CoChat
Sign Up
Cited by 156Posttraumatic Stress Disorder ResearchMemory and Neural MechanismsPsychoanalysis and Psychopathology Research

The DOI matches its Crossref record.

Reduced Posterior Hippocampal Volume in Posttraumatic Stress Disorder

Open access
Bonne, Omer, Vythilingam, Meena, Inagaki, Masatoshi, Wood, Suzanne, Neumeister, Alexander, Nugent, Allison C., Snow, Joseph, Luckenbaugh, David A., Bain, Earle E., Drevets, Wayne C., Charney, Dennis S.·2008·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.v69n0707PMC PMC2684983
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure. METHOD: Twenty-two adult outpatients with PTSD (11 after prolonged prepubertal trauma and 11 after single adult trauma) and 22 matched healthy subjects were scanned at the National Institute of Mental Health using high-resolution 3T magnetic resonance imaging between September 2003 and August 2004. PTSD diagnosis was conferred using the Structured Clinical Interview for DSM-IV. Volumes of whole, anterior, and posterior hippocampus and subiculum were compared between groups. RESULTS: Total hippocampal volume was lower in patients with PTSD (p = .02), with a significant diagnosis by hippocampal-subregion interaction (p = .02). Post hoc analysis revealed significantly smaller posterior hippocampi in PTSD (p = .006), with no difference in the volumes of anterior hippocampus or subiculum. No volume differences were found between PTSD participants with prolonged childhood abuse compared to single adult trauma exposure. CONCLUSIONS: The posterior hippocampus has been associated with storage, processing, and retrieval of spatiotemporal memories, central to the protective function of fear conditioning. Volume deficit in the posterior hippocampus may indicate malfunction in this faculty, leading to the exaggerated conditioned fear response observed in PTSD.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4088/jcp.v69n0707

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Still being checked.

