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Cited by 169Bacterial Identification and Susceptibility TestingAntibiotic Use and ResistanceInfections and bacterial resistance

Advances in Rapid Identification and Susceptibility Testing of Bacteria in the Clinical Microbiology Laboratory: Implications for Patient Care and Antimicrobial Stewardship Programs

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Maurer, Florian P., Christner, Martin, Hentschke, Moritz, Rohde, Holger·2017·Infectious Disease Reports
DOI 10.4081/idr.2017.6839PMC PMC5391540
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Abstract

Early availability of information on bacterial pathogens and their antimicrobial susceptibility is of key importance for the management of infectious diseases patients. Currently, using traditional approaches, it usually takes at least 48 hours for identification and susceptibility testing of bacterial pathogens. Therefore, the slowness of diagnostic procedures drives prolongation of empiric, potentially inappropriate, antibacterial therapies. Over the last couple of years, the improvement of available techniques (e.g. for susceptibility testing, DNA amplification assays), and introduction of novel technologies (e.g. MALDI-TOF) has fundamentally changed approaches towards pathogen identification and characterization. Importantly, these techniques offer increased diagnostic resolution while at the same time shorten the time-to-result, and are thus of obvious importance for antimicrobial stewardship. In this review, we will discuss recent advances in medical microbiology with special emphasis on the impact of novel techniques on antimicrobial stewardship programs.

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  • A rapid introduction of an adequate antimicrobial treatment is essential for optimal care, reducing mortality and length of hospital stay, and to fight antibiotic resistance.

    “A rapid introduction of an adequate antimicrobial treatment is essential for optimal care, reducing mortality and length of hospital stay, and to fight antibiotic resistance [1].”

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Authors
Maurer, F. P., Christner, M., Hentschke, M., & Rohde, H.
Affiliations
  • University Medical Center Hamburg-Eppendorf (DE)
  • Institute of Medical Microbiology and Hygiene (DE)
  • Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer (DE)
Corresponding author
Rohde, Holger
ORCID
Venue
Infectious Disease Reports
Publisher
MDPI AG
Published
2017-03-30
Volume
9
Issue
1
Pages
6839
ISSN
  • 2036-7430 (ISSN-L)
  • 2036-7449
DOI
10.4081/idr.2017.6839
PMC
PMC5391540
OpenAlex
W2601990403
Cited by
169
References
2
Citations by year
2026: 14 · 2025: 17 · 2024: 20 · 2023: 23 · 2022: 13 · 2021: 23 · 2020: 18 · 2019: 13 · 2018: 21 · 2017: 7
FWCI
2.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Infectious Disease Reports (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Infections and bacterial resistance
Keywords
bacterial pathogen identification, antimicrobial susceptibility testing, MALDI-TOF mass spectrometry, rapid diagnostics, antimicrobial stewardship, empirical antibiotic therapy, time to result, clinical microbiology laboratory

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