Licence
Locations
  • Parkinson s Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
cognitive behavioral therapy, depression, depression in Parkinson's disease, antidepressant treatment, quality of life, comorbidities, barriers to treatment, treatment efficacy

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