Electroconvulsive Therapy for Bipolar Disorder: Evidence Supporting What Clinicians Have Long Known: (Commentary)
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Article Abstract Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text. The effectiveness of electroconvulsive therapy (ECT) as an acute antidepressant is well known; less commonly known is the effectiveness of ECT as a mood stabilizer, that is, as an antimanic treatment, and by extension, an antimixed state treatment. In this issue of the Journal, Medda and colleagues†report of the high effectiveness of ECT in a cohort of nearly 200 bipolar patients with mixed affective states adds important evidence to this knowledge base. In this commentary, we review the evidence for the effectiveness of ECT in all phases of bipolar disorder. There is no reason to suspect that ECT would be any less effective for bipolar depression than for unipolar depression, yet this remains a commonly held belief.
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Electroconvulsive therapy is an effective treatment for bipolar disorder.
“Electroconvulsive therapy (ECT) is an effective treatment for bipolar disorder.7”
From Magnetic seizure therapy is efficacious and well tolerated for treatment-resistant bipolar depression: An open-label clinical trial (2020) · cites this paper as [7]
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Cites
Electroconvulsive therapy of acute manic episodes: a review of 50 years' experience
Mukherjee, S., Sackeïm, H. A., & Schnur, D. B. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.2.169 · Cited by 395 · see citing works
ECT in bipolar and unipolar depression: differences in speed of response
Daly, J. J., Prudic, J., Devanand, D. P., Nobler, M. S., Lisanby, S. H., Peyser, S., Roose, S. P., & Sackeïm, H. A. (2001) · Bipolar Disorders · doi:10.1034/j.1399-5618.2001.030208.x · Cited by 191 · see citing works
Electroconvulsive therapy is equally effective in unipolar and bipolar depression
Bailine, S. H., Fink, M., Knapp, R. G., Petrides, G., Husain, M. M., Rasmussen, K. G., Sampson, S. M., Mueller, M., McClintock, S. M., Tobias, K. G., et al. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01493.x · Cited by 107 · see citing works
Self-citationCiapparelli, A., Dell’Osso, L., Tundo, A., Pini, S., Chiavacci, M. C., Sacco, I. D., & Cassano, G. B. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n07a09 · Cited by 107 · see citing works
Ultra‐brief pulse ECT in bipolar and unipolar depressive disorder: differences in speed of response
Sienaert, P., Vansteelandt, K., Demyttenaere, K., & Peuskens, J. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00702.x · Cited by 98 · see citing works
The Efficacy of ECT in Mixed Affective States
Devanand, D. P., Polanco, P., Cruz, R., Shah, S. A., Paykina, N., Singh, K., & Majors, L. F. (2000) · Journal of Ect · doi:10.1097/00124509-200003000-00004 · Cited by 91 · see citing works
ECT in Mixed Affective States: A Case Series
Gruber, N. P., Dilsaver, S. C., Shoaib, A. M., & Swann, A. C. (2000) · Journal of Ect · doi:10.1097/00124509-200006000-00010 · Cited by 69 · see citing works
Medda, P., Perugi, G., Zanello, S., Ciuffa, M., Rizzato, S., & Cassano, G. B. (2010) · Journal of Ect · doi:10.1097/yct.0b013e3181b00f1e · Cited by 69 · see citing works
Miller, M. C. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.4.aj1524654 · Cited by 12 · see citing works
Efficacy of ECT in bipolar and unipolar depression in a real life hospital setting
Narayanaswamy, J. C., Viswanath, B., Reddy, P. V., Kumar, K. R., Thirthalli, J., & Gangadhar, B. N. (2013) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2013.10.006 · Cited by 11 · see citing works
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Research works printed but not linked: 4
- [1]1. Medda P, Toni C, Marian MG, et al. Electroconvulsive therapy in 197 patients with a severe, drug-resistant bipolar mixed state: treatment outcome and predictors of response. J Clin Psychiatry . 2015;76(9): 1168-1173.
- [3]3. Dierckx B, Heijnen WT, van den Broek WW, et al. Efficacy of electroconvulsive therapy in bipolar versus unipolar major depression: a metaanalysis. Bipolar Disord . 2012;14(2):146-150. doi:10./j39-5618.2097x PubMed
- [7]7. Medda P, Perugi G, Zanello S, et al. Response to ECT in bipolar I, bipolar II and unipolar depression. J Affect Disord . 2009;118(1-3):55-59. doi:10.6/ja2901.4 PubMed
- [9]9. Black DW, Winokur G, Nasrallah A. Treatment of mania: a naturalistic study of electroconvulsive therapy versus lithium in 438 patients. J Clin Psychiatry . 1987;48(4):132-139. PubMed
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Perugi, G., Medda, P., Toni, C., Mariani, M., Socci, C., & Mauri, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666161017233642 · Cited by 167 · see citing works
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Sartorius, A., Demirakça, T., Böhringer, A., von Hohenberg, C. C., Aksay, S. S., Bumb, J. M., Kranaster, L., Nickl‐Jockschat, T., Grözinger, M., Thomann, P. A., et al. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.11.017 · Cited by 58 · see citing works
The Use of ECT in the Elderly—Looking Beyond Depression
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Tang, V. M., Blumberger, D. M., Dimitrova, J., Throop, A., McClintock, S. M., Voineskos, D., Downar, J., Knyahnytska, Y., Mulsant, B. H., Fitzgerald, P. B., et al. (2020) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190098 · Cited by 22 · see citing works
Management of obsessive-compulsive disorder comorbid with bipolar disorder
Kazhungil, F., & Mohandas, E. (2016) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.192001 · Cited by 17 · see citing works
The Role of Electroconvulsive Therapy in the Treatment of Severe Bipolar Mixed State
Perugi, G., Medda, P., Barbuti, M., Novi, M., & Tripodi, B. (2019) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2019.10.010 · Cited by 18 · see citing works
Rask, O., Suneson, K., Holmström, E., Bäckström, B., & Johansson, B. A. (2017) · Journal of Medical Case Reports · doi:10.1186/s13256-017-1508-8 · Cited by 9 · see citing works
Rödström, M. Y., Johansson, B. A., Bäckström, B., Movahed, P., Forslund, C.-M., & Rask, O. (2021) · Case Reports in Psychiatry · doi:10.1155/2021/3371591 · Cited by 6 · see citing works
ECT: Patient Selection and Preparation
Kellner, C. H. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108242028.003
Self-citationElectroconvulsive therapy for acute affective episodes in people with bipolar disorder
Munkholm, K., Jørgensen, K. J., & Paludan‐Müller, A. S. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014996
- Authors
- Kellner, C. H., Ahle, G. M., & Geduldig, E. T.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Kellner, Charles H.
- ORCID
- Kellner, Charles H.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2015-09-23
- Volume
- 76
- Issue
- 09
- Pages
- e1151-e1152
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2118230715
- Cited by
- 12
- References
- 10
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- electroconvulsive therapy, bipolar disorder, mood stabilization, mixed affective states, bipolar depression, treatment efficacy
- MeSH terms
- Bipolar Disorder, Drug Resistance, Electroconvulsive Therapy, Female, Humans, Male
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