Relationship of Hippocampal Volumes and Posttraumatic Stress Disorder Symptoms Over Early Posttrauma Periods
Open accessAbstract
Background Smaller hippocampal volume is associated with more severe posttraumatic stress disorder (PTSD) symptoms years after traumatic experiences. Posttraumatic stress symptoms appear early following trauma, but the relationship between hippocampal volume and PTSD symptom severity during early posttrauma periods is not well understood. It is possible that the inverse relationship between hippocampal volume and PTSD symptom severity is already present soon after trauma. To test this possibility, we prospectively examined the association between hippocampal volumes and severity of PTSD symptoms within weeks to months after trauma due to a motor vehicle collision. Methods Structural magnetic resonance imaging scans of 44 survivors were collected about 2 weeks and again at 3 months after a motor vehicle collision to measure hippocampal volumes. The PTSD Checklist was used to evaluate PTSD symptoms at each scan time. Full (n = 5) or partial (n = 6) PTSD was evaluated using the Clinician-Administered PTSD Scale at 3 months. Results Left hippocampal volumes at both time points negatively correlated with PTSD Checklist scores, and with subscores for re-experiencing symptoms at 3 months. Left hippocampal volumes at 3 months also negatively correlated with hyperarousal symptoms at 3 months. Finally, neither left nor right hippocampal volumes significantly changed between 2 weeks and 3 months posttrauma. Conclusions The results suggest that small hippocampal volume at early posttrauma weeks is associated with increased risk for PTSD development. Furthermore, the inverse relationship between hippocampal volume and PTSD symptoms at 3 months did not arise from posttrauma shifts in hippocampal volume between 2 weeks and 3 months after trauma.
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fMRI on a sample of 44 people who had survived a traffic accident showed a correlation between lower hippocampal volumes assessed in post-seizure weeks and increased risk for PTSD development.
“The results of fMRI on the sample of 44 people who had survived a traffic accident, showed a correlation between lower hippocampal volumes assessed in post-seizure weeks, and increased risk for PTSD development (Xie et al., 2017).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Xie et al., 2017
The Abstract Methods report structural MRI of 44 motor-vehicle-collision survivors about two weeks and three months after the crash. The Conclusion says early left hippocampal volume may predict later PTSD symptom severity. The claim incorrectly calls the imaging fMRI and the period “post-seizure”; it also describes increased risk of developing PTSD more strongly than the reported association with symptoms warrants. (LLM, conf=0.90)
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Cites
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
Fischl, B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.021 · Cited by 9,526 · see citing works
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Psychometric properties of the PTSD checklist (PCL)
Blanchard, E. B., Jones-Alexander, J., Buckley, T. C., & Forneris, C. A. (1996) · Behaviour Research and Therapy · doi:10.1016/0005-7967(96)00033-2 · Cited by 3,997 · see citing works
Definition of mild traumatic brain injury
&NA;, &. (1993) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-199309000-00010 · Cited by 1,910 · see citing works
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn958 · Cited by 1,635 · see citing works
Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529 · see citing works
Self-citationKing, N. S., Crawford, S., Wenden, F. J., Moss, N. E. G., & Wade, D. T. (1995) · Journal of Neurology · doi:10.1007/bf00868811 · Cited by 1,460 · see citing works
Posttraumatic stress disorder: the burden to the individual and to society.
Kessler, R. C. (2000) · PubMed · Cited by 1,443 · see citing works
Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., & Charney, D. S. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00162-x · Cited by 1,283 · see citing works
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203 · see citing works
Milad, M. R., Wright, C. I., Orr, S. P., Pitman, R. K., Quirk, G. J., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.011 · Cited by 1,197 · see citing works
Gurvits, T. V., Shenton, M. E., Hokama, H., Ohta, H., Lasko, N. B., Gilbertson, M. W., Orr, S. P., Kikinis, R., Jolesz, F. A., McCarley, R. W., et al. (1996) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00229-6 · Cited by 899 · see citing works
The Descriptive Epidemiology of Commonly Occurring Mental Disorders in the United States
Kessler, R. C., & Wang, P. S. (2008) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.29.020907.090847 · Cited by 888 · see citing works
The functional neuroanatomy of PTSD: a critical review
Liberzon, I., & Sripada, C. S. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67011-3 · Cited by 594 · see citing works
Self-citationA cognitive neuroscience account of posttraumatic stress disorder and its treatment
Brewin, C. R. (2001) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(00)00087-5 · Cited by 588 · see citing works
Vermetten, E., Vythilingam, M., Southwick, S. M., Charney, D. S., & Bremner, J. D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00634-6 · Cited by 487 · see citing works
Logue, M. W., van Rooij, S. J. H., Dennis, E. L., Davis, S. L., Hayes, J. P., Stevens, J. S., Densmore, M., Haswell, C. C., Ipser, J., Koch, S. B. J., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.006 · Cited by 487 · see citing works
Self-citationYehuda, R., McFarlane, A. C., & Shalev, A. Y. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00276-5 · Cited by 478 · see citing works
The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?
