CoChat
Sign Up
Cited by 34Physical Activity and HealthAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women

Open access
Jeon, Yun Kyung, Kim, Sang Soo, Kim, Jong Ho, Kim, Hyun Jeong, Kim, Hyun Jun, Park, Jang Jun, Cho, Yuen Suk, Joung, So Hee +6 more·2020·Diabetes & Metabolism Journal
DOI 10.4093/dmj.2018.0160PMC PMC7043986
Open this paper in CoChat — free accountOpen PDF

Abstract

Background: Circulating apolipoprotein J (ApoJ) is closely associated with insulin resistance; however, the effect of exercise on circulating ApoJ levels and the association of ApoJ with metabolic indices remain unknown.Here, we investigated whether a combined exercise can alter the circulating ApoJ level, and whether these changes are associated with metabolic indices in patients with type 2 diabetes mellitus.Methods: Postmenopausal women with type 2 diabetes mellitus were randomly assigned into either an exercise (EXE, n=30) or control (CON, n=15) group.Participants in the EXE group were enrolled in a 12-week program consisting of a combination of aerobic and resistance exercises.At baseline, 4, 8, and 12 weeks, body composition and metabolic parameters including homeostatic model assessment of insulin resistance (HOMA-IR) and serum ApoJ levels were assessed.Results: In the EXE group, ApoJ levels decreased 26.3% and 19.4%, relative to baseline, at 8 and 12 weeks, respectively.Betweengroup differences were significant at 8 and 12 weeks (P<0.05 and P<0.001, respectively).In the EXE group, 12 weeks of exercise resulted in significant decreases in body weight, percent body fat, and HOMA-IR indices.Concurrently, weight-adjusted appendicular skeletal muscle mass (ASM/wt) was increased in the EXE group compared with the CON group.Importantly, changes in the ApoJ level were significantly correlated with changes in ASM/wt.Conclusion: Exercise training resulted in a significant decrease in the circulating ApoJ level, with changes in ApoJ associated with an improvement in some insulin resistance indices.These data suggest that circulating ApoJ may be a useful metabolic marker for assessing the effects of exercise on insulin resistance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4093/dmj.2018.0160

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Trials reporting the effects of exercise on apolipoproteins and lipid ratios suggest that exercise training exerts a positive effect on these biomarkers.

    “Trials reporting the effects of exercise on apolipoproteins and lipid ratios suggest that exercise training exerts a positive effect on these biomarkers [23–25]”

    From Estimating the Effect of Aerobic Exercise Training on Novel Lipid Biomarkers: A Systematic Review and Multivariate Meta-Analysis of Randomized Controlled Trials (2023) · cites this paper as [25]

    The Results report that exercise significantly reduced circulating ApoJ, supporting a positive effect on an apolipoprotein biomarker in the postmenopausal women with type 2 diabetes studied. The paper does not report an exercise-related improvement in lipid ratios; its Discussion instead says there was no discernible close relationship between changes in ApoJ and lipid profiles. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 25