Research works printed but not linked: 43

  1. [1]Kitayama N Vaccarino V Kutner M Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis J Affect Disord 2005 Sep 88 1 79 86 16033700
  2. [2]Karl A Schaefer M Malta LS A meta-analysis of structural brain abnormalities in PTSD Neurosci Biobehav Rev 2006 30 7 1004 1031 16730374
  3. [3]Vythilingam M Luckenbaugh DA Lam T Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder Psychiatry Res 2005 Jul 139 2 89 99 15967648
  4. [4]Tischler L Brand SR Stavitsky K The relationship between hippocampal volume and declarative memory in a population of combat veterans with and without PTSD Ann N Y Acad Sci 2006 Jul 1071 405 409 16891587
  5. [5]Yehuda R Golier JA Tischler L Hippocampal volume in aging combat veterans with and without posttraumatic stress disorder: relation to risk and resilience factors J Psychiatr Res 2007 Aug 41 5 435 445 16445942
  6. [6]Blake DD Weathers FW Nagy LM The development of a Clinician-Administered PTSD Scale J Trauma Stress 1995 8 1 75 90 7712061
  7. [7]First MB Spitzer RL Gibbon M Structured Clinical Interview for DSM-IV Washington DC American Psychiatric Press 1997
  8. [8]Bremner JD Vermetten E Mazure CM Development and preliminary psychometric properties of an instrument for the measurement of childhood trauma: the Early Trauma Inventory Depress Anxiety 2000 12 1 1 12 10999240
  9. [9]Rush AJ Gullion CM Basco MR The Inventory of Depressive Symptomatology (IDS): psychometric properties Psychol Med 1996 26 3 477 486 8733206
  10. [10]Hamilton M The assessment of anxiety states by rating Br J Med Psychol 1959 32 50 55 13638508
  11. [12]Bonne O Bain E Neumeister A No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder Am J Psychiatry 2005 Feb 162 2 383 385 15677606
  12. [13]Duvernoy The Human Hippocampus Functional Anatomy, Vascularization and Serial Sections with MRI 2 Berlin, Germany Springer 1998
  13. [14]Golier JA Yehuda R De Santi S Absence of hippocampal volume differences in survivors of the Nazi Holocaust with and without posttraumatic stress disorder Psychiatry Res 2005 May 139 1 53 64 15939577
  14. [15]Neumeister A Wood S Bonne O Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects Biol Psychiatry 2005 Apr 57 8 935 937 15820716
  15. [16]de Geus EJ van’t Ent D Wolfensberger SP Intrapair differences in hippocampal volume in monozygotic twins discordant for the risk for anxiety and depression Biol Psychiatry 2007 May 61 9 1062 1071 17137562
  16. [17]Gilbertson MW Shenton ME Ciszewski A Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma Nat Neurosci 2002 5 11 1242 1247 12379862 PMC2819093
  17. [18]Andreasen NC Flaum M Swayze V 2nd Intelligence and brain structure in normal individuals Am J Psychiatry 1993 Jan 150 1 130 134 8417555
  18. [19]Juengling FD Schmahl C Hesslinger B Positron emission tomography in female patients with borderline personality disorder J Psychiatr Res 2003 Mar–Apr 37 2 109 115 12842164
  19. [20]Tronson NC Taylor JR Molecular mechanisms of memory reconsolidation Nat Rev Neurosci 2007 Apr 8 4 262 275 17342174
  20. [21]Miller GF Chen E Zhou ES If it goes up, must it come down? chronic stress and the hypothalamic pituitary-adrenocortical axis in humans Psychol Bull 2007 Jan 133 1 25 45 17201569
  21. [22]Greicius MD Krasnow B Boyett-Anderson JM Regional analysis of hippocampal activation during memory encoding and retrieval: fMRI study Hippocampus 2003 13 1 164 174 12625466
  22. [23]Lavenex P Amaral DG Hippocampal-neocortical interaction: a hierarchy of associativity Hippocampus 2000 10 4 420 430 10985281
  23. [24]Strange BA Fletcher PC Henson RN Segregating the functions of human hippocampus Proc Natl Acad Sci U S A 1999 Mar 96 7 4034 4039 10097158 PMC22415
  24. [25]Moser MB Moser EI Functional differentiation in the hippocampus Hippocampus 1998 8 6 608 619 9882018
  25. [26]Maguire EA Spiers HJ Good CD Navigation expertise and the human hippocampus: a structural brain imaging analysis Hippocampus 2003 13 2 250 259 12699332
  26. [27]Maguire EA Wollett K Spiers HJ London taxi drivers and bus drivers: a structural MRI and neuropsychological analysis Hippocampus 2006 16 2 1091 1101 17024677
  27. [28]Bast T Zhang WN Feldon J Dorsal hippocampus and classical fear conditioning to tone and context in rats: effects of local NMDA-receptor blockade and stimulation Hippocampus 2003 13 6 657 675 12962312
  28. [29]Matus-Amat P Higgins EA Barrientos RM The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations J Neurosci 2004 Mar 24 10 2431 2439 15014118 PMC6729490
  29. [30]Rasmusson AM Shi L Duman R Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock Neuropsychopharmacology 2002 27 2 133 142 12093587
  30. [31]Barrientos RM Sprunger DB Campeau S BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration J Neuroimmunol 2004 Oct 155 1–2 119 126 15342202
  31. [32]Anagnostaras SG Gale GD Fanselow MS Hippocampus and contextual fear conditioning: recent controversies and advances Hippocampus 2001 11 1 8 17 11261775
  32. [33]Grillon C Morgan CA III Fear-potentiated startle conditioning to explicit and contextual cues in Gulf War veterans with posttraumatic stress disorder J Abnorm Psychol 1999 108 1 134 142 10066999
  33. [34]Joca SR Padovan CM Guimarães FS Activation of postsynaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development Brain Res 2003 Jul 978 1–2 177 184 12834912
  34. [35]Malberg JE Duman RS Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment Neuropsychopharmacology 2003 Sep 28 9 1562 1571 12838272
  35. [36]Robertson DA Beattie JE Reid IC Regulation of corticosteroid receptors in the rat brain: the role of serotonin and stress Eur J Neurosci 2005 Mar 21 6 1511 1520 15845079
  36. [37]Rami A Ausmeir F Wineckler J Differential effects of scopolamine on neuronal survival in ischemia and glutamate neurotoxicity: relationships to the excessive vulnerubility of the dorsoseptal hippocampus J Chem Neuroanat 1997 Aug 13 3 201 208 9315969
  37. [38]Lipton P Ischemic cell death in brain neurons Physiol Rev 1999 Oct 79 4 1431 1568 10508238
  38. [39]Smith ML Auer RN Siesjö BK The density and distribution of ischemic brain injury in the rat following 2–10min of forebrain ischemia Acta Neuropathol 1984 64 4 319 332 6507048
  39. [40]Hartman RE Lee JM Zipfel GJ Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in rats Brain Res 2005 May 1043 1–2 48 56 15862517
  40. [41]Lee AL Ogle WO Sapolsky RM Stress and depression: possible links to neuron death in the hippocampus Bipolar Disord 2002 Apr 4 2 117 128 12071509
  41. [42]McEwen BS Protective and damaging effects of stress mediators: central role of the brain Dialogues Clin Neurosci 2006 8 4 367 381 17290796 PMC3181832
  42. [43]Yehuda R Biology of posttraumatic stress disorder J Clin Psychiatry 2000 61 suppl 7 14 21 10795605
  43. [44]Martin SB Covell DJ Joseph JE Human experience seeking correlates with hippocampus volume: convergent evidence from manual tracing and voxel-based morphometry Neuropsychologia 2007 Sep 45 12 2874 2881 17603086 PMC2971547

Cited by

Sorted by citations

Items 101–156 of 156

Related

See all

Metadata

Authors
Bonne, O., Vythilingam, M., Inagaki, M., Wood, S., Neumeister, A., Nugent, A. C., Snow, J., Luckenbaugh, D. A., Bain, E. E., Drevets, W. C., & Charney, D. S.
Affiliations
  • Hadassah Medical Center (IL)
  • National Institutes of Health (US)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2008-07-15
Volume
69
Issue
7
Pages
1087-1091
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.v69n0707
PMC
PMC2684983
OpenAlex
W2018570780
Cited by
156
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 12 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 7 · 2015: 13 · 2014: 10 · 2013: 9 · 2012: 12
FWCI
13.01
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (Z01MH002789)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
post-traumatic stress disorder, hippocampal volume, posterior hippocampus, hippocampal subfields, subiculum, childhood abuse, adult trauma, fear conditioning, spatiotemporal memory, brain atrophy
MeSH terms
Adult, Anxiety Disorders, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Severity of Illness Index, Stress Disorders, Post-Traumatic, Time Factors, Imaging, Three-Dimensional, Diagnostic and Statistical Manual of Mental Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review