LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

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Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells

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A Pituitary-Derived MEG3 Isoform Functions as a Growth Suppressor in Tumor Cells

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MALAT‐1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility‐related genes

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Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q

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Maternally Expressed Gene 3 (MEG3) Noncoding Ribonucleic Acid: Isoform Structure, Expression, and Functions

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Roots of Clinical Resistance to STI-571 Cancer Therapy

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The Noncoding RNA Expression Profile and the Effect of lncRNA AK126698 on Cisplatin Resistance in Non-Small-Cell Lung Cancer Cell

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Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management

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The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma

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TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21

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First-line treatment for chronic myeloid leukemia: dasatinib, nilotinib, or imatinib

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Functionalized Graphene Oxide Mediated Adriamycin Delivery and miR-21 Gene Silencing to Overcome Tumor Multidrug Resistance In Vitro

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Gene silencing by DNA methylation in haematological malignancies

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Downregulation of miR-21 Enhances Chemotherapeutic Effect of Taxol in Breast Carcinoma Cells

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Long Noncoding RNAs in Human Disease: Emerging Mechanisms and Therapeutic Strategies

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MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3

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BCR-ABL1 mutation development during first-line treatment with dasatinib or imatinib for chronic myeloid leukemia in chronic phase

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Mechanism of Cancer Drug Resistance and the Involvement of Noncoding RNAs

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Molecular mechanisms of resistance of leukemia to imatinib mesylate

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Therapeutic Drug Monitoring of Imatinib for Chronic Myeloid Leukemia Patients in the Chronic Phase

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microRNA expression profiling as supportive diagnostic and therapy prediction tool in chronic myeloid leukemia

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Identification of Drug Combinations Containing Imatinib for Treatment of BCR-ABL+ Leukemias

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Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies

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Protein-coding genes and long noncoding RNAs are differentially expressed in dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib

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A Multi-centric Bioequivalence Trial in Ph+ Chronic Myeloid Leukemia Patients to Assess Bioequivalence and Safety Evaluation of Generic Imatinib Mesylate 400 mg Tablets

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Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway

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Long noncoding RNAs in cancer cells

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Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA

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Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

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Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs

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LncRNA MEG3 inhibits cell epithelial-mesenchymal transition by sponging miR-421 targeting E-cadherin in breast cancer

Zhang, W., Shi, S., Jiang, J., Li, X., Lu, H., & Ren, F. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.085 · Cited by 124 · see citing works

LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis

Wang, P., Chen, D., Ma, H., & Li, Y. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s146423 · Cited by 114 · see citing works

Emerging roles of long noncoding RNAs in chemoresistance of pancreatic cancer

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LncRNA MEG3 functions as a ceRNA in regulating hepatic lipogenesis by competitively binding to miR-21 with LRP6

Huang, P. F., Huang, F., Liu, H.-Z., Zhang, T., Yang, M., & Sun, C. (2019) · Metabolism · doi:10.1016/j.metabol.2019.01.018 · Cited by 94 · see citing works

LncRNA SNHG5 regulates imatinib resistance in chronic myeloid leukemia via acting as a CeRNA against MiR-205-5p.

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LncRNA MEG3 influences the proliferation and apoptosis of psoriasis epidermal cells by targeting miR-21/caspase-8

Jia, H., Zhang, K., Lü, W., Xu, G.-W., Zhang, J.-F., & Tang, Z. (2019) · BMC Molecular and Cell Biology · doi:10.1186/s12860-019-0229-9 · Cited by 83 · see citing works

A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers

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MALAT1-miR-101-SOX9 feedback loop modulates the chemo-resistance of lung cancer cell to DDP via Wnt signaling pathway

Chen, W., Zhao, W., Zhang, L., Wang, L., Wang, J., Wan, Z., Hong, Y., & Yu, L. (2017) · Oncotarget · doi:10.18632/oncotarget.21693 · Cited by 78 · see citing works

Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability

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Overexpression of MEG3 sensitizes colorectal cancer cells to oxaliplatin through regulation of miR-141/PDCD4 axis

