High-risk HPV prevalence estimates among older patients: implications for cervical cancer screening programs
Open accessAbstract
Background: Due to the heterogeneity of existing studies and wide range of human papilloma virus (HPV) prevalence in India, further research into the incidence of HR-HPV and its spectrum of genotypes is essential to develop screening policies. This study aimed to determine the incidence and demographic distribution of HR-HPV among cisgender female patients attending a tertiary care facility in North India. Materials and Methods: This study was conducted in the Department of Obstetrics and Gynaecology, SGRR Institute of Medical and Health Sciences, Dehradun, India. HPV-DNA test results of 653 female patients were assessed for HR-HPV positivity, genotyping, and age-based differences via Chi-square analysis. Results: Overall prevalence of HR-HPV was 4.90%, HPV-16 was 1.37%, HPV-18 was 0.76%, and HPV non-16,18 was 2.7%. In patients ≤ 50 years, prevalence of HPV-16 was 0.97%, HPV-18 was 0.38%, and HR-HPV non-16,18 was 2.71%. In patients > 50 years, prevalence of HPV-16 was 2.89%, HPV-18 was 2.17%, and HR-HPV non-16,18 was 2.89%. The difference in the prevalence of HPV-16,18 between patients ≤ and > 50 years was found to be highly statistically significant ( P = 0.007485). The difference in the prevalence of total HR-HPV between patients ≤ and > 50 years was not found to be statistically significant ( P = 0.059905). Conclusion: Our study’s finding of higher HR-HPV positivity rates in patients > 50 years emphasizes the need for continued HR-HPV-DNA-based screening of this cohort. With widespread use in post-menopausal patients, HPV screening can serve as an important armamentarium in the fight against cervical cancer.
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The HPV positivity prevalence aligns with regional estimates ranging between 5% and 15%.
“The HPV positivity prevalence aligns with regional estimates, ranging between 5% and 15%.2,16, 17, 18, 19, 20, 21”
From Integrating a “see-and-treat” approach with opportunistic human papilloma virus deoxyribonucleic acid (HPV DNA) based cervical cancer screening in India: a retrospective cross-sectional study (2026) · cites this paper as [17]
The Discussion reports several regional HPV prevalence estimates within 5%–15%, including 7.1% for Southern Asia and 9.9% for Eastern India. It does not establish 5%–15% as the regional range: the Introduction gives a wider range of 2.3%–36.9% for India, and the study's own estimate is 4.90%. (LLM, conf=0.82)
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- Authors
- Mittal, S., Kansal, Y., Singh, B., & Gupta, V.
- Affiliations
- Shri Guru Ram Rai Institute of Medical & Health Sciences (IN)
- Corresponding author
- Kansal, Yamini
- Venue
- Indian Journal of Community Medicine
- Published
- 2024-07
- Volume
- 49
- Issue
- 4
- Pages
- 599-603
- ISSN
- 0970-0218 (ISSN-L)
- 1998-3581
- PMC
- PMC11404415
- OpenAlex
- W4400570078
- Cited by
- 3
- References
- 18
- Citations by year
- 2026: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Community Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- high-risk HPV, HPV prevalence, cervical cancer screening, HPV genotyping, HPV16, HPV 18, older women, postmenopausal women, North India
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