A Case Report of Onset of Tinnitus Following Discontinuation of Antidepressant and a Review of the Literature
Open accessAbstract
This case report describes a 46-year-old woman with long-standing episodic severe depression (ICD-10 code F33) who discontinued venlafaxine over a 4-week taper after taking the antidepressant for 8 years. Severe discontinuation syndrome was experienced. Panic and relapse of depression occurred 2 months after achieving discontinuation, and the development of tinnitus took place concurrently to the discontinuation. The experience of the tinnitus as a side effect of discontinuation is different from cases reported in the literature in which the tinnitus was experienced when the antidepressant was started and ceased when the antidepressant was stopped. Here, the patient experienced the tinnitus as a discontinuation symptom, and it persisted even after the antidepressant was reintroduced. A review of the literature on antidepressant discontinuation syndrome is also provided.
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In Stein et al. and Montgomery et al., discontinuation symptoms in patients switched to placebo were similar to those of patients maintained on agomelatine.
“In Stein et al. [107] and in Montgomery et al. [108], discontinuation symptoms in patients switched to placebo were similar to those of patients maintained on agomelatine.”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [108]
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- Authors
- Clewes, J.
- Affiliations
- North Staffordshire Combined Healthcare NHS Trust (GB)
- Corresponding author
- Clewes, Jane
- Venue
- The Primary Care Companion For CNS Disorders
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2012-02-16
- Volume
- 14
- Issue
- 1
- ISSN
- 2155-7772 (ISSN-L)
- 2155-7780
- PMC
- PMC3357564
- OpenAlex
- W2055900847
- Cited by
- 16
- References
- 13
- Citations by year
- 2025: 3 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2014: 2 · 2012: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Primary Care Companion For CNS Disorders (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- tinnitus, antidepressant discontinuation syndrome, venlafaxine, depression, drug discontinuation, adverse drug reactions, antidepressant tapering, depression relapse
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