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Biomarkers: A potential prognostic tool for silicosis
Open accessAbstract
Long-term exposure to respirable dust containing silica leads to pneumoconiosis/silicosis. The disease is irreversible and incurable, and only preventive steps such as job rotation, use of personal protective equipment, etc., remain solutions to the problem. Under such a situation, early diagnosis or prediction may become very useful to control the disease. Biomarkers are biological parameters in blood serum that change their values with deposition of dust in the lung and onset of lung fibrosis. Since these biomarkers can help us to diagnose and in the prognosis of the disease before it is actually diagnosed by the conventional X-ray technique and lung function test used for diagnosis of silicosis. The present paper describes the various types of available biomarkers, their application and usefulness. The paper also suggests that further study of the behavior/level of these biomarkers on a specific subject with time may provide more useful information of a confirmatory nature for prevention of dust-linked diseases.
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Nonspecific serum markers of inflammation and tumor biomarkers might have utility in screening and/or trending levels of disease severity, though they would help little in ascertaining the diagnosis or determining the level of functional impairment.
“Nonspecific serum markers of inflammation and tumor biomarkers might have utility in screening and/or trending levels of disease severity, though they would help little in ascertaining the diagnosis or determining the level of functional impairment68,69.”
From Overview of lunar dust toxicity risk (2022) · cites this paper as [69]
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Cites
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin
Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988
Choi, A. M., & Alam, J. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.1.8679227 · Cited by 1,126
Elevation of serum angiotension-converting-enzyme (ACE) level in sarcoidosis
Lieberman, J. (1975) · The American Journal of Medicine · doi:10.1016/0002-9343(75)90395-2 · Cited by 872
Carbon monoxide provides protection against hyperoxic lung injury
Otterbein, L. E., Mantell, L. L., & Choi, A. M. K. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.276.4.l688 · Cited by 439
Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II)
Ryan, J. W., Ryan, U. S., Schultz, D. R., Whitaker, C., Chung, A., & Dorer, F. E. (1975) · Biochemical Journal · doi:10.1042/bj1460497 · Cited by 295
Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker
Broeckaert, & Bernard (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00760.x · Cited by 266
Janssen-Heininger, Y. M. W., Macara, I. G., & Mossman, B. T. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.5.3452 · Cited by 200
Reactive oxygen species and silica‐induced carcinogenesis
Shi, X., Castranova, V., Halliwell, B. B., & Vallyathan, V. (1998) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937409809524551 · Cited by 172
SERUM ANGIOTENSIN-CONVERTING ENZYME (SACE) IN SARCOIDOSIS AND OTHER GRANULOMATOUS DISORDERS
Studdy, P. R., Bird, R., James, D. G., & Sherlock, S. (1978) · The Lancet · doi:10.1016/s0140-6736(78)91972-4 · Cited by 165
Gossart, S., Cambon, C., Orfila, C., Séguélas, M., Lepert, J., RAMI, J., Carré, P., & Pipy, B. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.4.1540 · Cited by 163
Selenium and Lung Cancer: A Systematic Review and Meta Analysis
Fritz, H., Kennedy, D. A., Fergusson, D. A., Fernandes, R., Cooley, K., SEELY, A. J. E., Sagar, S. M., Wong, R. K. W., & Seely, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026259 · Cited by 104
Heme Oxygenase-1, a Potential Biomarker of Chronic Silicosis, Attenuates Silica-induced Lung Injury
Sato, T., Takeno, M., Honma, K., Yamauchi, H., Saito, Y., Sasaki, T., Morikubo, H., Nagashima, Y., Takagi, S., Yamanaka, K., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1237oc · Cited by 99
Early decrease of serum Clara cell protein in silica-exposed workers
Bernard, A. M., Gonzalez-Lorenzo, J., Siles, E., Trujillano, G., & Lauwerys, R. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07111932 · Cited by 92
Neopterin as a new biomarker for the evaluation of occupational exposure to silica
Altindag, Z. Z., Baydar, T., Işimer, A., & Şahin, G. (2003) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-003-0434-9 · Cited by 56
Bernard, A., Dumont, X., Roels, H. A., Lauwerys, R., Dierynck, I., LEY, M. D., Stroobant, V., & de Hoffmann, E. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90077-h · Cited by 52
Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis
(1975) · The American Journal of Medicine · doi:10.1016/0002-9343(75)90414-3 · Cited by 52
Increased lysyl oxidase activity in culture medium of nonparenchymal cells from fibrotic livers
Konishi, A., Iguchi, H., Ochi, J., Kinoshita, R., Miura, K., & Uchino, H. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90563-3 · Cited by 16
Serum selenium and selenoprotein P in patients with silicosis
Muzembo, B. A., Dumavibhat, N., Ngatu, N. R., Eitoku, M., Hirota, R., Kondo, S., Deguchi, Y., Saito, Y., Takahashi, K., & Suganuma, N. (2012) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2012.05.003 · Cited by 16
Serum copper levels among quartz stone crushing workers: a cross sectional study.
