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Glucocorticoid-induced myopathy: Pathophysiology, diagnosis, and treatment
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Glucocorticoid-induced myopathy is the most common type of drug-induced myopathy. Nearly 60% of patients with Cushing's syndrome have muscle weakness. Glucocorticoid-induced muscle atrophy affects mainly fast-twitch glycolytic muscle fibers (type IIb fibers). This brief review will discuss the pathophysiology behind glucocorticoid-induced myopathy, along with diagnostic features and treatment.
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“More than half of patients with Cushing’s syndrome (from exogenous or endogenous glucocorticoid excess) can develop muscle weakness.100”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [100]
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Metadata
- Authors
- Gupta, A., & Gupta, Y.
- Affiliations
- Government Medical College and Hospital (IN)
- Corresponding author
- Gupta, Yashdeep
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2013-09
- Volume
- 17
- Issue
- 5
- Pages
- 913-916
- ISSN
- 2230-8210 (ISSN-L)
- 2230-9500
- PMC
- PMC3784879
- OpenAlex
- W2054338937
- Cited by
- 202
- References
- 19
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 38 · 2023: 20 · 2022: 32 · 2021: 21 · 2020: 16 · 2019: 13 · 2018: 13 · 2017: 13 · 2016: 8 · 2015: 3 · 2014: 5
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- glucocorticoid-induced myopathy, drug-induced myopathy, Cushing's syndrome, muscle weakness, muscle atrophy, fast-twitch muscle, type IIb muscle fibers, pathophysiology, diagnosis, treatment
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