Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis
Open accessAbstract
OBJECTIVES: To explore the effect of vitamin D supplementation in prevention of respiratory tract infections on the basis of published clinical trials. MATERIALS AND METHODS: Clinical trials were searched from various electronic databases. Five clinical trials were suitable for inclusion. Outcome was events of respiratory tract infections in vitamin D group and placebo group. Data was reported as odds ratio with 95% confidence interval. Both random and fixed model was used for analysis. Analysis was done with the help of Comprehensive meta-analysis software 2. RESULTS: Events of respiratory tract infections were significantly lower in vitamin D group as compared to control group [Odds ratio = 0.582 (0.417 - 0.812) P = 0.001] according to random model. Results were similar in fixed model. On separate analysis of clinical trials dealing with groups of children and adults, beneficial effect of vitamin D was observed in both, according to fixed model [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.653 (0.472 - 0.9040, P = 0.010 respectively]. On using random model beneficial effect persisted in children's group but became nonsignificant in adults group [Odds ratio = 0.579 (0.416 - 0.805), P = 0.001 and Odd ratio = 0.544 (0.278 - 1.063) P = 0.075 respectively]. CONCLUSION: Vitamin D supplementation decreases the events related to respiratory tract infections. There is need of more well conducted clinical trials to reach to a certain conclusion.
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Supplementation with vitamin D can protect against respiratory tract infections and reduce the risk of acute respiratory illness and influenza, especially with once-daily dosing.
“Supplementation with vitamin D can protect against respiratory tract infections and reduce the risk of acute respiratory illness and influenza, especially with once-daily dosing [112,113,114,115].”
From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [113]
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- Authors
- Charan, J., Goyal, J., Saxena, D., & Yadav, P.
- Corresponding author
- Charan, Jaykaran
- Venue
- Journal of Pharmacology and Pharmacotherapeutics
- Publisher
- SAGE Publications
- Published
- 2012
- Volume
- 3
- Issue
- 4
- Pages
- 300
- ISSN
- 0976-500X (ISSN-L)
- PMC
- PMC3543548
- OpenAlex
- W2167211900
- Cited by
- 228
- References
- 21
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 13 · 2023: 11 · 2022: 19 · 2021: 46 · 2020: 53 · 2019: 15 · 2018: 9 · 2017: 16 · 2016: 16 · 2015: 5 · 2014: 8 · 2013: 8
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- Journal of Pharmacology and Pharmacotherapeutics (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Keywords
- vitamin D supplementation, respiratory infections, infection control, children, adults, vitamin D deficiency
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