Kaempferol: A Key Emphasis to Its Anticancer Potential

The Role of Oxidative Stress in Carcinogenesis

Klaunig, J. E., & Kamendulis, L. M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121851 · Cited by 1,537 · see citing works

A Review on the Dietary Flavonoid Kaempferol

Calderón‐Montaño, J. M., Burgos‐Morón, E., Pérez‐Guerrero, C., & López‐Lázaro, M. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711795305335 · Cited by 1,391 · see citing works

Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity

Mira, L., Fernandez, M. T., Santos, M., Rocha, R., Florêncio, M. H., & Jennings, K. R. (2002) · Free Radical Research · doi:10.1080/1071576021000016463 · Cited by 1,055 · see citing works

In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves

Verma, A. R., Vijayakumar, M., Mathela, C. S., & Rao, C. V. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.06.005 · Cited by 499 · see citing works

Review: Dietary Flavonoids and Cancer Risk: Evidence From Human Population Studies

Neuhouser, M. L. (2004) · Nutrition and Cancer · doi:10.1207/s15327914nc5001_1 · Cited by 449 · see citing works

USDA Database for the Flavonoid Content of Selected Foods Release 3.1

Bhagwat, S. A., Haytowitz, D. B., & Holden, J. M. (2015) · Cited by 407 · see citing works

Distinctive Antioxidant and Antiinflammatory Effects of Flavonols

Wang, L., Tu, Y.-C., Lian, T.-W., Hung, J.-T., Yen, J.-H., & Wu, M. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0620719 · Cited by 391 · see citing works

Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Imran, M., Rauf, A., Shah, Z. A., Saeed, F., Imran, A., Arshad, M. U., Ahmad, B., Bawazeer, S., Atif, M., Peters, D. G., et al. (2018) · Phytotherapy Research · doi:10.1002/ptr.6227 · Cited by 341 · see citing works

Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups

Heijnen, C. G. M., Haenen, G. R. M. M., van Acker, F. A. A., van der Vijgh, W. J. F., & Bast, A. (2001) · Toxicology in Vitro · doi:10.1016/s0887-2333(00)00053-9 · Cited by 337 · see citing works

Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells

Chen, D., Daniel, K. G., Chen, M. S., Kuhn, D. J., Landis‐Piwowar, K. R., & Dou, Q. P. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.02.022 · Cited by 306 · see citing works

Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK111Abbreviations: CDK, cyclin-dependent kinase; CKI, CDK inhibitor; PI 3-kinase, phosphatidylinositol 3-kinase; PKC, protein kinase C; DTT, dithiothreitol; RIPA, radioimmunoprecipitation assay buffer.

Casagrande, F., & Darbon, J.-M. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00583-4 · Cited by 305 · see citing works

Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells

Kim, T. W., Lee, S. Y., Kim, M., Cheon, C., & Ko, S. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0930-1 · Cited by 305 · see citing works

Kaempferol, a potential cytostatic and cure for inflammatory disorders

Rajendran, P., Rengarajan, T., Nandakumar, N., Palaniswami, R., Nishigaki, Y., & Nishigaki, I. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.08.011 · Cited by 259 · see citing works

Antioxidants: Positive or Negative Actors?

Salehi, B., Martorell, M., Arbiser, J. L., Sureda, A., Martins, N. A., Maurya, P. K., Sharifi‐Rad, M., Kumar, P., & Sharifi‐Rad, J. (2018) · Biomolecules · doi:10.3390/biom8040124 · Cited by 259 · see citing works

Kaempferol induces apoptosis in glioblastoma cells through oxidative stress

Sharma, V., Joseph, C., Ghosh, S. K., Agarwal, A., Mishra, M. K., & Sen, E. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0788 · Cited by 244 · see citing works

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

Sharifi‐Rad, M., Fokou, P. V. T., Sharopov, F. S., Martorell, M., Ademiluyi, A. O., Rajković, J., Salehi, B., Martins, N. A., Iriti, M., & Sharifi‐Rad, J. (2018) · Molecules · doi:10.3390/molecules23071751 · Cited by 239 · see citing works

Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities

Weng, C., & Yen, G. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9347-y · Cited by 219 · see citing works

Inhibition of P-Glycoprotein Function and Expression by Kaempferol and Quercetin

Limtrakul, P., Khantamat, O., & Pintha, K. (2005) · Journal of Chemotherapy · doi:10.1179/joc.2005.17.1.86 · Cited by 209 · see citing works

Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans

DuPont, M. S., Day, A. J., Bennett, R. N., Mellon, F. A., & Kroon, P. A. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601916 · Cited by 206 · see citing works

Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats

Barve, A., Chen, C., Hebbar, V., Desiderio, J., Saw, C. L. L., & Kong, A. T. (2009) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.677 · Cited by 203 · see citing works

Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells

Luo, H., Rankin, G. O., Liu, L.-Z., Daddysman, M. K., Jiang, B., & Chen, Y. (2009) · Nutrition and Cancer · doi:10.1080/01635580802666281 · Cited by 195 · see citing works

Kaempferol Suppresses Proliferation and Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Breast Cancer Cells

Zhu, L., & Xue, L. (2018) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504018x15228018559434 · Cited by 193 · see citing works

Programmed Cell Death, from a Cancer Perspective: An Overview

Mishra, A. P., Salehi, B., Sharifi‐Rad, M., Pezzani, R., Kobarfard, F., Sharifi‐Rad, J., & Nigam, M. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0329-9 · Cited by 192 · see citing works

Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans

Kampkötter, A., Nkwonkam, C. G., Zurawski, R. F., Timpel, C., Chovolou, Y., Wätjen, W., & Kahl, R. (2007) · Archives of Toxicology · doi:10.1007/s00204-007-0215-4 · Cited by 190 · see citing works

Ginkgo biloba Extract Kaempferol Inhibits Cell Proliferation and Induces Apoptosis in Pancreatic Cancer Cells

Zhang, Y., Chen, A. Y., Li, M., Chen, C., & Yao, Q. C. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.02.036 · Cited by 179 · see citing works

Kaempferol‐induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK‐MAPK

Nguyen, T., Tran, E., Ong, C. K., et al. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10340 · Cited by 175 · see citing works

EXPRESSION OF CONCERN: Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction

Marfè, G., Tafani, M., Indelicato, M., Sinibaldi‐Salimei, P., Reali, V., Pucci, B., Fini, M., & Russo, M. A. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22044 · Cited by 174 · see citing works

Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways

Kashafi, E., Moradzadeh, M., Mohamadkhani, A., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.061 · Cited by 171 · see citing works

Complexation of Flavonoids with Iron: Structure and Optical Signatures

Ren, J., Meng, S., Lekka, C. E., & Kaxiras, E. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp076881e · Cited by 168 · see citing works

Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro

Lee, J., & Kim, J. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155264 · Cited by 163 · see citing works

Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria‐dependent pathway in human osteosarcoma U‐2 OS cells

Huang, W., Chiu, Y., Fan, M., et al. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000005 · Cited by 159 · see citing works

Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway

Luo, H., Rankin, G. O., Li, Z., DePriest, L., & Chen, Y. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.03.073 · Cited by 158 · see citing works

Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells

Liao, W., Chen, L., Ma, X., Jiao, R., Li, X., & Wang, Y. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.02.045 · Cited by 158 · see citing works

Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro

Colombo, M., Figueiró, F., de Fraga Dias, A., Teixeira, H. F., Battastini, A. M. O., & Koester, L. S. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.03.055 · Cited by 157 · see citing works

Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models

Kim, S., Hwang, K., & Choi, K. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.09.027 · Cited by 154 · see citing works

Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis

Yoshida, T., Konishi, M., Horinaka, M., Yasuda, T., Goda, A. E., Taniguchi, H., Yano, K., Wakada, M., & Sakai, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.131 · Cited by 150 · see citing works

Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells

Huang, W., Tsai, S., Peng, S., Lin, M., Chiang, J., Chiu, Y., Fushiya, S., Tseng, M. T., & Yang, J. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1909 · Cited by 149 · see citing works

The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake

Cao, J., Zhang, Y., Chen, W., & Zhao, X. (2009) · British Journal Of Nutrition · doi:10.1017/s000711450999170x · Cited by 148 · see citing works

Kaempferol Suppresses Transforming Growth Factor-β1–Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179

Jo, E., Park, S. J., Choi, Y. S., Jeon, W.-K., & Kim, B.-C. (2015) · Neoplasia · doi:10.1016/j.neo.2015.06.004 · Cited by 144 · see citing works

Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway

Diantini, A., Subarnas, A., Lestari, K., Halimah, E., Susilawati, Y., Supriyatna, S., Julaeha, E., Achmad, T. H., Suradji, E. W., Yamazaki, C., et al. (2012) · Oncology Letters · doi:10.3892/ol.2012.596 · Cited by 138 · see citing works

Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase‐3‐dependent apoptosis in oral cavity cancer cells

Kang, J. W., Kim, J. H., Song, K., Kim, S. H., Yoon, J., & Kim, K. S. (2009) · Phytotherapy Research · doi:10.1002/ptr.2913 · Cited by 137 · see citing works

