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Cited by 6Oral microbiology and periodontitis researchDental Health and Care UtilizationDental materials and restorations

Evaluation of chemokines in gingival crevicular fluid in children with dental caries and stainless steel crowns: A clinico-biochemical study

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Kumar, NaveenKommineni, Reddy, VeeraKishore Kasa, Padakandla, Prathyusha, Togaru, Harshini, Kalagatla, Swathi, Chandra, SarathN·2016·Journal of Indian Society of Pedodontics and Preventive Dentistry
DOI 10.4103/0970-4388.186754
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Abstract

AIMS AND OBJECTIVES: The study was conducted to detect the presence of macrophage inflammatory protein-1α (MIP-1α) and MIP-1β and estimate their levels in gingival crevicular fluid (GCF) in children with dental caries and stainless steel crowns. MATERIALS AND METHODS: A total of 80 children with primary dentition were selected and categorized into four groups with twenty in each group; Group 1 - healthy subjects, Group 2 - dental caries, Group 3 - dental caries involving the pulp, and Group 4 - stainless steel crowns. GCF samples were collected by an extra-crevicular method with microcapillary pipettes. The GCF samples were quantified by ELISA and the levels of MIP-1α and MIP-1β were determined. RESULTS: MIP-1α and MIP-1β were detected in all the samples. Highest mean concentration in GCF was obtained for Group 3 followed by Groups 2 and 4 while the lowest concentration was seen in Group 1. This suggests that MIP-1α and MIP-1β levels in GCF increased proportionately with the inflammation. CONCLUSIONS: GCF serves as a noninvasive diagnostic fluid to measure biomarkers released during dental caries initiation and progression. MIP-1α and MIP-1β chemokines can be considered as novel biomarkers, in biological mechanism underlying the pathogenesis and inflammation in children with dental caries and stainless steel crowns.

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  • A variety of inflammatory mediators such as IL-1α, TNF-α, IL-1β, IL-6, MIP-1, IL-8, IL-1ra, CRP, PGE2 and IgG have been used to gain insight into the inflammatory response as a consequence of the use of different prosthetic restorative materials.

    “A variety of inflammatory mediators such as IL-1α, TNF-α, IL-1β, IL-6, MIP-1, IL-8, IL-1ra, CRP, PGE2 and IgG have been used to gain insight into the inflammatory response as a consequence of the use of different prosthetic restorative materials [27,28,29,30,31,32,33,34,36,37,38,39,40,41]”

    From Potential Impact of Prosthetic Biomaterials on the Periodontium: A Comprehensive Review (2023) · cites this paper as [30]

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Authors
Kumar, N., Reddy, V. K., Padakandla, P., Togaru, H., Kalagatla, S., & Chandra, S.
Venue
Journal of Indian Society of Pedodontics and Preventive Dentistry
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016
Volume
34
Issue
3
Pages
273
ISSN
0970-4388 (ISSN-L)
DOI
10.4103/0970-4388.186754
OpenAlex
W2479724078
Cited by
6
References
27
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2019: 1 · 2018: 1
FWCI
0.99
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Journal of Indian Society of Pedodontics and Preventive Dentistry (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
  • Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
Keywords
gingival crevicular fluid, chemokines, macrophage inflammatory protein-1alpha, MIP-1β, dental caries, stainless steel crowns, primary teeth, pulp involvement, biomarkers, gingivitis, children
MeSH terms
Child, Preschool, Crowns, Dental Caries, Enzyme-Linked Immunosorbent Assay, Female, Gingival Crevicular Fluid, Humans, Male, Stainless Steel, Case-Control Studies, Chemokines, Chemokine CCL3, Chemokine CCL4

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