Choline acetyltransferase-containing neurons in the human parietal neocortex
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A number of immunocytochemical studies have indicated the presence of cholinergic neurons in the cerebral cortex of various species of mammals. Whether such cholinergic neurons in the human cerebral cortex are exclusively of subcortical origin is still debated. In this immunocytochemical study, the existence of cortical cholinergic neurons was investigated on surgical samples of human parietal association neocortex using a highly specific monoclonal antibody against choline acetyltransferase (ChAT), the acetylcholine biosynthesising enzyme. ChAT immunoreactivity was detected in a subpopulation of neurons located in layers II and III. These were small or medium-sized pyramidal neurons which showed cytoplasmic immunoreactivity in the perikarya and processes, often in close association to blood microvessels. This study, providing demonstration of ChAT neurons in the human parietal neocortex, strongly supports the existence of intrinsic cholinergic innervation of the human neocortex. It is likely that these neurons contribute to the cholinergic innervation of the intracortical microvessels.
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There is some indication from anatomical studies that cholinergic interneurons are present in the rodent and human neocortex, but not the non-human primate cortex.
“there is some indication from anatomical studies that cholinergic interneurons are present in the rodent and human neocortex, but not the non-human primate cortex (Benagiano et al., 2003; Mesulam, 1995; von Engelhardt et al., 2007).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Benagiano et al., 2003
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References 17 · Cited by 13
Research works printed but not linked: 2
- Hendry SHC, Jones EG, Killackey HP, Chalupa LM. Choline acetyl- transferase-immunoreactive neurons in fetal monkey cerebral cor- tex. Dev Brain Res 1987;37:313-7.
- Suzuki N, Hardebo JE. The cerebrovascular parasympathetic innerva- tion. Cerebrovasc. Brain Metabol Rev 1993;5:33-46.
- Authors
- Benagiano, V, Virgintino, D., Flace, P., Girolamo, F., Errede, M., & Roncali, L.
- Affiliations
- Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari (IT)
- University of Foggia (IT)
- Venue
- European Journal of Histochemistry
- Publisher
- PAGEPress Publications
- Published
- 2009-06-26
- Volume
- 47
- Issue
- 3
- Pages
- 253
- ISSN
- 1121-760X (ISSN-L)
- 2038-8306
- DOI
- 10.4081/835
- OpenAlex
- W1996192469
- Cited by
- 13
- References
- 17
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 2 · 2020: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- European Journal of Histochemistry (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- choline acetyltransferase, cortical cholinergic neurons, parietal association cortex, human cerebral cortex, cholinergic innervation, pyramidal neurons, blood vessel innervation, acetylcholine synthesis
- MeSH terms
- Aged, Antibodies, Monoclonal, Choline O-Acetyltransferase, Humans, Middle Aged, Neurons, Neocortex
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