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Glucocorticoid-induced myopathy: Pathophysiology, diagnosis, and treatment
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Glucocorticoid-induced myopathy is the most common type of drug-induced myopathy. Nearly 60% of patients with Cushing's syndrome have muscle weakness. Glucocorticoid-induced muscle atrophy affects mainly fast-twitch glycolytic muscle fibers (type IIb fibers). This brief review will discuss the pathophysiology behind glucocorticoid-induced myopathy, along with diagnostic features and treatment.
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“More than half of patients with Cushing’s syndrome (from exogenous or endogenous glucocorticoid excess) can develop muscle weakness.100”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [100]
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Metadata
- Authors
- Gupta, A., & Gupta, Y.
- Affiliations
- Government Medical College and Hospital (IN)
- Corresponding author
- Gupta, Yashdeep
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2013-09
- Volume
- 17
- Issue
- 5
- Pages
- 913-916
- ISSN
- 2230-8210 (ISSN-L)
- 2230-9500
- PMC
- PMC3784879
- OpenAlex
- W2054338937
- Cited by
- 202
- References
- 19
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 38 · 2023: 20 · 2022: 32 · 2021: 21 · 2020: 16 · 2019: 13 · 2018: 13 · 2017: 13 · 2016: 8 · 2015: 3 · 2014: 5
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- glucocorticoid-induced myopathy, drug-induced myopathy, Cushing's syndrome, muscle weakness, muscle atrophy, fast-twitch muscle, type IIb muscle fibers, pathophysiology, diagnosis, treatment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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