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Cited by 118Parkinson's Disease Mechanisms and TreatmentsUrinary Bladder and Prostate ResearchPelvic floor disorders treatments

Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease

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Sakakibara, Ryuji, Kishi, Masahiko, Ogawa, Emina, Tateno, Fuyuki, Uchiyama, Tomoyuki, Yamamoto, Tatsuya, Yamanishi, Tomonori·2011·Parkinson's Disease
DOI 10.4061/2011/924605PMC PMC3171780
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Abstract

Bladder dysfunction (urinary urgency/frequency), bowel dysfunction (constipation), and sexual dysfunction (erectile dysfunction) (also called “pelvic organ” dysfunctions) are common nonmotor disorders in Parkinson's disease (PD). In contrast to motor disorders, pelvic organ autonomic dysfunctions are often nonresponsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine-basal ganglia circuit, which normally suppresses the micturition reflex. By contrast, peripheral myenteric pathology causing slowed colonic transit (loss of rectal contractions) and central pathology causing weak strain and paradoxical anal sphincter contraction on defecation (PSD, also called as anismus) are responsible for the bowel dysfunction. In addition, hypothalamic dysfunction is mostly responsible for the sexual dysfunction (decrease in libido and erection) in PD, via altered dopamine-oxytocin pathways, which normally promote libido and erection. The pathophysiology of the pelvic organ dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis. Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline. Dietary fibers, laxatives, and “prokinetic” drugs such as serotonergic agonists are used to treat bowel dysfunction in PD. Phosphodiesterase inhibitors are used to treat sexual dysfunction in PD. These treatments might be beneficial in maximizing the patients' quality of life.

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  • Erectile dysfunction is common in males with Parkinson's disease.

    “Erectile dysfunction is common in males (Sakakibara et al. 2011).”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Sakakibara et al. 2011

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200 of 251 shown

Authors
Sakakibara, R., Kishi, M., Ogawa, E., Tateno, F., Uchiyama, T., Yamamoto, T., & Yamanishi, T.
Affiliations
  • Toho University (JP)
  • Chiba University (JP)
  • Dokkyo Medical University (JP)
Corresponding author
Sakakibara, Ryuji
ORCID
Venue
Parkinson's Disease
Publisher
Wiley
Published
2011
Volume
2011
Pages
1-21
ISSN
2042-0080 (ISSN-L)
DOI
10.4061/2011/924605
PMC
PMC3171780
OpenAlex
W2034698488
Cited by
118
References
250
Citations by year
2026: 3 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 3 · 2020: 18 · 2019: 12 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 13 · 2014: 13 · 2013: 7 · 2012: 6
FWCI
5.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Parkinson s Disease (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
  • Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
Keywords
bladder dysfunction, bowel dysfunction, sexual dysfunction, non-motor symptoms, urinary urgency and frequency, constipation, erectile dysfunction, anismus, micturition reflex, colonic transit, hypothalamic dysfunction, multiple system atrophy, anticholinergic agents, prokinetic drugs, phosphodiesterase inhibitors, levodopa resistance

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