  1. [1]Danaei G Finucane MM Lu Y Singh GM Cowan MJ Paciorek CJ Lin JK Farzadfar F Khang YH Stevens GA Rao M Ali MK Riley LM Robinson CA Ezzati M Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants Lancet 2011 378 31 40 21705069
  2. [2]Miller BR Nguyen H Hu CJ Lin C Nguyen QT New and emerging drugs and targets for type 2 diabetes: reviewing the evidence Am Health Drug Benefits 2014 7 452 463 25558307 PMC4280522
  3. [3]Wilcox G Insulin and insulin resistance Clin Biochem Rev 2005 26 19 39 16278749 PMC1204764
  4. [4]Kim YB Nikoulina SE Ciaraldi TP Henry RR Kahn BB Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes J Clin Invest 1999 104 733 741 10491408 PMC408433
  5. [5]Trougakos IP Gonos ES Clusterin/apolipoprotein J in human aging and cancer Int J Biochem Cell Biol 2002 34 1430 1448 12200037
  6. [6]Miwa Y Takiuchi S Kamide K Yoshii M Horio T Tanaka C Banno M Miyata T Sasaguri T Kawano Y Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females Biochem Biophys Res Commun 2005 331 1587 1593 15883054
  7. [7]Thambisetty M Simmons A Velayudhan L Hye A Campbell J Zhang Y Wahlund LO Westman E Kinsey A Guntert A Proitsi P Powell J Causevic M Killick R Lunnon K Lynham S Broadstock M Choudhry F Howlett DR Williams RJ Sharp SI Mitchelmore C Tunnard C Leung R Foy C O'Brien D Breen G Furney SJ Ward M Kloszewska I Mecocci P Soininen H Tsolaki M Vellas B Hodges A Murphy DG Parkins S Richardson JC Resnick SM Ferrucci L Wong DF Zhou Y Muehlboeck S Evans A Francis PT Spenger C Lovestone S Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease Arch Gen Psychiatry 2010 67 739 748 20603455 PMC3111021
  8. [8]Bi J Guo AL Lai YR Li B Zhong JM Wu HQ Xie Z He YL Lv ZL Lau SH Wang Q Huang XH Zhang LJ Wen JM Guan XY Overexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: a study on tissue microarrays Neoplasma 2010 57 191 197 20353268
  9. [9]Won JC Park CY Oh SW Lee ES Youn BS Kim MS Plasma clusterin (ApoJ) levels are associated with adiposity and systemic inflammation PLoS One 2014 9 e103351 25076422 PMC4116172
  10. [10]Baralla A Sotgiu E Deiana M Pasella S Pinna S Mannu A Canu E Sotgiu G Ganau A Zinellu A Sotgia S Carru C Deiana L Plasma clusterin and lipid profile: a link with aging and cardiovascular diseases in a population with a consistent number of centenarians PLoS One 2015 10 e0128029 26076476 PMC4468059
  11. [11]Hoofnagle AN Wu M Gosmanova AK Becker JO Wijsman EM Brunzell JD Kahn SE Knopp RH Lyons TJ Heinecke JW Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia Arterioscler Thromb Vasc Biol 2010 30 2528 2534 20847305 PMC2988100
  12. [12]Seo JA Kang MC Ciaraldi TP Kim SS Park KS Choe C Hwang WM Lim DM Farr O Mantzoros C Henry RR Kim YB Circulating ApoJ is closely associated with insulin resistance in human subjects Metabolism 2018 78 155 166 28986164 PMC5765540
  13. [13]Zanuso S Jimenez A Pugliese G Corigliano G Balducci S Exercise for the management of type 2 diabetes: a review of the evidence Acta Diabetol 2010 47 15 22 19495557
  14. [14]Oliveira C Simoes M Carvalho J Ribeiro J Combined exercise for people with type 2 diabetes mellitus: a systematic review Diabetes Res Clin Pract 2012 98 187 198 22981711
  15. [15]Colberg SR Sigal RJ Fernhall B Regensteiner JG Blissmer BJ Rubin RR Chasan-Taber L Albright AL Braun B American College of Sports Medicine American Diabetes Association Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement executive summary Diabetes Care 2010 33 2692 2696 21115771 PMC2992214
  16. [16]Way KL Hackett DA Baker MK Johnson NA The effect of regular exercise on insulin sensitivity in type 2 diabetes mellitus: a systematic review and meta-analysis Diabetes Metab J 2016 40 253 271 27535644 PMC4995180
  17. [17]Kim HJ Lee S Kim TW Kim HH Jeon TY Yoon YS Oh SW Kwak H Lee JG Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children Clin Endocrinol (Oxf) 2008 68 416 422 17888020
  18. [19]Trougakos IP Poulakou M Stathatos M Chalikia A Melidonis A Gonos ES Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction Exp Gerontol 2002 37 1175 1187 12470829
  19. [20]Arnold T Brandlhofer S Vrtikapa K Stangl H Hermann M Zwiauer K Mangge H Karwautz A Huemer J Koller D Schneider WJ Strobl W Effect of obesity on plasma clusterin, [corrected] a proposed modulator of leptin action Pediatr Res 2011 69 237 242 21135756
  20. [21]Navab M Anantharamaiah GM Reddy ST Van Lenten BJ Wagner AC Hama S Hough G Bachini E Garber DW Mishra VK Palgunachari MN Fogelman AM An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice Arterioscler Thromb Vasc Biol 2005 25 1932 1937 15961700
  21. [23]Jang HC Sarcopenia, frailty, and diabetes in older adults Diabetes Metab J 2016 40 182 189 27098509 PMC4929221
  22. [24]Kang ES Yun YS Park SW Kim HJ Ahn CW Song YD Cha BS Lim SK Kim KR Lee HC Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea Metabolism 2005 54 206 211 15690315
  23. [25]DeFronzo RA Tobin JD Andres R Glucose clamp technique: a method for quantifying insulin secretion and resistance Am J Physiol 1979 237 E214 E223 382871
  24. [26]Rull A Martinez-Bujidos M Perez-Cuellar M Perez A Ordonez-Llanos J Sanchez-Quesada JL Increased concentration of clusterin/apolipoprotein J (apoJ) in hyperlipemic serum is paradoxically associated with decreased apoJ content in lipoproteins Atherosclerosis 2015 241 463 470 26081122
  25. [27]Aronis KN Vamvini MT Chamberland JP Mantzoros CS Circulating clusterin (apolipoprotein J) levels do not have any day/night variability and are positively associated with total and LDL cholesterol levels in young healthy individuals J Clin Endocrinol Metab 2011 96 E1871 E1875 21900379 PMC3205900

Cited by

Sorted by citations

Authors
Jeon, Y. K., Kim, S. S., Kim, J. H., Kim, H. J., Kim, H. J., Park, J. J., Cho, Y. S., Joung, S. H., Kim, J. R., Kim, B. H., Song, S. H., Kim, I. J., Kim, Y. K., & Kim, Y.-B.
Affiliations
  • Pusan National University Hospital (KR)
  • Beth Israel Deaconess Medical Center (US)
  • Kyungnam University (KR)
  • Pukyong National University (KR)
Corresponding author
  • Kim, Sang Soo
  • Kim, Young-Bum
ORCID
Venue
Diabetes & Metabolism Journal
Publisher
Korean Diabetes Association
Published
2020
Volume
44
Issue
1
Pages
103
ISSN
  • 2233-6079 (ISSN-L)
  • 2233-6087
DOI
10.4093/dmj.2018.0160
PMC
PMC7043986
OpenAlex
W3008496575
Cited by
34
References
2
Citations by year
2026: 4 · 2025: 12 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 4
FWCI
2.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (R01DK111529, R01DK106076)
  • National Research Foundation of Korea (2018R1C1B6002854)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
clusterin, insulin resistance, aerobic exercise, resistance training, concurrent training, type 2 diabetes, postmenopausal women, HOMA-IR, appendicular skeletal muscle mass, body composition
MeSH terms
Aged, Body Composition, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Humans, Insulin Resistance, Middle Aged, Exercise, Postmenopause, Clusterin, Resistance Training

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review