Mechanisms Underlying Apoptosis-Inducing Effects of Kaempferol in HT-29 Human Colon Cancer Cells

Lee, H., Cho, H., Yu, R., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15022722 · Cited by 137 · see citing works

Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells

Choi, E. J., & Ahn, W. S. (2008) · Nutrition Research and Practice · doi:10.4162/nrp.2008.2.4.322 · Cited by 136 · see citing works

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

Riahi-Chebbi, I., Souid, S., Othman, H., Haoues, M., Karoui, H., Morel, A., Srairi‐Abid, N., Essafi, M., & Essafi‐Benkhadir, K. (2019) · Scientific Reports · doi:10.1038/s41598-018-36808-z · Cited by 136 · see citing works

Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes

Leung, H. W. C., Lin, C.-C., Hour, M. J., Yang, W., Wang, M.-Y., & Lee, M. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.04.023 · Cited by 135 · see citing works

The splanchnic metabolism of flavonoids highly differed according to the nature of the compound

Crespy, V., Morand, C., Besson, C., Cotelle, N., Vezin, H., Demigné, C., & Rémésy, C. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00223.2002 · Cited by 135 · see citing works

Kaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells

Lin, C., Chen, P., Chen, M., Yang, W., Tang, C., Yang, S., & Hsieh, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080883 · Cited by 134 · see citing works

The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake

Azevedo, C., Correia‐Branco, A., Araújo, J. R., Guimarães, J. T., Keating, E., & Martel, F. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1002625 · Cited by 125 · see citing works

Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells

Chen, H., Lin, C.-M., Lee, C., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2490 · Cited by 124 · see citing works

Nepeta species: From farm to food applications and phytotherapy

Salehi, B., Valussi, M., Jugran, A. K., Martorell, M., Ramírez‐Alarcón, K., Stojanović-Radić, Z. Z., Antolak, H., Kręgiel, D., Mileski, K. S., Sharifi‐Rad, M., et al. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.07.030 · Cited by 123 · see citing works

Measurement of xanthine oxidase inhibition activity of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method

Özyürek, M., Bektaşoğlu, B., Güçlü, K., & Apak, R. (2009) · Analytica Chimica Acta · doi:10.1016/j.aca.2009.01.037 · Cited by 120 · see citing works

Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc

Luo, H., Daddysman, M. K., Rankin, G. O., et al. (2010) · Cancer Cell International · doi:10.1186/1475-2867-10-16 · Cited by 119 · see citing works

A New View of Carcinogenesis and an Alternative Approach to Cancer Therapy

López‐Lázaro, M. (2009) · Molecular Medicine · doi:10.2119/molmed.2009.00162 · Cited by 119 · see citing works

The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions

Mylonis, I., Lakka, A., Tsakalof, A. K., & Simos, G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.038 · Cited by 118 · see citing works

Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells

Lee, G.-A., Choi, K., & Hwang, K. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.11.016 · Cited by 117 · see citing works

Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition

Kim, B., Lee, E.-R., Min, H.-M., et al. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.7.6164 · Cited by 116 · see citing works

Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9

Li, C., Zhao, Y., Yang, D., Yu, Y., Guo, H., Zhao, Z., Zhang, B., & Yin, X. (2014) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0067 · Cited by 114 · see citing works

Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study

SONG, H., Bao, J., Wei, Y., Chen, Y., MAO, X., LI, J., Yang, Z., & Xue, Y. (2014) · Oncology Reports · doi:10.3892/or.2014.3662 · Cited by 114 · see citing works

Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway

Luo, H., Rankin, G. O., Juliano, N., Jiang, B., & Chen, Y. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.07.045 · Cited by 107 · see citing works

Kaempferol Attenuates ROS-Induced Hemolysis and the Molecular Mechanism of Its Induction of Apoptosis on Bladder Cancer

Wu, P., Meng, X., Zheng, H., Zeng, Q., Chen, T., Wang, W., Zhang, X., & Su, J. (2018) · Molecules · doi:10.3390/molecules23102592 · Cited by 107 · see citing works

Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis

Dang, Q., Song, W., Xu, D., et al. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22154 · Cited by 106 · see citing works

Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells

Choi, J.-B., Kim, J., Lee, H., et al. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02656 · Cited by 106 · see citing works

Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats

Nirmala, P., & Ramanathan, M. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.11.034 · Cited by 105 · see citing works

Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis

Li, W., Du, B., Wang, T., et al. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.048 · Cited by 104 · see citing works

