Differential Innervation of Secretory Coils and Ducts in Human Eccrine Sweat Glands
Open accessAbstract
BACKGROUND: Previous studies demonstrate that eccrine sweat glands are innervated by both cholinergic and adrenergic nerves. However, it is still unknown whether the secretory coils and ducts of eccrine sweat glands are equally innervated by the sympathetic nerve fibers. To well understand the mechanisms on sweat secretion and reabsorption, the differential innervation of secretory coils and ducts in human eccrine sweat glands was investigated in the study. METHODS: From June 2016 to June 2017, six human skins were fixed, paraffin-embedded, and cut into 5 μm-thick sections, followed by costaining for nerve fiber markers protein gene product 9.5 (PGP 9.5), tyrosine hydroxylase (TH) and vasoactive intestinal peptide (VIP), and eccrine sweat gland markers K7, S100P, and K14 by combining standard immunofluorescence with tyramide signal amplification (IF-TSA). Stained sections were observed under the microscope, photographed, and analyzed. RESULTS: The fluorescent signals of PGP 9.5, TH, and VIP were easily visualized, by IF-TSA, as circular patterns surrounding eccrine sweat glands, but only PGP 9.5 could be observed by standard IF. The IF-TSA method is more sensitivity than standard IF in detecting antigens expressed at low levels. PGP 9.5, TH, and VIP appeared primarily surrounding the secretory coils and sparsely surrounding the sweat ducts. CONCLUSION: Sweat secretion is mainly controlled by autonomic nerves whereas sweat reabsorption is less affected by nerve activity.
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The lumen structure in EGOs is similar to the primary structure of sweat gland ducts in body development.
“Therefore, we can infer that the lumen structure in our EGOs is similar to the primary structure of sweat gland ducts in body development.”
From Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids (2022) · cites this paper as [19]
The Introduction and Results distinguish sweat gland ducts from secretory coils and examine their innervation, but do not compare EGO lumens with ducts during development. Searches for lumen structure, organoids, and developmental duct structure found no passage addressing that comparison. (LLM, conf=0.75)
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Research works printed but not linked: 20
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Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids
Du, L., Zhang, L., Zhao, J., Chen, Z., Liu, X., Cao, M., You, L., Zhang, Y., Fu, X., & Li, H. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001936 · Cited by 6 · see citing works
Self-citation
- Authors
- Ouyang, Z., Li, H.-H., Zhang, M.-J., Xie, S.-T., & Cheng, L.-H.-H.
- Affiliations
- Shantou University Medical College (CN)
- Venue
- Chinese Medical Journal
- Published
- 2018-08-20
- Volume
- 131
- Issue
- 16
- Pages
- 1964-1968
- ISSN
- 0366-6999 (ISSN-L)
- PMC
- PMC6085860
- OpenAlex
- W2886308420
- Cited by
- 7
- References
- 0
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Chinese Medical Journal (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Keywords
- eccrine sweat glands, sweat gland innervation, sweat ducts, sympathetic nerve fibers, cholinergic nerves, adrenergic nerves, sweat secretion, tyrosine hydroxylase, vasoactive intestinal peptide, PGP 9.5, tyramide signal amplification, human skin
- MeSH terms
- Eccrine Glands, Fluorescent Antibody Technique, Humans, Nerve Fibers, Sweat Glands, Vasoactive Intestinal Peptide
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