The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The 1 μg cosyntropin test in normal individuals: A reappraisal
Open accessAbstract
BACKGROUND: The 1μg cosyntropin test has some advantages over the 250μg test as a test of adrenal function. One of the concerns regarding the 1 μg test includes stability of the cosyntropin when reconstituted and stored. Classically the 5(th) percentile responses to cosyntropin in normal individuals have been used to define a normal response. Recent studies have shown that these normative values should be determined for individual assays. MATERIALS AND METHODS: We performed a 1μg cosyntropin test using reconstituted and refrigerated (4-8(°) C) cosyntropin in saline solution in 49 non pregnant adults who were apparently healthy and had no exposure to exogenous glucocorticoids. The cosyntropin solution was stored for up to 60 days following reconstitution. We analysed the data for any association between duration of cosyntropin solution storage and the cortisol responses to cosyntropin administration. RESULTS: The mean ± SD cortisol level at baseline, 30 and 60 min were-12.19 ± 3 μg/dl, 20.72 ± 2.63 μg/dl, 16.86 ± 3.33 μg/dl. The 5(th) percentile cortisol response at 30 min was 16.5 μg/dl (16.33 μg/dl rounded off). The correlation coefficients between number of days of cosyntropin solution storage and the cortisol responses at 30 and 60 min were (Spear mans rho = 0.06,-0.24 respectively) (P = 0.69 and 0.41). There were no differences in cortisol values whether the storage was for less than 30 days or more than 30 days (mean difference 0.25 μg/dl P = 0.44). CONCLUSION: The 5(th) percentile normative values determined for our assay is lower than what is currently being used clinically and in research publications. Prolonged refrigerated storage of cosyntropin solution does not affect the validity of the 1 μg cosyntropin test.
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“Although dilution and storage of the lower concentrated solution may be regarded as critical, it is worth noting that diluted tetracosactide (in 0.9% saline at 1 g/mL) has been reported to be stable at 2-8°C for up to 60 days (60).”
From Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [60]
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Corticotropin tests for hypothalamic-pituitary- adrenal insufficiency: a metaanalysis
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The Low Dose ACTH Test--A Further Word of Caution
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- Nyunt, 2010, Normal Cortisol Response on Low-Dose Synacthen (1 μg) Test in Children with Prader Willi Syndrome, J Clin Endocrinol Metab, E464
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Cited by
Bornstein, S. R., Allolio, B., Arlt, W., Barthel, A., Don-Wauchope, A., Hammer, G. D., Husebye, E. S., Merke, D. P., Murad, M. H., Stratakis, C. A., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1710 · Cited by 1,769
Cortisol Concentrations in Well-Regulated Dogs with Hyperadrenocorticism Treated with Trilostane
Midence, J. N., Drobatz, K. J., & Hess, R. S. (2015) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.13615 · Cited by 19
Wagmode, N., Mathew, V., Bantwal, G., Ayyar, V. S., George, B., Patanjali, C., & Michael, J. (2018) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_114_18 · Cited by 13
Hypothalamic-Pituitary Adrenal Axis Status 3 Months After Recovery From COVID-19 Infection
Rashmi, K. G., Perumal, N. L., Cherian, A., Wyawahare, M., Prasad, A., Sahoo, J., Kamalanathan, S., Anusuya, R., & Naik, D. (2023) · Endocrine Research · doi:10.1080/07435800.2023.2245907 · Cited by 10
M., S. S. C., & Ramesh, J. (2023) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2022-0207 · Cited by 5
Metadata
- Authors
- Anantharaman, R., Menezes, G., Yusuf, R., Ganapathi, B., Ayyar, S., & Srinivasan, R.
- Affiliations
- St.John's Medical College Hospital (IN)
- Corresponding author
- Anantharaman, R
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2013
- Volume
- 17
- Issue
- 4
- Pages
- 693
- ISSN
- 2230-8210 (ISSN-L)
- PMC
- PMC3743372
- OpenAlex
- W2090670539
- Cited by
- 12
- References
- 15
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 1 · 2020: 2 · 2018: 1 · 2016: 1 · 2015: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- cortisol response, adrenal function testing, reference values, cold storage, healthy adults
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