Kaempferol Induces Cell Death Through ERK and Akt-Dependent Down-Regulation of XIAP and Survivin in Human Glioma Cells

Jeong, J. C., Kim, M. S., Kim, T. H., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9868-5 · Cited by 103 · see citing works

Deconjugation and Degradation of Flavonol Glycosides by Pig Cecal Microbiota Characterized by Fluorescence in Situ Hybridization (FISH)

Hein, E., Rose, K., Slot, G. V., Friedrich, A. W., & Humpf, H. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073444o · Cited by 103 · see citing works

Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells

Cho, H., & Park, J. H. Y. (2013) · Journal of Cancer Prevention · doi:10.15430/jcp.2013.18.3.257 · Cited by 100 · see citing works

Kaempferol-7-O-β-d-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner

Xu, W., Liu, J., Li, C., Wu, H., & Yan-wen, L. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.01.044 · Cited by 99 · see citing works

Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways

Hung, T., Chen, P., Wu, H.-C., Wu, S., Tsai, P.-Y., Hsieh, Y., & Chang, H.-R. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.20336 · Cited by 98 · see citing works

The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin

Siegelin, M. D., Reuß, D., Habel, A., Herold‐Mende, C. C., & von Deimling, A. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0236 · Cited by 95 · see citing works

Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation

Lin, F., Luo, X., Tsun, A., Li, Z., Li, D., & Li, B. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.03.044 · Cited by 94 · see citing works

Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells

Hong, J.-T., Yen, J.-H., Wang, L., Lo, Y., Chen, Z., & Wu, M. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.02.014 · Cited by 93 · see citing works

In vitro and in vivo assessment of free radical scavenging and antioxidant activities of Veronica persica Poir

Sharifi‐Rad, J., Sharifi‐Rad, M., Salehi, B., Iriti, M., Roointan, A., Mnayer, D., Soltani‐Nejad, A., & Afshari, A. (2018) · Cellular and Molecular Biology · doi:10.14715/cmb/2018.64.8.9 · Cited by 93 · see citing works

The Bioflavonoid Kaempferol Is an Abcg2 Substrate and Inhibits Abcg2-Mediated Quercetin Efflux

An, G., Gallegos, J., & Morris, M. E. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.035212 · Cited by 92 · see citing works

Selective Cytotoxicity of Luteolin and Kaempferol on Cancerous Hepatocytes Obtained from Rat Model of Hepatocellular Carcinoma: Involvement of ROS-Mediated Mitochondrial Targeting

Seydi, E., Salimi, A., Rasekh, H. R., Mohsenifar, Z., & Pourahmad, J. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1460679 · Cited by 89 · see citing works

Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells

Sonoki, H., Tanimae, A., Endo, S., et al. (2017) · Nutrients · doi:10.3390/nu9060597 · Cited by 88 · see citing works

Kaempferol Modulates DNA Methylation and Downregulates DNMT3B in Bladder Cancer

Qiu, W., Lin, J., Zhu, Y., Zhang, J., Zeng, L., Su, M., & Tian, Y. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000464435 · Cited by 85 · see citing works

Low dose of kaempferol suppresses the migration and invasion of triple-negative breast cancer cells by downregulating the activities of RhoA and Rac1

Li, S., Yan, T., Deng, R., Jiang, X., Xiong, H., Wang, Y., Yu, Q., Wang, X., Chen, C., & Zhu, Y. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s140886 · Cited by 84 · see citing works

Soy Leaf Extract Containing Kaempferol Glycosides and Pheophorbides Improves Glucose Homeostasis by Enhancing Pancreatic β-Cell Function and Suppressing Hepatic Lipid Accumulation in db/db Mice

Li, H., Ji, H.-S., Kang, J., et al. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b01639 · Cited by 82 · see citing works

Structurally related flavonoids with antioxidative properties differentially affect cell cycle progression and apoptosis of human acute leukemia cells

Rusak, G., Gutzeit, H. O., & Müller, J. L. (2005) · Nutrition Research · doi:10.1016/j.nutres.2004.12.003 · Cited by 82 · see citing works

One-Pot Synthesis of Hyperoside by a Three-Enzyme Cascade Using a UDP-Galactose Regeneration System

Pei, J., Chen, A., Zhao, L., et al. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02320 · Cited by 82 · see citing works

The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: From macro to nano

Tu, L., Bai, H., Cai, J., & Deng, S. (2016) · Scanning · doi:10.1002/sca.21312 · Cited by 79 · see citing works

