Dopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons
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Dopamine D1 and D2 receptor immunohistochemistry and Golgi techniques were used to study the structure of the adult rat arcuate-median eminence complex, and determine the distribution of the dopamine D1 and D2 receptor immunoreactivities therein, particularly in relation to the tubero-infundibular dopamine neurons. Punctate dopamine D1 and D2 receptor immunoreactivities, likely located on nerve terminals, were enriched in the lateral palisade zone built up of nerve terminals, while the densities were low to modest in the medial palisade zone. A codistribution of dopamine D1 receptor or dopamine D2 receptor immunoreactive puncta with tyrosine hydroxylase immunoreactive nerve terminals was demonstrated in the external layer. Dopamine D1 receptor but not dopamine D2 receptor immnunoreactivites nerve cell bodies were found in the ventromedial part of the arcuate nucleus and in the lateral part of the internal layer of the median eminence forming a continuous cell mass presumably representing neuropeptide Y immunoreactive nerve cell bodies. The major arcuate dopamine/ tyrosine hydroxylase nerve cell group was found in the dorsomedial part. A large number of tyrosine hydroxylase immunoreactive nerve cell bodies in this region demonstrated punctate dopamine D1 receptor immunoreactivity but only a few presented dopamine D2 receptor immunoreactivity which were mainly found in a substantial number of tyrosine hydroxylase cell bodies of the ventral periventricular hypothalamic nucleus, also belonging to the tubero-infundibular dopamine neurons. Structural evidence for projections of the arcuate nerve cells into the median eminence was also obtained. Distal axons formed horizontal axons in the internal layer issuing a variable number of collaterals classified into single or multiple strands located in the external layer increasing our understanding of the dopamine nerve terminal networks in this region. Dopamine D1 and D2 receptors may therefore directly and differentially modulate the activity and /or Dopamine synthesis of substantial numbers of tubero-infundibular dopamine neurons at the somatic and terminal level. The immunohistochemical work also gives support to the view that dopamine D1 receptors and/or dopamine D2 receptors in the lateral palisade zone by mediating dopamine volume transmission may contribute to the inhibition of luteinizing hormone releasing hormone release from nerve terminals in this region.
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There exists a neuronal D2R positive population in the arcuate nucleus of the hypothalamus that can contribute to the ability of cabergoline to inhibit food intake.
“There also exists a neuronal D2R positive population in the arcuate nucleus of the hypothalamus (Romero-Fernandez et al., 2014) that can contribute to the ability of the ergot D2R agonist cabergoline to inhibit food intake (Kern et al., 2015).”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Romero-Fernandez et al., 2014
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Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System
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- Authors
- Romero-Fernandez, W., Borroto-Escuela, D. O., Vargas-Barroso, V., Narváez, M., Di Palma, M., Agnati, L. F., Larriva Sahd, J., & Fuxe, K.
- Affiliations
- Universidad de Málaga (ES)
- Karolinska Institutet (SE)
- ORCID
- Narváez, M.
- Venue
- European Journal of Histochemistry
- Publisher
- PAGEPress Publications
- Published
- 2014-07-18
- Volume
- 58
- Issue
- 3
- Pages
- 2400-2400
- ISSN
- 1121-760X (ISSN-L)
- 2038-8306
- PMC
- PMC4194391
- OpenAlex
- W2012953622
- Cited by
- 27
- References
- 30
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 3 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- European Journal of Histochemistry (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Funders
- Vetenskapsrådet (04X-715)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- dopamine D1 receptor, dopamine D2 receptor, arcuate nucleus, median eminence, tyrosine hydroxylase, neuropeptide Y, gonadotropin-releasing hormone, dopamine nerve terminals, axonal projections, rats
- MeSH terms
- Animals, Arcuate Nucleus of Hypothalamus, Fluorescent Antibody Technique, Male, Neurons, Rats, Sprague-Dawley, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats
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