Mycobacterial culture of fine needle aspirate-A useful tool in diagnosing tuberculous lymphadenitis
Open accessAbstract
A prospective study was undertaken on suspected lymph node TB (LNTB) patients, to evaluate the diagnostic utility of mycobacterial culture of fine needle aspirate (FNA), in comparison with the cytological examination and acid fast staining. Eighty percent of 157 aspirates studied were positive by cytological examination; 18% by ZN smear and 45% were positive by culture. Twelve aspirates which were negative by cytological features yielded positive mycobacterial cultures; four out of these were from HIV positive patients. Our observations suggest that supplementing FNA cytology with mycobacterial culture would increase the sensitivity of diagnosing LNTB; in addition to giving a highly specific diagnosis.
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TBLN diagnosis mostly relies on cytology, but cytology is not bacteriological detection and is based on cell morphology changes; its specificity is confounded by other inflammatory reactions.
“TBLN diagnosis mostly re1lies on cytology but it is not bacteriological detection and based on cell morphology changes; its specificity is confounded by other inflammatory reactions [26].”
From Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis (2019) · cites this paper as [26]
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Iwnetu, R., van den Hombergh, J., Woldeamanuel, Y., Asfaw, M., Gebrekirstos, C., Negussie, Y., Bekele, T., Ashenafi, S., Seyoum, B., Melaku, K., et al. (2009) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540902897697 · Cited by 53 · see citing works
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Diagnosis of tuberculous lymphadenitis using fine needle aspiration biopsy
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- Authors
- Aparna, S., Prasad, C., Srinivas, A., Triveni, B., Gokhale, S., Krishna Moorthy, K., & Kishore Reddy, V.
- Affiliations
- Lepra Society (IN)
- Osmania Medical College (IN)
- Kasturba Medical College, Manipal (IN)
- Venue
- Indian Journal of Medical Microbiology
- Publisher
- Elsevier BV
- Published
- 2008
- Volume
- 26
- Issue
- 3
- Pages
- 259
- ISSN
- 0255-0857 (ISSN-L)
- OpenAlex
- W2020887223
- Cited by
- 17
- References
- 6
- Citations by year
- 2023: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2012: 5
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Indian Journal of Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Bioline International (Bioline International) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Lymphadenopathy Diagnosis and Analysis
- Keywords
- tuberculous lymphadenitis, mycobacterial culture, fine needle aspirate, cytology, acid-fast staining, diagnostic sensitivity, people living with HIV
- MeSH terms
- Humans, Mycobacterium, Prospective Studies, Sensitivity and Specificity, Tuberculosis, Lymph Node, HIV Infections, Biopsy, Fine-Needle
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