KAEMPFEROL, A FLAVONOID COMPOUND FROM GYNURA MEDICA INDUCED APOPTOSIS AND GROWTH INHIBITION IN MCF-7 BREAST CANCER CELL

Yi, X., Tan, C., Zuo, J., et al. (2016) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcam.v13i4.27 · Cited by 78 · see citing works

Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells

Oh, S. M., Kim, Y. P., & Chung, K. H. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02968584 · Cited by 76 · see citing works

Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN

Xie, F., Su, M., Qiu, W., Zhang, M., Guo, Z., Su, B., Liu, J., Li, X., & Zhou, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121215 · Cited by 75 · see citing works

Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells

Gao, Y., Yin, J., Rankin, G. O., et al. (2018) · Molecules · doi:10.3390/molecules23051095 · Cited by 74 · see citing works

High Intake of Specific Carotenoids and Flavonoids Does Not Reduce the Risk of Bladder Cancer

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Radiosensitization of non-small cell lung cancer by kaempferol

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Antioxidant RichMorus albaleaf Extract Induces Apoptosis in Human Colon and Breast Cancer Cells by the Downregulation of Nitric Oxide Produced by Inducible Nitric Oxide Synthase

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PGC1α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells

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Kaempferol 7-O-β-D-glucoside isolated from the leaves of Cudrania tricuspidata inhibits LPS-induced expression of pro-inflammatory mediators through inactivation of NF-κB, AP-1, and JAK-STAT in RAW 264.7 macrophages

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Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells

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Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway

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Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo

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Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling

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Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations

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Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells

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Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells

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Flavonol Glycosides of Sea Buckthorn (Hippophaë rhamnoides ssp. sinensis) and Lingonberry (Vaccinium vitis-idaea) Are Bioavailable in Humans and Monoglucuronidated for Excretion

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In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters

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A food pattern that is predictive of flavonol intake and risk of pancreatic cancer

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Structures of New Flavonoids and Benzofuran-Type Stilbene and Degranulation Inhibitors of Rat Basophilic Leukemia Cells from the Brazilian Herbal Medicine Cissus sicyoides

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Chemical Structure-Dependent Differential Effects of Flavonoids on the Catalase Activity as Evaluated by a Chemiluminescent Method

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Kaempferol Sensitizes Human Ovarian Cancer Cells-OVCAR-3 and SKOV-3 to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis via JNK/ERK-CHOP Pathway and Up-Regulation of Death Receptors 4 and 5

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Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells

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Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines

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Kaempferol Induces DNA Damage and Inhibits DNA Repair Associated Protein Expressions in Human Promyelocytic Leukemia HL-60 Cells

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Glucurono- and Sulfo-Conjugation of Kaempferol in Rat Liver Subcellular Preparations and Cultured Hepatocytes

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A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

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The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells

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Isolation from Eucalyptus occidentalis and Identification of a New Kaempferol Derivative that Induces Apoptosis in Human Myeloid Leukemia Cells

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Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC‐1)

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Kaempferol Activates G2-Checkpoint of the Cell Cycle Resulting in G2-Arrest and Mitochondria-Dependent Apoptosis in Human Acute Leukemia Jurkat T Cells

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Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets

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Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds

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Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry

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Impact of apigenin and kaempferol on human head and neck squamous cell carcinoma

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Urinary excretion of kaempferol from common beans (Phaseolus vulgarisL.) in humans

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6-Hydroxy-3- O -methyl-kaempferol 6- O -glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells

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Effects of Quercetin, Kaempferol, and Exogenous Glutathione on Phospho- and Total- AKT in 3T3-L1 Preadipocytes

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Isolation of phytoconstituents and evaluation of anticancer and Antioxidant potential of Launaea mucronata (Forssk.) Muschl. subsp.

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The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

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A Switch between Antioxidant and Prooxidant Properties of the Phenolic Compounds Myricetin, Morin, 3′,4′-Dihydroxyflavone, Taxifolin and 4-Hydroxy-Coumarin in the Presence of Copper(II) Ions: A Spectroscopic, Absorption Titration and DNA Damage Study

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Antioxidant vs. Prooxidant Properties of the Flavonoid, Kaempferol, in the Presence of Cu(II) Ions: A ROS-Scavenging Activity, Fenton Reaction and DNA Damage Study

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Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds

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Dietary phytochemicals targeting Nrf2 for chemoprevention in breast cancer

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20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells

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Probiotics for the Chemoprotective Role against the Toxic Effect of Cancer Chemotherapy

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Tuning the metabolism of the anticancer drug cisplatin with chemoprotective agents to improve its safety and efficacy

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Antiplatelet Agents for Cancer Prevention: Current Evidences and Continuing Controversies

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