Cited by 172Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesHistorical and Modern Theater Studies

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The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder

McIntyre, Roger S., Best, Michael W., Bowie, Christopher R., Carmona, Nicole E., Cha, Danielle S., Lee, Yena, Subramaniapillai, Mehala, Mansur, Rodrigo B., Barry, Harry, Baune, Bernhard T., Culpepper, Larry, Fossati, Philippe, Greer, Tracy L., Harmer, Catherine, Klag, Esther, Lam, Raymond W., Wittchen, Hans-Ulrich, Harrison, John·2017·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.16m11329

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Abstract

OBJECTIVE: To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD). METHODS: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100). Between January and June 2016, subjects completed the THINC-it, which includes variants of the Choice Reaction Time Identification Task (IDN), One-Back Test, Digit Symbol Substitution Test, Trail Making Test-Part B, and the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D). RESULTS: The THINC-it required approximately 10 to 15 minutes for administration and was capable of detecting cognitive deficits in adults with MDD. A total of 44.4% of adults with MDD exhibited cognitive performance at ≥ 1.0 SD below that of healthy controls on standardized mean scores of the THINC-it. Concurrent validity of the overall tool, based on a calculated composite score, was acceptable (r = 0.539, P < .001). Concurrent validity of the component tests ranged from -0.083 (IDN) to 0.929 (PDQ-5-D). Qualitative survey results indicated that there was a high level of satisfaction and perceived value in administering the THINC-it regarding its impact on the appropriateness and quality of care being received. CONCLUSIONS: The THINC-it is a valid and sensitive tool for detecting cognitive dysfunction in adults with MDD that is free, easy to use, and rapidly administered. The THINC-it should be incorporated into the assessment and measurement of all patients with MDD, particularly among those with enduring functional impairment. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02508493.

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“A shorter time represented better corresponding cognitive function (Dalby et al., 2022; McIntyre et al., 2017; Zhu et al., 2024).”
Effects of Adjunctive Exercise Therapy in Patients with Bipolar Depression: A Pilot Multicenter Cluster-Randomized Controlled Trial
Hamada, F., Hori, H., Kumagai, H., Ogata, M., Yokoyama, H., Tomiyama, Y., Sugawara, H., Asada, R., Hatanaka, A., Masuda, M., et al. (2026) · Metabolites · doi:10.3390/metabo16090679
“Cognitive function was assessed using the THINC-it cognitive assessment battery [39], which includes four objective cognitive tasks and one self-report questionnaire.”

Authors: McIntyre, R. S., Best, M. W., Bowie, C. R., Carmona, N. E., Cha, D. S., Lee, Y., Subramaniapillai, M., Mansur, R. B., Barry, H., Baune, B. T., Culpepper, L., Fossati, P., Greer, T. L., Harmer, C., Klag, E., Lam, R. W., Wittchen, H.-U., & Harrison, J.
Affiliations: University Health Network (CA)
Queen's University (CA)
Centre for Addiction and Mental Health (CA)
The University of Adelaide (AU)
Boston University (US)
Centre National de la Recherche Scientifique (FR)
The University of Texas Southwestern Medical Center (US)
Warneford Hospital (GB)
University of British Columbia (CA)
King's College London (GB)
ORCID: McIntyre, Roger S.
Best, Michael W.
Bowie, Christopher R.
Carmona, Nicole E.
Lee, Yena
Subramaniapillai, Mehala
Mansur, Rodrigo B.
Baune, Bernhard T.
Culpepper, Larry
Fossati, Philippe
Greer, Tracy L.
Harmer, Catherine
Lam, Raymond W.
Harrison, John
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2017-08-23
Volume: 78
Issue: 7
Pages: 873-881
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.16m11329
OpenAlex: W2747517649
Cited by: 172
References: 0
Citations by year: 2026: 21 · 2025: 20 · 2024: 17 · 2023: 22 · 2022: 26 · 2021: 16 · 2020: 15 · 2019: 16 · 2018: 15 · 2017: 4
FWCI: 9.54
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords: cognitive impairment, major depressive disorder, screening tool, computerized cognitive assessment, concurrent validity, Trail Making Test, Digit Symbol Substitution Test, functional disability
MeSH terms: Adolescent, Adult, Aged, Cognition Disorders, Major Depressive Disorder, Diagnosis, Computer-Assisted, Female, Humans, Male, Mass Screening, Middle Aged, Neuropsychological Tests, Psychometrics, Recurrence, Reference Values, Reproducibility of Results, Young Adult

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The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder

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