Godsil, B. P., Kiss, J., Spedding, M., & Jay, T. M. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.10.018 · Cited by 434 · see citing works
Longitudinal MRI Study of Hippocampal Volume in Trauma Survivors With PTSD
Bonne, O. B., Brandes, D., Gilboa, A., Gomori, J. M., Shenton, M. E., Pitman, R. K., & Shalev, A. Y. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1248 · Cited by 430 · see citing works
Context Processing and the Neurobiology of Post-Traumatic Stress Disorder
Liberzon, I., & Abelson, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.039 · Cited by 420 · see citing works
Self-citationReduced hippocampal volume and total white matter volume in posttraumatic stress disorder
Villarreal, G., Hamilton, D. A., Petropoulos, H., Driscoll, I., Rowland, L. M., Griego, J. A., Kodituwakku, P. W., Hart, B. L., Escalona, R., & Brooks, W. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01359-8 · Cited by 382 · see citing works
Garfinkel, S. N., Abelson, J. L., King, A. P. J., Sripada, R. K., Wang, X., Gaines, L. M., & Liberzon, I. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4287-13.2014 · Cited by 361 · see citing works
Self-citationScan–rescan reliability of subcortical brain volumes derived from automated segmentation
Morey, R. A., Selgrade, E. S., Wagner, H. R., Huettel, S. A., Wang, L., & McCarthy, G. (2010) · Human Brain Mapping · doi:10.1002/hbm.20973 · Cited by 210 · see citing works
Partial posttraumatic stress disorder revisited
Mylle, J. J. C., & Maes, M. H. J. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00218-5 · Cited by 197 · see citing works
Pain in the aftermath of trauma is a risk factor for post-traumatic stress disorder
Norman, S. B., Stein, M. B., Dimsdale, J. E., & Hoyt, D. B. (2007) · Psychological Medicine · doi:10.1017/s0033291707001389 · Cited by 189 · see citing works
Lindauer, R., Olff, M., van Meijel, E. P. M., Carlier, I. V. E., & Gersons, B. P. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.033 · Cited by 179 · see citing works
van Rooij, S. J. H., Kennis, M., Sjouwerman, R., van den Heuvel, M. P., Kahn, R. S., & Geuze, E. (2015) · Psychological Medicine · doi:10.1017/s0033291715000707 · Cited by 145 · see citing works
Levy‐Gigi, E., Szabó, C. A., Kelemen, O., & Kéri, S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.017 · Cited by 143 · see citing works
Apfel, B. A., Ross, J., Hlavin, J., Meyerhoff, D. J., Metzler, T. J., Marmar, C. R., Weiner, M. W., Schuff, N., & Neylan, T. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.044 · Cited by 139 · see citing works
Galatzer-Levy, I. R., Ankri, Y., Freedman, S., Israeli-Shalev, Y., Roitman, P., Gilad, M., & Shalev, A. Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070084 · Cited by 137 · see citing works
Early Life Stress Effects on Glucocorticoid—BDNF Interplay in the Hippocampus
Daskalakis, N. P., de Kloet, E. R., Yehuda, R., Malaspina, D., & Kranz, T. M. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00068 · Cited by 134 · see citing works
Nakao (2005) · doi:10.1016/j.pscychresns.2005.04.003 · Cited by 132 · see citing works
Milani, A. C. C., Hoffmann, E. V., Fossaluza, V., Jackowski, A. P., & Mello, M. F. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12473 · Cited by 128 · see citing works
Brain structural changes as vulnerability factors and acquired signs of post-earthquake stress
Sekiguchi, A., Sugiura, M., Taki, Y., Kotozaki, Y., Nouchi, R., Takeuchi, H., Araki, T., Hanawa, S., Nakagawa, S., Miyauchi, C. M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.51 · Cited by 114 · see citing works
Blanchard, E. B., Hickling, E. J., Taylor, A. E., Forneris, C. A., Loos, W. R., & Jaccard, J. J. (1995) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)00064-q · Cited by 102 · see citing works
Biomarkers in Posttraumatic Stress Disorder: Overview and Implications for Future Research
