The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective
Open accessAbstract
The incidence of cerebrovascular disease is highest in the elderly population. However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. Ischemic changes in the commonly used young animal stroke models do not reflect the molecular changes associated with the aged brain. Neuroinflammation and oxidative stress are important pathogenic processes occurring during the acute phase of cerebral ischemia. Free radical generation is also implicated in the aging process, and the combination of these effects in elderly stroke patients could explain the higher risk of morbidity and mortality. A better understanding of stroke pathophysiology in the elderly patient would assist in the development of new therapeutic strategies for this vulnerable age group. With the increasing use of reperfusion therapies, inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents. This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective.
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Cites
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BackgroundInterleukin-1 and neuronal injury
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Cited by
Creswell, J. D., Irwin, M. R., Burklund, L. J., Lieberman, M. D., Arevalo, J. M. G., Ma, J., Breen, E. C., & Cole, S. W. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.006 · Cited by 607
Cognitive training for people with mild to moderate dementia
Bahar-Fuchs, A., Martyr, A., Goh, A. M., Sabates, J., & Clare, L. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013069.pub2 · Cited by 342
Cai, W., Zhang, K., Li, P., Zhu, L., Xu, J., Yang, B., Hu, X., Lu, Z., & Chen, J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.006 · Cited by 285
Khedher, L., Ramírez, J., Górriz, J. M., Brahim, A., & Segovia, F. (2015) · Neurocomputing · doi:10.1016/j.neucom.2014.09.072 · Cited by 262
Finger, D., Goltz, F. R., Umpierre, D., Meyer, E., Rosa, L. H. T., & Schneider, C. D. (2015) · Sports Medicine · doi:10.1007/s40279-014-0269-4 · Cited by 185
Metadata
- Authors
- Di Napoli, M., & Shah, I. M.
- Venue
- Journal of Aging Research
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-18
- ISSN
- 2090-2204 (ISSN-L)
- 2090-2212
- OpenAlex
- W2152560614
- Cited by
- 263
- References
- 221
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
