The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Role of angiogenesis and angiogenic factors in acute and chronic wound healing
Open accessAbstract
Angiogenesis plays a crucial role in wound healing by forming new blood vessels from preexisting vessels by invading the wound clot and organizing into a microvascular network throughout the granulation tissue.This dynamic process is highly regulated by signals from both serum and the surrounding extracellular matrix environment.Vascular endothelial growth factor, angiopoietin, fibroblast growth factor and transforming growth factor-beta are among the potent angiogenic cytokines in wound angiogenesis.Specific endothelial cell ECM receptors are critical for morphogenetic changes in blood vessels during wound repair.In particular integrin (αvβ3) receptors for fibrin and fibronectin, appear to be required for wound angiogenesis: αvβ3 is focally expressed at the tips of angiogenic capillary sprouts invading the wound clot, and any functional inhibitors of αvβ3 such as monoclonal antibodies, cyclic RGD peptide antagonists, and peptidomimetics rapidly inhibit granulation tissue formation.In spite of clear knowledge about influence of many angiogenic factors on wound healing, little progress has been made in defining the source of these factors, the regulatory events involved in wound angiogenesis and in the clinical use of angiogenic stimulants to promote repair.
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Cites
The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520
Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00014.x · Cited by 1,463 · cited 1×
“[1‐4] Three to five days after tissue injury, new capillaries become visible in the wound bed as granulation tissue, which acts as a matrix for proliferating blood vessels, migrating fibroblasts and new collagen.[5] Impaired granulation is a hallmark of chronic wounds encountered with diabetes and venous or arterial i…”
BackgroundRegulation of angiogenesis: Wound healing as a model
EMING, S., BRACHVOGEL, B., ODORISIO, T., & KOCH, M. (2007) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2007.06.001 · Cited by 392
Cited by
Guan, Y., Niu, H., Liu, Z., Dang, Y., Shen, J., Zayed, M., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 631
Komi, D. E. A., Khomtchouk, K., & Santa Maria, P. L. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08729-w · Cited by 384
Refai, H., El-Gazar, A. A., Ragab, G. M., Hassan, D. H., Ahmed, O. S., Hussein, R. A., Shabana, S., Waffo-Téguo, P., Valls, J., Al-Mokaddem, A. K., et al. (2023) · Marine Drugs · doi:10.3390/md21030149 · Cited by 36
Serini, S., & Calviello, G. (2021) · Foods · doi:10.3390/foods10102306 · Cited by 14
Metadata
- Authors
- Kumar, P., Kumar, S., Udupa, E. P., Kumar, U., Rao, P., & Honnegowda, T.
- Venue
- Plastic and Aesthetic Research
- Publisher
- OAE Publishing Inc.
- Published
- 2015
- Volume
- 2
- Issue
- 5
- Pages
- 243
- ISSN
- 2347-9264 (ISSN-L)
- OpenAlex
- W2172778470
- Cited by
- 290
- References
- 5
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Kumar, P., Kumar, S., Udupa, E. P., Kumar, U., Rao, P., & Honnegowda, T. (2015). Role of angiogenesis and angiogenic factors in acute and chronic wound healing. Plastic and Aesthetic Research. https://doi.org/10.4103/2347-9264.165438
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