Wrestling With Antidepressant Use in Bipolar Disorder: The Ongoing Debate
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The transition from a diagnosis of MDD to one of bipolar disorder occurs at a rate of approximately 1-3% per year.
“Furthermore, it is reported that the transition from a diagnosis of MDD to one of bipolar disorder occurs at a rate of approximately 1- 3% per year”
From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [159]
The discussion of polarity switches in the ASCP Corner section concerns people already diagnosed with bipolar depression, not a change in diagnosis from MDD to bipolar disorder. Searches for an MDD-to-bipolar diagnostic transition and an annual rate of 1–3% found no passage addressing the claim; page numbers are unavailable in our copy. (LLM, conf=0.76)
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Research works printed but not linked: 2
- Sachs GS, Nierenberg AA, Calabrese JR, et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med. 2007;356(17):1711-1722.
- Altshuler LL, Post RM, Hellemann G, et al. Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study. J Clin Psychiatry. 2009;70(4):450-457.
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McIntyre, R. S., Alsuwaidan, M., Baune, B. T., Berk, M., Demyttenaere, K., Goldberg, J. F., Gorwood, P., Ho, R., Kasper, S., Kennedy, S. H., et al. (2023) · World Psychiatry · doi:10.1002/wps.21120 · Cited by 836 · see citing works
Self-citationAaronson, S. T., van der Vaart, A., Miller, T., LaPratt, J., Swartz, K., Shoultz, A., Lauterbach, M., Sackeim, H. A., & Suppes, T. (2024) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.4685 · Cited by 114 · see citing works
Eye Movement Abnormalities in Major Depressive Disorder
Takahashi, J., Hirano, Y., Miura, K., Morita, K., Fujimoto, M., Yamamori, H., Yasuda, Y., Kudo, N., Shishido, E., Okazaki, K., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.673443 · Cited by 45 · see citing works
Park, J. H., Núñez, N. A., Gardea‐Resendez, M., Gerberi, D., Breitinger, S. A., Veldić, M., Frye, M. A., & Singh, B. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4433 · Cited by 15 · see citing works
Bipolar Disorder: An Update on Neurobiology and Treatment
Soliman, M. A., Khafif, T. C., Sylvia, L. G., & Nierenberg, A. A. (2026) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20260051 · Cited by 2 · see citing works
Self-citationChoi, K. (2022) · Psychiatry Investigation · doi:10.30773/pi.2022.0113 · Cited by 2 · see citing works
Treating chronic insomnia: An alternating medication strategy
Kaplan, M. (2023) · Current Psychiatry · doi:10.12788/cp.0397 · Cited by 1 · see citing works
Sanches, M., & Soares, J. C. (2025) · Cambridge University Press eBooks · doi:10.1017/9781009334730.019
- Authors
- Goldberg, J. F., Nierenberg, A. A., & Iosifescu, D. V.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Harvard University (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Goldberg, Joseph F.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2021-01-19
- Volume
- 82
- Issue
- 1
- ISSN
- 0160-6689 (ISSN-L)
- 1555-2101
- OpenAlex
- W3121457013
- Cited by
- 9
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 2 · 2021: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- bipolar disorder, antidepressant use, antidepressant side effects, bipolar depression, mood stabilizers
- MeSH terms
- Clinical Decision-Making, Antidepressive Agents, Bipolar Disorder, Humans, Practice Guidelines as Topic
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