Cited by 86Cardiac Fibrosis and RemodelingCardiovascular Function and Risk FactorsCardiomyopathy and Myosin Studies

A Look Between the Cardiomyocytes: The Extracellular Matrix in Heart Failure

Miner, Edward C., Miller, Wayne L.·2006·Mayo Clinic Proceedings

Abstract

The extracellular matrix (ECM) of the heart dynamically interacts with various cellular components of the myocardium, including the myocytes and connective tissue cells. With the development and progression of heart failure, left ventricular (LV) myocardial remodeling occurs. The progression of LV remodeling is accompanied by alterations in the structure and function of the ECM that occur after injury resulting from neurohormonal activation, changes in LV loading conditions, and alterations in myocardial perfusion and metabolism and is secondary to a host of nonmyocyte signaling pathways that affect repair and remodeling of the myocardium as a whole. This article attempts to review some of these processes and their interactions and to provide a focus to the often overlooked contribution of the ECM to the development and progression of heart failure and thereby its potential role as a target for therapy for heart failure.

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Registry

Crossref · 10.4065/81.1.71

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71 of 71 references verified0 citation errors · 0 not checkable

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  • Alterations in the composition and structure of the extracellular matrix can make an important contribution to changes in cardiac size, structure, and function in heart failure.

    “Alterations in the composition and structure of the extracellular matrix (ECM) can make an important contribution to changes in the cardiac size, structure, and function in heart failure (98, 237).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [237]

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Authors
Miner, E. C., & Miller, W. L.
Affiliations
Mayo Clinic (US)
Corresponding author
Miller, Wayne L.
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
2006-01
Volume
81
Issue
1
Pages
71-76
ISSN
0025-6196 (ISSN-L)
OpenAlex
W2066561195
Cited by
86
References
72
Citations by year
2026: 4 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 8
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Locations
  • Mayo Clinic Proceedings (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords
extracellular matrix, heart failure, left ventricular remodeling, cardiomyocytes, cardiac remodeling, neurohormonal activation, myocardial injury, myocardial repair
MeSH terms
Animals, Extracellular Matrix, Heart Failure, Humans, Renin-Angiotensin System, Disease Progression, Ventricular Remodeling, Myocytes, Cardiac

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