Schmidt, U., Kaltwasser, S. F., & Wotjak, C. T. (2013) · Disease Markers · doi:10.1155/2013/835876 · Cited by 100 · see citing works
Duration of posttraumatic stress disorder predicts hippocampal grey matter loss
Felmingham, K. L., Williams, L. M., Whitford, T. J., Falconer, E. M., Kemp, A. H., Peduto, A. J., & Bryant, R. A. (2009) · Neuroreport · doi:10.1097/wnr.0b013e3283300fbc · Cited by 98 · see citing works
Levy-Gigi, E., Szabo, C., Richter-Levin, G., & Kéri, S. (2015) · Neuropsychology · doi:10.1037/neu0000131 · Cited by 85 · see citing works
Greater hippocampal volume is associated with PTSD treatment response
Rubin, M., Shvil, E., Papini, S., Thapa-Chhetry, B., Helpman, L., Markowitz, J. C., Mann, J. J., & Neria, Y. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.05.001 · Cited by 83 · see citing works
Hippocampal volume and the rapid antidepressant effect of ketamine
Abdallah, C. G., Salas, R., Jackowski, A., Baldwin, P., Sato, J. R., & Mathew, S. J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114544776 · Cited by 78 · see citing works
Hippocampal but not amygdalar volume affects contextual fear conditioning in humans
Pohlack, S. T., Nees, F., Liebscher, C., Cacciaglia, R., Diener, S. J., Ridder, S., Woermann, F. G., & Flor, H. (2011) · Human Brain Mapping · doi:10.1002/hbm.21224 · Cited by 69 · see citing works
Dickstein, B. D., Weathers, F. W., Angkaw, A. C., Nievergelt, C. M., Yurgil, K. A., Nash, W. P., Baker, D. G., Litz, B. T., & the Marine Resiliency Study Team (2014) · Assessment · doi:10.1177/1073191114548683 · Cited by 68 · see citing works
Hippocampal Volume Change in Schizophrenia
Koolschijn, P. C. M. P., van Haren, N. E. M., Cahn, W., Schnack, H. G., Janssen, J., Klumpers, F., Pol, H. E. H., & Kahn, R. S. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04574yel · Cited by 58 · see citing works
Emdad, R., Bonekamp, D., Söndergaard, H. P., Björklund, T., Agartz, I., Ingvar, M., & Theorell, T. (2006) · Psychotherapy and Psychosomatics · doi:10.1159/000090897 · Cited by 55 · see citing works
Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder
Chao, L. L., Weiner, M. W., & Neylan, T. C. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.03.002 · Cited by 53 · see citing works
Hippocampal volume is inversely related to PTSD duration
Chao, L. L., Yaffe, K. S., Samuelson, K. W., & Neylan, T. C. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.03.005 · Cited by 49 · see citing works
Preliminary Study of Acute Changes in Emotion Processing in Trauma Survivors with PTSD Symptoms
Wang, X., Xie, H., Cotton, A. S., Duval, E. R., Tamburrino, M., Brickman, K. R., Elhai, J. D., Ho, S.-H. S., McLean, S. A., Ferguson, E. J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159065 · Cited by 38 · see citing works
Self-citationGalatzer‐Levy, I. R., Ankri, Y. L. E., Freedman, S., Israeli-Shalev, Y., Roitman, P., Gilad, M., & Shalev, A. Y. (2013) · PLoS ONE · doi:10.1371/annotation/0af0b6c6-ac23-4fe9-a692-f5c30a3a30b3 · Cited by 28 · see citing works
Can FreeSurfer Compete with Manual Volumetric Measurements in Alzheimer's Disease?
Clerx, L., Gronenschild, E. H. B. M., Echávarri, C., FransVerhey, Aalten, P., & Jacobs, H. I. L. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150324174813 · Cited by 23 · see citing works
Resilience after 3/11: structural brain changes 1 year after the Japanese earthquake
Sekiguchi, A., Kotozaki, Y., Sugiura, M., Nouchi, R., Takeuchi, H., Hanawa, S., Nakagawa, S., Miyauchi, C. M., Araki, T., Sakuma, A., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.28 · Cited by 16 · see citing works
Updates in the neuroendocrinology of stress and its clinical management
Quijije, N. V. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000176 · Cited by 12 · see citing works
A systematic review of the PTSD Checklist’s diagnostic accuracy studies using QUADAS.