Tiwari, R. R., Sathwara, N. G., & Saiyed, H. N. (2004) · PubMed · Cited by 7
Flagged first, then by citations
Research works printed but not linked: 6
- Bai, 1993, Changes of trace element copper and zinc in sera of cases with silicosis, Chin J Indian Hyg Occup Dis, 280
- Konishi, 1985, Changes of trace element copper and zinc in sera of cases with silicosis, Gastroenterol, 709
- Ren, 1993, Detection of coal silicosis by radioimmunoassay used for ceruloplasmin, Chin J Ind Hyg Occup Dis, 145
- Prakova, 2005, The potential role of neopterin as a biomarker for silicosis, Trakia J Sci, 37
- Wang, 1998, Serum concentration of copper and zinc in patients with silicosis.J, Occup Health, 230
- Tiwari, 2005, Serum angiotensin converting enzyme activity and serum copper levels in convert silicosis, Indian J Occup Environ Med, 124
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Cheng, Y., Luo, W., Li, Z., Cao, M., Zhu, Z., Han, C., Dai, X., Zhang, W., Wang, J., Yao, H., et al. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0017oc · Cited by 70
Liang, D., Wang, Y., Zhu, Z., Yang, G., An, G., Li, X., Niu, P., Chen, L., & Tian, L. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.11.012 · Cited by 57
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Jalali, M., Sakhvidi, M. J. Z., Bahrami, A., Berijani, N., & Mahjub, H. (2016) · PubMed Central · Cited by 34
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Ehrlich, R. I., Murray, J., & Rees, D. (2018) · American Journal of Industrial Medicine · doi:10.1002/ajim.22909 · Cited by 32
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Chan, J. Y., Tsui, J. C. C., Law, P. T. W., So, W. K. W., Leung, D. Y. P., Sham, M. M. K., Tsui, S. K., & Chan, C. W. H. (2017) · Toxicology · doi:10.1016/j.tox.2017.11.001 · Cited by 24
Evaluation of oxysterol levels of patients with silicosis by LC–MS/MS method
Aksu, N., Samadi, A., Yalçınkaya, A. S., Çetin, T., Eser, B., Lay, İ., Öziş, T. N., Öztaş, Y., & Sabuncuoğlu, S. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03706-w · Cited by 24
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Upaassana, V. T., Ghosh, S., Chakraborty, A., Birch, M. E., Joseph, P., Han, J., Ku, B. K., & Ahn, C. H. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00582 · Cited by 23
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Metadata
- Authors
- Pandey, J., & Agarwal, D.
- Affiliations
- Central Institute of Mining and Fuel Research (IN)
- Venue
- Indian Journal of Occupational and Environmental Medicine
- Publisher
- Medknow
- Published
- 2012
- Volume
- 16
- Issue
- 3
- Pages
- 101
- ISSN
- 0019-5278 (ISSN-L)
- 0973-2284
- PMC
- PMC3683176
- OpenAlex
- W2078181637
- Cited by
- 47
- References
- 19
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2013: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Occupational and Environmental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- CSIR-Central Institute of Mining and Fuel Research
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Physical Sciences › Engineering › Safety, Risk, Reliability and Quality › Industrial and Mining Safety
- Keywords
- silicosis, biomarkers, prognostic factors, pneumoconiosis, silica exposure, occupational dust exposure, pulmonary fibrosis, early diagnosis, serum biomarkers
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