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Cited by 258Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsFibromyalgia and Chronic Fatigue Syndrome Research

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Familial Association in Adults With Functional Gastrointestinal Disorders

Locke, G. Richard, Zinsmeister, Alan R., Talley, Nicholas J., Fett, Sara L., Melton, L. Joseph·2000·Mayo Clinic Proceedings
DOI 10.4065/75.9.907
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Abstract

Objective To evaluate the association between functional gastrointestinal (GI) symptoms and a family history of abdominal pain or bowel problems. Subjects and methods A valid self-report questionnaire that records GI symptoms and spouse's and first-degree relatives' history of abdominal pain or bowel troubles and includes the psychosomatic symptom checklist (a measure of somatization) was mailed to an age- and sex-stratified random sample of Olmsted County, Minnesota, residents aged 30 to 64 years. A logistic regression model that adjusted for age, sex, and somatic symptom score was used to estimate the odds ratio (OR) and 95% confidence interval (CI) of a positive family history for each functional GI disorder. Results Six hundred forty-three (72%) of 892 eligible subjects returned the survey. Reporting a first-degree relative with abdominal pain or bowel problems was significantly associated with reporting of irritable bowel syndrome (OR, 2.3; 95% CI, 1.3-3.9) and dyspepsia (OR, 1.8; 95% CI, 1.05-3.0) but not constipation, diarrhea, or gastroesophageal reflux. The reporting of a spouse with abdominal pain or bowel problems was not associated with any of these disorders. Conclusions A history of abdominal pain or bowel troubles in first-degree relatives was significantly associated with irritable bowel syndrome and dyspepsia. Whether the familial associations represent similar exposures in a shared environment, heightened familial awareness of GI symptoms (reporting bias), o…

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Research works printed but not linked: 22

  1. Locke, 1996, The epidemiology of functional gastrointestinal disorders in North America, Gastroenterol Clin North Am, 25, 1, 10.1016/S0889-8553(05)70362-9 · DOI
  2. Kay, 1994, The epidemiology of irritable bowel syndrome in a random population: prevalence, incidence, natural history and risk factors, J Intern Med, 236, 23, 10.1111/j.1365-2796.1994.tb01115.x · DOI
  3. Agreus, 1994, The epidemiology of abdominal symptoms: prevalence and demographic characteristics in a Swedish adult population: a report from the Abdominal Symptom Study, Stand J Gastroenterol, 29, 102, 10.3109/00365529409090447 · DOI
  4. Kurland, 1981, The patient record in epidemiology, Sci Am, 245, 54, 10.1038/scientificamerican1081-54 · DOI
  5. Talley, 1992, Dyspepsia and dyspepsia subgroups: a population-based study, Gastroenterology, 102, 1259, 10.1016/0016-5085(92)90764-P · DOI
  6. Talley, 1992, Onset and disappearance of gastrointestinal symptoms and functional gastrointestinal disorders, Am J Epidemiol, 136, 165, 10.1093/oxfordjournals.aje.a116483 · DOI
  7. Talley, 1993, Functional constipation and outlet delay: a population-based study, Gastroenterology, 105, 781, 10.1016/0016-5085(93)90896-K · DOI
  8. Talley, 1994, Gastrointestinal tract symptoms and self-reported abuse: a population based study, Gastroenterology, 107, 1040, 10.1016/0016-5085(94)90228-3 · DOI
  9. Locke, 1997, Prevalence and clinical spectrum of gastroesophagcal reflux: a population-based study in Olmsted County, Minnesota, Gastroenterology, 112, 1448, 10.1016/S0016-5085(97)70025-8 · DOI
  10. Talley, 1989, A patient questionnaire to identify bowel disease, Ann Intern Med, 111, 671, 10.7326/0003-4819-111-8-671 · DOI
  11. Attanasio, 1984, Psychometric properties of the SUNYA revision of die Psychosomatic Symptom Checklist, I Behav Med, 7, 247, 10.1007/BF00845390 · DOI
  12. Locke, 2000, Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities, Am J Gastroenterol, 95, 157, 10.1111/j.1572-0241.2000.01678.x · DOI
  13. Thompson, 1989, Irritable bowel syndrome: guidelines for the diagnosis, Gastroenterol Int, 2, 92
  14. Sullivan, 1995, Irritable bowel syndrome and family history of psychiatric disorder: a preliminary study, Gen Hasp Psychiatry, 17, 43, 10.1016/0163-8343(94)00064-K · DOI
  15. Talley, 1995, Self-reported abuse and gastrointestinal disease in outpatients: association with irritable bowel-type symptoms, Am J Gastroenterol, 90, 366
  16. Drossman, 1996, Health status by gastrointestinal diagnosis and abuse history, Gastroenterology, 110, 999, 10.1053/gast.1996.v110.pm8613034 · DOI
  17. Levy, 1997, Intergenerational transmission of GI illness behavior [abstract], Gastroenterology, 112, A775
  18. Morris-Yates, 1998, Evidence of a genetic contribution to functional bowel disorder, Am J Gastroenterol, 93, 1311, 10.1111/j.1572-0241.1998.440_j.x · DOI
  19. Locke, 1999, Risk factors associated with symptoms of gastroesophageal reflux, Am I Med, 106, 642, 10.1016/S0002-9343(99)00121-7 · DOI
  20. Romero, 1997, Familial aggregation of gastroesophageal reflux in patients with Barrett's esophagus and esophageal adenocardnoma, Gastroenterology, 113, 1449, 10.1053/gast.1997.v113.pm9352846 · DOI
  21. Trudgill, 1999, Familial clustering of reflux symptoms, Am J Gastroenterol, 94, 1172, 10.1111/j.1572-0241.1999.01060.x · DOI
  22. Agreus, 1995, Irritable bowel syndrome and dyspepsia m the general population: overlap and lack of stability over time, Gastroenterology, 109, 671, 10.1016/0016-5085(95)90373-9 · DOI · Paper page

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Metadata

Authors
Locke, G. R., Zinsmeister, A. R., Talley, N. J., Fett, S. L., & Melton, L. J.
Affiliations
  • Mayo Clinic (US)
  • The University of Sydney (AU)
Corresponding author
Locke, G. Richard
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
2000-09
Volume
75
Issue
9
Pages
907-912
ISSN
0025-6196 (ISSN-L)
DOI
10.4065/75.9.907
OpenAlex
W1999734650
Cited by
258
References
0
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 19 · 2014: 12 · 2013: 8 · 2012: 16
FWCI
4.61
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mayo Clinic Proceedings (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG 09440)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords
functional gastrointestinal disorders, familial association, irritable bowel syndrome, dyspepsia, abdominal pain, bowel problems, family history (medicine), first-degree relatives, somatization, psychosomatic symptoms, genetic susceptibility, shared environment, reporting bias
MeSH terms
Adult, Colonic Diseases, Functional, Dyspepsia, Female, Humans, Male, Medical Record Linkage, Middle Aged, Minnesota, Pedigree, Population Surveillance, Surveys and Questionnaires, Risk Factors, Sampling Studies, Bias, Logistic Models, Odds Ratio, Databases, Factual

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