McDonald, S. D., Brown, W. L., Benesek, J., & Calhoun, P. S. (2014) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000001 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 56 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- [3]Swedish Council on Health Technology Assessment 2005 SBU Systematic Review Summaries Treatment of Anxiety Disorders: A Systematic Review Stockholm Swedish Council on Health Technology Assessment (SBU) 28876726
- [9]Logue MW van Rooij SJH Dennis EL Davis SL Hayes JP Stevens JS Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multi-Site ENIGMA-PGC Study Biol Psychiatry In press PMC5951719 29217296
- [16]Vythilingam M Luckenbaugh DA Lam T Morgan CA 3rd Lipschitz D Charney DS 2005 Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder Psychiatry Res 139 89 99 15967648
- [35]Fischl B 2012 FreeSurfer NeuroImage 62 774 781 22248573 PMC3685476
Cited by
Sorted by citations
Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408 · see citing works
“This concept has been demonstrated in an MRI study of PTSD which showed how smaller hippocampal volume predicted risk of PTSD and did not result from the trauma that triggered PTSD [71].”
BackgroundNeural contributors to trauma resilience: a review of longitudinal neuroimaging studies
Roeckner, A. R., Oliver, K. I., Lebois, L. A. M., van Rooij, S. J. H., & Stevens, J. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01633-y · Cited by 103 · see citing works
Henigsberg, N., Kalember, P., Petrović, Z. K., & Šečić, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.003 · Cited by 105 · see citing works
Sex-Based Contributors to and Consequences of Post-traumatic Stress Disorder
Hiscox, L. V., Sharp, T. H., Olff, M., Seedat, S., & Halligan, S. L. (2023) · Current Psychiatry Reports · doi:10.1007/s11920-023-01421-z · Cited by 60 · see citing works
Hinojosa, C. A., George, G. C., & Ben‐Zion, Z. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02558-w · Cited by 60 · see citing works
Xiao, L., Liu, S., Wu, Y., Huang, Y., Tao, S., Liu, Y., Tang, Y., Xie, M., Ma, Q., Yin, Y., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.003 · Cited by 45 · see citing works
Bremner, J. D., Hoffman, M., Afzal, N., Cheema, F. A., Novik, O., Ashraf, A., Brummer, M. E., Nazeer, A., Goldberg, J. H., & Vaccarino, V. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.10.042 · Cited by 44 · see citing works
Longitudinal volumetric evaluation of hippocampus and amygdala subregions in recent trauma survivors
Ben‐Zion, Z., Korem, N., Spiller, T. R., Duek, O. A., Keynan, J. N., Admon, R., Harpaz‐Rotem, I., Liberzon, I., Shalev, A. Y., & Hendler, T. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01842-x · Cited by 41 · see citing works
Self-citationXie, H., Huffman, N., Shih, C.-H., Cotton, A. S., Buehler, M., Brickman, K. R., Wall, J. T., & Wang, X. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111421 · Cited by 38 · see citing works
Self-citationMonari, S., de Suduiraut, I. G., Grosse, J., Zanoletti, O., Walker, S. E., Mesquita, M. S., Wood, T., Cash, D., Astori, S., & Sandi, C. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.09.015 · Cited by 32 · see citing works
Weis, C., Webb, E. K., Huggins, A. A., Kallenbach, M. D., Miskovich, T. A., Fitzgerald, J. M., Bennett, K. P., Krukowski, J. L., deRoon‐Cassini, T. A., & Larson, C. L. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118076 · Cited by 30 · see citing works
Jiang, Y., Wang, X., Li, X., Liu, A., Fan, Q., Yang, L., Feng, B., Zhang, K., Lu, L., Qi, J., et al. (2022) · Phytotherapy Research · doi:10.1002/ptr.7540 · Cited by 24 · see citing works
Self-citationQuidé, Y., Andersson, F., Dufour‐Rainfray, D., Descriaud, C., Brizard, B., Gissot, V., Cléry, H., Bas, M. C. L., Osterreicher, S., Ogielska, M., et al. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12920 · Cited by 24 · see citing works
