Sleep in Thyrotoxicosis
Open accessAbstract
OBJECTIVE: Pattern of sleep in hyperthyroid state / thyrotoxicosis has not been systematically studied. It is being characterized as poor without further elaboration. We analyzed the pattern of sleep in a large sample of individuals with thyrotoxicosis who came to our endocrine center in southern India. MATERIALS AND METHODS: We identified individuals with the diagnosis of 'thyrotoxicosis' from our electronic medical record database, and evaluated clinical parameters and pattern of their sleep: difficulty in falling asleep (DFA), difficulty in maintaining sleep (DMS), excess daytime sleepiness). In the first phase, univariate analysis with logistic regression was performed. Multivariate logistic regression was performed in the next phase on variables with a P-value < 0.1: these were considered as potential categories/ variables. RESULTS: In model response variable with DFA, multivariate logistic regression predicted that subjects with abnormal appetite (more 1.7 or less 2.2), change in bowel motion (loose 1.5 or constipation 2.8), in mood (easy loss of temper 3.4), change of voice -- hoarse 7.4 or moderately hoarse 3.1), tended to have higher chances of difficulty in falling asleep (DFA). Patients with tremor (yes = 5.4) had greater likelihood of difficulty in maintaining sleep (DMS). CONCLUSIONS: Individuals with hyperthyroidism/thyrotoxicosis principally had difficulty in falling asleep DFA, which was related to hyperkinetic features.
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Sridhar et al. suggested that elevated levels of thyroid hormone were associated with several components of sleep dysfunction, including prolonged sleep latency, difficulty maintaining sleep, and excessive daytime sleepiness.
“Sridhar et al. (4) suggested that elevated levels of thyroid hormone were associated with several components of sleep dysfunction, including prolonged sleep latency, difficulty maintaining sleep, and excessive daytime sleepiness.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [4]
The Discussion reports associations between hyperkinetic features in patients with thyrotoxicosis and difficulty falling or staying asleep. The Results say patients with hand tremors were less likely to have excessive daytime sleepiness, rather than establishing the claimed association with that symptom. The cited passages concern diagnosed thyrotoxicosis and its features, not an association measured against thyroid hormone levels. (LLM, conf=0.86)
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- Authors
- Sridhar, G., Putcha, V., & Lakshmi, G.
- Affiliations
- Kasturba Medical College, Manipal (IN)
- ORCID
- Lakshmi, G
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2011
- Volume
- 15
- Issue
- 1
- Pages
- 23
- ISSN
- 2230-8210 (ISSN-L)
- PMC
- PMC3079865
- OpenAlex
- W2024722637
- Cited by
- 26
- References
- 13
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 3 · 2016: 3 · 2015: 1 · 2012: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- thyrotoxicosis, hyperthyroidism, sleep patterns, tremor, hoarseness, mood changes, appetite
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