Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency
Open accessAbstract
Fertility in women with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) appears to be reduced, especially in women with the classic salt-wasting type. Several factors have been suggested to contribute to this subfertility such as androgen excess, adrenal progesterone hypersecretion, consequences of genital reconstructive surgery, secondary polycystic ovaries syndrome, and psychosexual factors. In contrast to this subfertility, pregnancies are commonly normal and uneventful. Adequate glucocorticoid therapy and improvement of surgical and psychological management could contribute to optimize fertility in CAH female patients, even among women with the classic variant. This review provides current information regarding the reproductive outcomes of women with CAH due to 21-OHD and the fertility and pregnancy issues in this population.
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Increased progesterone can interfere with endometrial implantation.
“increased progesterone can interfere with endometrial implantation.108,109”
From Congenital adrenal hyperplasia (2017) · cites this paper as [109]
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References 38 · Cited by 22
- Authors
- Mnif, M. F., Kamoun, M., Kacem, F. H., Mnif, F., Charfi, N., Naceur, B. B., Rekik, N., & Abid, M.
- Affiliations
- Hopital Universitaire Hedi Chaker (TN)
- Corresponding author
- Kamoun, Mahdi
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2013-09
- Volume
- 17
- Issue
- 5
- Pages
- 790-793
- ISSN
- 2230-8210 (ISSN-L)
- 2230-9500
- PMC
- PMC3784860
- OpenAlex
- W1991869880
- Cited by
- 22
- References
- 38
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- congenital adrenal hyperplasia, 21-hydroxylase deficiency, female fertility, subfertility, pregnancy outcomes, hyperandrogenism, genital reconstructive surgery, polycystic ovary syndrome, glucocorticoid therapy, reproductive outcomes
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