Kim, E.-G., Chang, W., Shin, S., Adhikari, A. S., Seol, G. H., Song, D., & Min, S. S. (2022) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2023.27.1.113 · Cited by 21 · see citing works
How Psychedelics Modulate Multiple Memory Mechanisms in Posttraumatic Stress Disorder
Doss, M. K., DeMarco, A., Dunsmoor, J. E., Cisler, J. M., Fonzo, G. A., & Nemeroff, C. B. (2024) · Drugs · doi:10.1007/s40265-024-02106-4 · Cited by 21 · see citing works
Picci, G., Christopher‐Hayes, N. J., Petro, N. M., Taylor, B. K., Eastman, J. A., Frenzel, M. R., Wang, Y., Stephen, J. M., Calhoun, V. D., & Wilson, T. W. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100456 · Cited by 15 · see citing works
Huffman, N., Shih, C.-H., Cotton, A. S., Lewis, T. J., Grider, S. R., Wall, J. T., Wang, X., & Xie, H. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1147686 · Cited by 15 · see citing works
Self-citationSex-dependent risk factors for PTSD: a prospective structural MRI study
Roeckner, A. R., Sogani, S., Michopoulos, V., Hinrichs, R. C., van Rooij, S. J. H., ROTHBAUM, B. O., Jovanović, T., Ressler, K. J., & Stevens, J. S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01452-9 · Cited by 14 · see citing works
Weaving Invisible Threads: The Impact of Caregiver Trauma on Parenting and Child Brain Development
Riser, M., Trentacosta, C. J., & Jovanović, T. (2025) · Brain Sciences · doi:10.3390/brainsci15070726 · Cited by 14 · see citing works
Trauma and the default mode network: review and exploratory study
Chan, A., Harvey, P. D., Hernandez-Cardenache, R., Alperin, N. J., Lee, S. H., Hunt, C., Petersen, N., Northoff, G., Robertson, N., Ouyang, J., et al. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1499408 · Cited by 13 · see citing works
Does Hippocampal Volume in Patients with Posttraumatic Stress Disorder Vary by Trauma Type?
Hinojosa, C. A. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000328 · Cited by 11 · see citing works
Devignes, Q., Ren, B., Clancy, K. J., Howell, K., Pollmann, Y., Martinez-Sanchez, L., Beard, C., Kumar, P., & Rosso, I. M. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02795-1 · Cited by 8 · see citing works
Winters, J. J., Hardy, L. W., Sullivan, J. M., Powell, N. A., Qutaish, M. Q., Nair, S., Heimann, J., Ghayoor, A., Polyak, I., Chaby, L. E., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112902 · Cited by 10 · see citing works
Self-citationQiu-xiang, S., Liu, M., Jiang, M., Wang, Y., Ma, X., Li, S., & Xie, J. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-05055-4 · Cited by 8 · see citing works
Kosaraju, S., Galatzer‐Levy, I. R., Schultebraucks, K., Winters, S., Hinrichs, R. C., Reddi, P. J., Maples‐Keller, J. L., Hudak, L. A., Michopoulos, V., Jovanović, T., et al. (2022) · Journal of Traumatic Stress · doi:10.1002/jts.22858 · Cited by 6 · see citing works
Nkrumah, R., von Schröder, C., Demirakca, T., Schmahl, C., & Ende, G. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100586 · Cited by 8 · see citing works
Haering, S., Schulze, L., Geiling, A., Meyer, C., Klusmann, H., Schumacher, S., Knaevelsrud, C., & Engel, S. (2022) · doi:10.31234/osf.io/ad35g · Cited by 5 · see citing works
Nikolenko, V. N., Osadchiy, A. S., Lobanova, A., Isakova, T. A., Zharov, N. A., & Zharova, N. V. (2024) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2024-2-69-75 · Cited by 4 · see citing works
Stewart, R., Brahimi, X., Iadipaolo, A. S., Peters, C. A., Harper, F. W. K., Taub, J. W., Rabinak, C. A., & Marusak, H. A. (2020) · Adversity and Resilience Science · doi:10.1007/s42844-020-00016-4 · Cited by 3 · see citing works
Moving beyond gender: a systematic review of diversity data gaps in prospective trauma research
Haering, S., Kaeselau, J. M., Knaevelsrud, C., & Engel, S. (2025) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2537544 · Cited by 2 · see citing works
The impact of disaster on cognition in geriatric population
