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Magnetic resonance imaging based muscle strain rate mapping during eccentric contraction to study effects of unloading induced by unilateral limb suspension
Open accessAbstract
Age- and disuse- related loss of muscle force is disproportionately larger than the loss of muscle mass. Earlier studies reported that comparing concentric and eccentric contractions, there is a significant age-related decrease in force only in concentric contractions. Magnetic Resonance Imaging enables mapping of muscle deformation and has been used to study isometric but not eccentric contractions. We report MRI based strain rate mapping of the medial gastrocnemius in subjects pre- and post-unloading induced by Unilateral Limb Suspension. In contrast to isometric contraction, no difference in strain rate indices were observed post-unloading, in conformance with preserved force during eccentric contractions.
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Changes in the extracellular matrix with unloading may contribute to the nonuniform force loss.
“Additionally, as the extracellular matrix contributes to lateral force transmission (via costameres that enable nonmyofascial force transmission), changes in the extracellular matrix with unloading may contribute to the nonuniform force loss (89–91).”
From Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review (2021) · cites this paper as [90]
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Research works printed but not linked: 13
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- Roig M, MacIntyre DL, Eng JJ, Reid WD. Preservation of eccentric strength in older adults: Evidence, mechanisms and implications for training and rehabilitation. Exp Gerontol. 2010 Jun;45(6):400–9. · DOI
- Malis V, Sinha U, Csapo R, et al. Relationship of changes in strain rate indices estimated from velocity-encoded MR imaging to loss of muscle force following disuse atrophy. Magn Reson Med. 2018;79:912–22. · DOI
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Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review
Marusic, U., Narici, M., Simunic, B., Pisot, R., & Ritzmann, R. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00363.2020 · Cited by 185
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Metadata
- Authors
- Sinha, U., Malis, V., Csapo, R., Narici, M., & Sinha, S.
- Affiliations
- San Diego State University (US)
- University of California San Diego (US)
- UMIT TIROL - Private University for Health Sciences and Health Technology (AT)
- University of Padua (IT)
- Corresponding author
- Sinha, Usha
- Malis, Vadim
- Csapo, Robert
- Narici, Marco
- Sinha, Shantanu
- Venue
- European Journal of Translational Myology
- Publisher
- PAGEPress Publications
- Published
- 2020-04-01
- Volume
- 30
- Issue
- 1
- Pages
- 139-143
- ISSN
- 2037-7452 (ISSN-L)
- 2037-7460
- PMC
- PMC7254429
- OpenAlex
- W3013661477
- Cited by
- 8
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2021: 3 · 2020: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- European Journal of Translational Myology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (R01AG056999)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- eccentric contraction, muscle unloading, medial gastrocnemius, muscle force, disuse atrophy, age-related muscle loss, muscle deformation
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