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Long non-coding RNAs in hematological malignancies: translating basic techniques into diagnostic and therapeutic strategies

Wong, N. K., Huang, C., Islam, R., & Yip, S. P. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0673-6 · Cited by 68 · see citing works

Aberrant LncRNA Expression in Leukemia

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LncRNA MEG3 contributes to drug resistance in acute myeloid leukemia by positively regulating ALG9 through sponging miR‐155

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Long noncoding RNA MEG3 inhibits proliferation of chronic myeloid leukemia cells by sponging microRNA21

Li, Z., Yang, L., Liu, X., Nie, Z.-Y., & Luo, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.047 · Cited by 62 · see citing works

lncRNA MNX1-AS1 Promotes Glioblastoma Progression Through Inhibition of miR-4443

Gao, Y., Xu, Y., Wang, J., Yang, X., Wen, L., & Feng, J. (2018) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504018x15228909735079 · Cited by 60 · see citing works

MEG3 Suppresses Human Pancreatic Neuroendocrine Tumor Cells Growth and Metastasis by Down-Regulation of Mir-183

Zhang, Y., & Feng, H. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484906 · Cited by 56 · see citing works

lncRNA FAM83H‑AS1 is associated with the prognosis of colorectal carcinoma and promotes cell proliferation by targeting the Notch signaling pathway

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BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells

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Interaction of long noncoding RNA MEG3 with miRNAs: A reciprocal regulation

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The Biological Roles and Molecular Mechanisms of Long Non-Coding RNA MEG3 in the Hallmarks of Cancer

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MicroRNA21 and the various types of myeloid leukemia

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MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors

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lncRNA MEG3 Suppresses the Tumorigenesis of Hemangioma by Sponging miR-494 and Regulating PTEN/ PI3K/AKT Pathway

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microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review

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Diagnostic and Therapeutic Implications of Long Non-Coding RNAs in Leukemia

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lncRNAs : New players of cancer drug resistance via targeting ABC transporters

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Expression of non-coding RNAs in hematological malignancies

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Long non-coding RNAs: The novel diagnostic biomarkers for leukemia

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The role of microRNAs in the development, progression and drug resistance of chronic myeloid leukemia and their potential clinical significance

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lncRNA SNHG15 Promotes Ovarian Cancer Progression through Regulated CDK6 via Sponging miR‐370‐3p

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The SOX2OT/miR‑194‑5p axis regulates cell proliferation and mobility of gastric cancer through suppressing epithelial‑mesenchymal transition

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Non-Coding RNAs Are Implicit in Chronic Myeloid Leukemia Therapy Resistance

Rudich, A., Garzon, R., & Dorrance, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012271 · Cited by 21 · see citing works

The role of long non‐coding RNAs and downstream signaling pathways in leukemia progression

Liu, Y., Sun, P., Zhao, Y., & Liu, B. (2020) · Hematological Oncology · doi:10.1002/hon.2776 · Cited by 18 · see citing works

Emerging tumor hypoxia-relieving nanotherapeutics for boosting photodynamic therapy

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LncRNA RP11-395G23.3 suppresses the endometrial cancer progression via regulating microRNA-205-5p/PTEN axis.

Xin, W., Gao, X., Zhao, S., Zhao, P., Yu, H., Wu, Q., & Hua, K. (2020) · PubMed Central · Cited by 17 · see citing works

LncRNA MEG3 suppresses erastin-induced ferroptosis of chondrocytes via regulating miR-885-5p/SLC7A11 axis

Zhu, C., Chen, B., He, X., Li, W., Wang, S., Zhu, X., Li, Y., Wan, P., & Li, X. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09095-9 · Cited by 16 · see citing works

Progress of long noncoding RNAs in anti-tumor resistance

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Long non-coding RNA MEG3 regulates the progress of osteoarthritis by regulating the miR-34a/Klotho axis

Xiong, G., Wang, S., Pan, Z., Liu, N., Zhao, D., Zha, Z., & Ning, R. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-894 · Cited by 16 · see citing works