Önder, Ö. (2024) · Health Sciences Quarterly · doi:10.26900/hsq.2243 · Cited by 3 · see citing works
Willing, M. M. P., Srikanchana, R. A., Pickett, T. C., Ollinger, J. M., Riggs, D. S., Werner, J. K., & Rhodes, C. S. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2022.111546 · Cited by 2 · see citing works
Lee, J., Lee, E., Kim, B., Kim, G., Joo, Y. Y., & Cha, J. (2024) · medRxiv · doi:10.1101/2024.03.04.24303643 · Cited by 2 · see citing works
Shih, C.-H., Feuer, E., Kurzion, B., Xu, K. S., Xie, H., Grider, S. R., & Wang, X. (2025) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2458365 · Cited by 1 · see citing works
Self-citationRoss, J., Cuccurazzu, B., Delmar, D., Cortez, C., Castillo, G., Acheson, D. T., Baker, D. G., Risbrough, V. B., & Stout, D. M. (2025) · npj Mental Health Research · doi:10.1038/s44184-025-00126-w · Cited by 1 · see citing works
Evanski, J. M., Iadipaolo, A. S., Ely, S. L., Zundel, C. G., Gowatch, L. C., Bhogal, A., Owens, Z., Cohen, C., Goldberg, E., Bluth, M. H., et al. (2023) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acad056 · Cited by 1 · see citing works
Kapıcı, O. B., Kapıcı, Y., Örüm, D., Örüm, M. H., & Şırık, M. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06763-x · Cited by 1 · see citing works
Sobre la atrofia hereditaria del nervio óptico. (Enfermedad de Leber)
Meyer-Riemsloh, B., & Zabaleta, H. O. (1926) · Archivos de Oftalmología Hispano-Americanos
Psychometric Concerns in the Assessment of Trauma-Related Symptoms in Older Adults
van Zelst, W. H., & Beekman, A. T. F. (2020) · doi:10.1093/oxfordhb/9780190088224.013.21
Marusak, H. A., Evanski, J. M., Iadipaolo, A. S., Ely, S. L., Zundel, C. G., Gowatch, L. C., Bhogal, A., Owens, Z., Cohen, C., Goldberg, E., et al. (2023) · doi:10.22541/au.167463191.13025153/v1
Estimating Dynamic Posttraumatic Stress Symptom Trajectories with Functional Data Analysis
Shih, C.-H., Premathilaka, M., Xie, H., Wang, X., & Liu, R. (2023) · Lecture notes in computer science · doi:10.1007/978-3-031-43075-6_30
Self-citationHaering, S., Meyer, C., Schulze, L., Conrad, E., Blecker, M. K., El‐Haj‐Mohamad, R., Geiling, A., Klusmann, H., Schumacher, S., Knaevelsrud, C., et al. (2023) · doi:10.31234/osf.io/hfqt2
Prefrontal Cortical Deficits are a Putative Susceptibility Factor for PtsdPreprint
Vazdarjanova, A. I., Nalloor, R. I., & Shanazz, K. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5253357
Du, E. Y., & Tian, J. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251400775
Prefrontal cortical deficits are a putative susceptibility factor for PTSD
Nalloor, R., Shanazz, K., & Vazdarjanova, A. I. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1750991
Yates, J. R. (2026) · Springer eBooks · doi:10.1007/978-3-032-15602-0_6
- Authors
- Xie, H., Claycomb Erwin, M., Elhai, J. D., Wall, J. T., Tamburrino, M. B., Brickman, K. R., Kaminski, B., McLean, S. A., Liberzon, I., & Wang, X.
- Affiliations
- University of Toledo (US)
- ProMedica Toledo Hospital (US)
- University of North Carolina at Chapel Hill (US)
- University of Michigan (US)
- Corresponding author
- Wang, Xin
- ORCID
- Venue
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 3
- Issue
- 11
- Pages
- 968-975
- ISSN
- 2451-9022 (ISSN-L)
- PMC
- PMC6233727
- OpenAlex
- W2775792590
- Cited by
- 49
- References
- 56
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 2
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R21MH098198-02, R01MH110483-01A1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hippocampal volume, post-traumatic stress disorder, traffic accidents, re-experiencing symptoms, hyperarousal symptoms, traumatic brain injury, hippocampal atrophy, PTSD risk
- MeSH terms
- Adolescent, Adult, Depressive Disorder, Major, Major Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic, Temporal Lobe, Time Factors, Survivors, Young Adult
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