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Cited by 878

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

General Principles of Antimicrobial Therapy

Open access
Leekha, Surbhi, Terrell, Christine L., Edson, Randall S.·2011·Mayo Clinic Proceedings

Abstract

Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important considerations when prescribing antimicrobial therapy include obtaining an accurate diagnosis of infection; understanding the difference between empiric and definitive therapy; identifying opportunities to switch to narrow-spectrum, cost-effective oral agents for the shortest duration necessary; understanding drug characteristics that are peculiar to antimicrobial agents (such as pharmacodynamics and efficacy at the site of infection); accounting for host characteristics that influence antimicrobial activity; and in turn, recognizing the adverse effects of antimicrobial agents on the host. It is also important to understand the importance of antimicrobial stewardship, to know when to consult infectious disease specialists for guidance, and to be able to identify situations when antimicrobial therapy is not needed. By following these general principles, all practicing physicians should be able to use antimicrobial agents in a responsible manner that benefits both the individual patient and the community.

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Metadata

Authors
Leekha, S., Terrell, C. L., & Edson, R. S.
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
2011-02
Volume
86
Issue
2
Pages
156-167
ISSN
0025-6196 (ISSN-L)
OpenAlex
W1998378687
Cited by
878
References
5
FWCI
19.57
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: General Principles of Antimicrobial Therapy. https://app.cochat.ai/papers/10.4065/mcp.2010.0639
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Leekha, S., Terrell, C. L., & Edson, R. S. (2011). General Principles of Antimicrobial Therapy. Mayo Clinic Proceedings. https://doi.org/10.4065/mcp.2010.0639

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.