A Review of Butyrylcholinesterase as a Therapeutic Target in the Treatment of Alzheimer’s Disease
Nordberg, Agneta, Ballard, Clive, Bullock, Roger, Darreh-Shori, Taher, Somogyi, Monique·2013·The Primary Care Companion For CNS Disorders
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- Potential Utilization of Natural Anthraquinone Aglycone Emodin for Alzheimer's Disease: A Comprehensive Review With Computational InsightsSalehin Sheikh, Faysal Mollah, Raihan Chowdhury, Most. Israt Jahan Oni, Mst Muslima Khatun, Md. Shadin, Md. Shimul Bhuia, Md Arshadul Hoque, Mohamed Alfaifi, Faisal H. Altemani et al. · 2026 · ChemistrySelect
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- Light spectrum effects on huperzine A and B accumulation in axenic gametophyte cultures of Huperzia selago (L.) Bernh. ex Schrank et MartWojciech J. Szypuła, Marta Maciejczyk, Beata Wileńska · 2026 · Frontiers in Plant Science
- Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodentsPatrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth Brian Miles, Laskaro Zagoraiou et al. · 2026 · British Journal of Pharmacology
- BindingDB Entry 50015599: A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50047275: Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.BindingDB · 2017 · UC San Diego
- BindingDB Entry 50049120: Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.BindingDB · 2019 · UC San Diego
- BindingDB Entry 50001887: Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50003266: Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50047319: Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.BindingDB · 2017 · UC San Diego
- BindingDB Entry 50007389: Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50011384: TBABindingDB · 2022 · UC San Diego
- BindingDB Entry 50000270: Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.BindingDB · 2019 · UC San Diego
- BindingDB Entry 50008501: 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50013954: Design and synthesis of garlic-related unsymmetrical thiosulfonates as potential Alzheimer's disease therapeutics: In vitro and in silico study.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50010733: Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50012362: Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50013955: Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50001419: Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50007333: Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50002429: The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50046826: Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50022809: Chromenone: An emerging scaffold in anti-Alzheimer drug discovery.BindingDB · 2026 · UC San Diego
- BindingDB Entry 50013172: Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal structure and in-vitro biological evaluation.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50014707: Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HTBindingDB · 2022 · UC San Diego
- BindingDB Entry 50007930: Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50008884: Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50017722: From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50022005: Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50044755: Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-ß aggregation and to exert anticholinesterase and antioxidant effects.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50000730: Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.BindingDB · 2020 · UC San Diego
- BindingDB Entry 50007468: Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50012241: Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50020080: Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents:BindingDB · 2024 · UC San Diego