Current Views on the Interplay between Tyrosine Kinases and Phosphatases in Chronic Myeloid Leukemia

Boni, C., & Sorio, C. (2021) · Cancers · doi:10.3390/cancers13102311 · Cited by 15 · see citing works

Long Noncoding RNAs That Function in Nutrition: Lnc-ing Nutritional Cues to Metabolic Pathways

Lovell, C. D., & Anguera, M. C. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-030244 · Cited by 15 · see citing works

A novel imatinib-upregulated long noncoding RNA plays a critical role in inhibition of tumor growth induced by Abl oncogenes

Ma, Y., Guo, G., Li, T., Wen, F., Yang, J., Chen, B., Wang, X., & Chen, J. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01478-5 · Cited by 14 · see citing works

Long Noncoding RNA Maternally Expressed Gene 3 Is Downregulated, and Its Insufficiency Correlates With Poor-Risk Stratification, Worse Treatment Response, as Well as Unfavorable Survival Data in Patients With Acute Myeloid Leukemia

He, C., Wang, X., Luo, J., Ma, Y., & YANG, Z. K. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820945815 · Cited by 14 · see citing works

Long non‐coding RNAs regulate treatment outcome in leukemia: What have we learnt recently?

Shi, H., Gao, L., Zhang, W., & Jiang, M. (2023) · Cancer Medicine · doi:10.1002/cam4.6027 · Cited by 11 · see citing works

Non-coding RNAs regulating programmed cell death and its implications in cancer chemotherapy resistance

Chen, M., Zhao, P., Chou, J., Zhou, L., Feng, Z., Hao, X., Song, H., & Yang, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144888 · Cited by 11 · see citing works

miRNome profiling of LSC-enriched CD34+CD38−CD26+ fraction in Ph+ CML-CP samples from Argentinean patients: a potential new pharmacogenomic tool

Ruiz, M. S., Sánchez, M. B., Bonecker, S. T., Furtado, C., Koile, D., Yankilevich, P., Cranco, S., Custidiano, M. D. R., Freitas, J., Moiraghi, B., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.612573 · Cited by 12 · see citing works

LncRNA CCAT2 expression at diagnosis predicts imatinib response in chronic phase chronic myeloid leukemia patients

Shehata, A. M. F., Gohar, S. F., Muharram, N. M. M., & Eldin, S. M. K. (2022) · Leukemia Research · doi:10.1016/j.leukres.2022.106838 · Cited by 11 · see citing works

Non-coding RNAs in leukemia drug resistance: new perspectives on molecular mechanisms and signaling pathways

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Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding

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Silencing MEG3 protects PC12 cells from hypoxic injury by targeting miR-21

Deng, D., & Liang, H. (2020) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2020.1725533 · Cited by 10 · see citing works

Basic Knowledge on Bcr-Abl1-Positive Extracellular Vesicles

Jurj, A. M., Paşca, S., Teodorescu, P., Tomuleasa, C., & Berindan‐Neagoe, I. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2019-0510 · Cited by 9 · see citing works

The Tyrosine Kinase-Driven Networks of Novel Long Non-coding RNAs and Their Molecular Targets in Myeloproliferative Neoplasms

Wong, N. K., Luo, S., Chow, E. Y. D., Meng, F., Adesanya, A., Sun, J., Herman, M. H., Jin, W., Li, W., Yip, S. P., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.643043 · Cited by 8 · see citing works

LncRNA MEG3 promotes osteogenesis of hBMSCs by regulating miR-21-5p / SOD3 axis

Wang, S., Xiong, G., Ning, R., Pan, Z., Xu, M., Zha, Z., & Liu, N. (2022) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5661 · Cited by 8 · see citing works

Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats

Qian, K., Zhan, Y., Qiu, X.-L., Wang, X.-Z., & Zhao, N. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.301022 · Cited by 7 · see citing works

Prognostic significance of long non coding maternally expressed gene 3 in pediatric acute myeloid leukemia

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