A Look Between the Cardiomyocytes: The Extracellular Matrix in Heart Failure
Abstract
The extracellular matrix (ECM) of the heart dynamically interacts with various cellular components of the myocardium, including the myocytes and connective tissue cells. With the development and progression of heart failure, left ventricular (LV) myocardial remodeling occurs. The progression of LV remodeling is accompanied by alterations in the structure and function of the ECM that occur after injury resulting from neurohormonal activation, changes in LV loading conditions, and alterations in myocardial perfusion and metabolism and is secondary to a host of nonmyocyte signaling pathways that affect repair and remodeling of the myocardium as a whole. This article attempts to review some of these processes and their interactions and to provide a focus to the often overlooked contribution of the ECM to the development and progression of heart failure and thereby its potential role as a target for therapy for heart failure.
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Alterations in the composition and structure of the extracellular matrix can make an important contribution to changes in cardiac size, structure, and function in heart failure.
“Alterations in the composition and structure of the extracellular matrix (ECM) can make an important contribution to changes in the cardiac size, structure, and function in heart failure (98, 237).”
From Cardiac remodeling in obesity (2008) · cites this paper as [237]
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- Authors
- Miner, E. C., & Miller, W. L.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Miller, Wayne L.
- ORCID
- Miller, Wayne L.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 81
- Issue
- 1
- Pages
- 71-76
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W2066561195
- Cited by
- 86
- References
- 72
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 8 · 2012: 8
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- extracellular matrix, heart failure, left ventricular remodeling, cardiomyocytes, cardiac remodeling, neurohormonal activation, myocardial injury, myocardial repair
- MeSH terms
- Animals, Extracellular Matrix, Heart Failure, Humans, Renin-Angiotensin System, Disease Progression, Ventricular Remodeling, Myocytes, Cardiac
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