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Cited by 367

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains

Open access
Miklasińska-Majdanik, Maria, Kępa, Małgorzata, Wojtyczka, Robert D., Idzik, Danuta, Wąsik, Tomasz J.·2018·International Journal of Environmental Research and Public Health
DOI 10.3390/ijerph15102321
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Abstract

There is a growing body of evidence that flavonoids show antibacterial activity against both Gram-positive and Gram-negative bacteria. The mechanisms of action of phenolic compounds on bacterial cell have been partially attributed to damage to the bacterial membrane, inhibition of virulence factors such as enzymes and toxins, and suppression of bacterial biofilm formation. What is more, some natural polyphenols, aside from direct antibacterial activity, exert a synergistic effect when combined with common chemotherapeutics. Many studies have proved that in synergy with antibiotics plant flavonoids pose a promising alternative for therapeutic strategies against drug resistant bacteria. In this review most recent reports on antimicrobial action of polyphenols on Staphylococcus aureus strains are described, highlighting where proven, the mechanisms of action and the structure–activity relationships. Since many reports in this field are, to some extent, conflicting, a unified in vitro and in vivo susceptibility testing algorithms should be introduced to ensure the selection of effective antibacterial polyphenolic compounds with low cytotoxicity and minimal side effects.

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Crossref · 10.3390/ijerph15102321

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Metadata

Authors
Miklasińska-Majdanik, M., Kępa, M., Wojtyczka, R. D., Idzik, D., & Wąsik, T. J.
Venue
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Published
2018-10-22
Volume
15
Issue
10
Pages
2321
ISSN
1660-4601 (ISSN-L)
DOI
10.3390/ijerph15102321
OpenAlex
W2896187181
Cited by
367
References
66
FWCI
16.82
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains. https://app.cochat.ai/papers/10.3390/ijerph15102321
The paper
Miklasińska-Majdanik, M., Kępa, M., Wojtyczka, R. D., Idzik, D., & Wąsik, T. J. (2018). Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph15102321

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.