Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients
Open accessAbstract
Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.
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Intermediate levels of daily activity showed the greatest HbA1c reduction in a stratified analysis.
“while intermediate levels of daily activity showed the greatest HbA1c reduction in a stratified analysis [17].”
The effectiveness of wearable devices appears to depend largely on how they are integrated into the overall intervention, particularly in relation to the level of structure, the consistency and nature of behavioural support, and the presence of clearly defined, measurable objectives.
“Their effectiveness appears to depend largely on how they are integrated into the overall intervention, particularly in relation to the level of structure, the consistency and nature of behavioural support, and the presence of clearly defined, measurable objectives [17,20,21,22,23,26,28].”
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Influential
- Authors
- Cirilli, I., Silvestri, S., Marcheggiani, F., Olivieri, F., Galeazzi, R., Antonicelli, R., Recchioni, R., Marcheselli, F., Bacchetti, T., Tiano, L., & Orlando, P.
- Affiliations
- Marche Polytechnic University (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- Corresponding author
- Tiano, Luca
- ORCID
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2019
- Volume
- 43
- Issue
- 6
- Pages
- 893
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- PMC
- PMC6943260
- OpenAlex
- W2953871725
- Cited by
- 19
- References
- 18
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 1 · 2021: 5 · 2020: 2
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, physical activity, exercise monitoring, cardiovascular risk factors, oxidative stress, paraoxonase 1, endothelial function, visceral adipose tissue, blood pressure, microRNA-146a, microRNA-130a, angiogenesis, HbA1c, sedentary lifestyle
- MeSH terms
- Wearable Electronic Devices, Blood Pressure, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Glycated Hemoglobin, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Biomarkers, Exercise, Body Mass Index, MicroRNAs, Aryldialkylphosphatase, Intra-Abdominal Fat
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