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Cited by 71Axon Guidance and Neuronal SignalingPesticide Exposure and ToxicityParkinson's Disease Mechanisms and Treatments

Neurotoxicity of the Pesticide Rotenone on Neuronal Polarization: A Mechanistic Approach

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Bisbal, Mariano, Sanchez, Mónica·2019·Neural Regeneration Research
DOI 10.4103/1673-5374.249847PMC PMC6375050
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Abstract

Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal development and it is maintained by complex subcellular mechanisms throughout cell life. A well-defined and controlled spatio-temporal program of cellular and molecular events strictly regulates the formation of the axon and dendrites from a non-polarized cell. This event is critical for an adequate neuronal wiring and therefore for the normal functioning of the nervous system. Neuronal polarity is very sensitive to the harmful effects of different factors present in the environment. In this regard, rotenone is a crystalline, colorless and odorless isoflavone used as insecticide, piscicide and broad spectrum pesticide commonly used earlier in agriculture. In the present review we will summarize the toxicity mechanism caused by this pesticide in different neuronal cell types, focusing on a particular biological mechanism whereby rotenone could impair neuronal polarization in cultured hippocampal neurons. Recent advances suggest that the inhibition of axonogenesis produced by rotenone could be related with its effect on microtubule dynamics, the actin cytoskeleton and their regulatory pathways, particularly affecting the small RhoGTPase RhoA. Unveiling the mechanism by which rotenone produces neurotoxicity will be instrumental to understand the cellular mechanisms involved in neurodegenerative diseases influenced by this environmental pollutant, which may lead to research focused on the design of new therapeutic strategies.

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Cited by

Sorted by citations

Authors
Bisbal, M., & Sanchez, M.
Affiliations
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Corresponding author
  • Bisbal, Mariano
  • Sanchez, Mónica
ORCID
Bisbal, Mariano
Venue
Neural Regeneration Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019
Volume
14
Issue
5
Pages
762
ISSN
1673-5374 (ISSN-L)
DOI
10.4103/1673-5374.249847
PMC
PMC6375050
OpenAlex
W2913717574
Cited by
71
References
1
Citations by year
2026: 3 · 2025: 13 · 2024: 14 · 2023: 8 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 1 · 2015: 1
FWCI
1.09
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Neural Regeneration Research (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
rotenone, neurotoxicity, neuronal polarity, axonogenesis, dendrite formation, microtubule dynamics, actin cytoskeleton, RhoA, hippocampal neurons, pesticide toxicity, neurodegenerative diseases, environmental pollutants

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