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Kaempferol and its derivatives: Biological activities and therapeutic potential

Parveen, Shazia, Bhat, Irshad Ul Haq, Bhat, Rajeev·2023·Asian Pacific Journal of Tropical Biomedicine
DOI 10.4103/2221-1691.387747
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Abstract

Kaempferol, a natural plant-origin flavonoid, exhibits therapeutic anti-inflammatory, antioxidant, anticancer, antidiabetic, and neuroprotective properties. Kaempferol acts within several distinct mechanisms like apoptotic induction in cancer cells, enzymatic inhibition, signalling pathway inhibition, and downregulation in cell viability during the G 2 /M phase of cell division. This review summarizes the therapeutic effects of kaempferol against several health ailments. The recent progress on kaempferol obtained from fruits and vegetables as an antioxidant, anti-inflammatory, anticancer, antidiabetic, and neuroprotective agent and its mechanisms of action are also discussed. In addition, kaempferol has been reported to be present in wastes and byproducts from post-fruit and vegetable processing. Thus, a paradigm shift towards valorizing fruits and vegetable industrial wastes/byproducts to obtain bioactive kaempferol can support the circular economy pillar for generating wealth from waste and for finding a sustainable alternative source.

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Metadata

Authors
Parveen, S., Bhat, I. U. H., & Bhat, R.
Venue
Asian Pacific Journal of Tropical Biomedicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2023-10
Volume
13
Issue
10
Pages
411-420
ISSN
  • 2221-1691
  • 2588-9222
DOI
10.4103/2221-1691.387747
Cited by
29
References
4
Language
en

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Parveen, S., Bhat, I. U. H., & Bhat, R. (2023). Kaempferol and its derivatives: Biological activities and therapeutic potential. Asian Pacific Journal of Tropical Biomedicine. https://doi.org/10.4103/2221-1691.387747