ALDH1 & CD133 in invasive cervical carcinoma & their association with the outcome of chemoradiation therapy
Open accessAbstract
Background & objectives: Chemoradiation is the standard therapy for locally advanced invasive cervical cancer and response to treatment determines the outcome. Cancer stem cells (CSCs) and epithelial–mesenchymal transition (EMT) play a role in response to treatment and hence the aim of this study was to evaluate if their levels in pre-treatment biopsies by immunohistochemistry (IHC) could predict response to treatment and outcome. Methods: The study comprised 60 patients with FIGO Stage IIB/III invasive cervical carcinoma treated by chemoradiation. They were divided into two groups based on their clinical outcome: group 1, 30 patients who had no evidence of disease at 48 month follow up and group 2, 30 patients who had disease relapse within 6-12 months of treatment completion. IHC was performed for CSC markers (ALDH1, CD133, Nanog and Oct-4), EMT markers (E-cadherin and vimentin) and squamocolumnar junction (KRT7) markers and H-scores determined. Intergroup comparison was performed. The expression of these markers was also evaluated in histological sections of cervical pre-cancer (CIN1 and CIN3) in comparison to normal cervix. Results: Cervical Intraepithelial Neoplasia grade 3 (CIN3) showed high expression of ALDH1 and KRT7 as compared to normal cervical epithelium. Aldehyde dehydrogenase 1 (ALDH1) and CD133 were overexpressed in 70 and 24 per cent cervical carcinoma cases whereas E-cadherin showed reduced expression in invasive carcinoma as compared to normal controls. ALDH1 overexpression was significantly associated with disease relapse in invasive cervical carcinoma treated by chemoradiation (P<0.01). Interpretation & conclusions: Determination of ALDH1 levels in pre-treatment cervical biopsies of invasive cervical carcinoma may be useful for prediction of response to chemoradiation, with high levels predicting for a poor response.
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Some subtypes of Ehlers-Danlos syndrome have been associated with a pathogenic mutation in the ALB gene and weakly linked to ALDH1AI.
“Furthermore, some subtypes of Ehlers–Danlos syndrome have been associated with a pathogenic mutation in the ALB gene in ref. 42 and weakly linked to ALDH1AI in ref. 43.”
From A foundation model for clinician-centered drug repurposing (2024) · cites this paper as [43]
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- Authors
- Javed, S., Sood, S., Rai, B., Bhattacharyya, S., Bagga, R., & Srinivasan, R.
- Affiliations
- Post Graduate Institute of Medical Education and Research (IN)
- Corresponding author
- Srinivasan, Radhika
- Venue
- Indian Journal of Medical Research
- Publisher
- Scientific Scholar
- Published
- 2021-08
- Volume
- 154
- Issue
- 2
- Pages
- 367-374
- ISSN
- 0971-5916 (ISSN-L)
- PMC
- PMC9131751
- OpenAlex
- W4214710464
- Cited by
- 13
- References
- 36
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- The Indian Journal of Medical Research (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Keywords
- ALDH1, CD133, invasive cervical cancer, chemoradiotherapy, cancer stem cells, epithelial-mesenchymal transition, treatment response prediction, recurrence, E-cadherin, vimentin, keratin 7, squamocolumnar junction, cervical intraepithelial neoplasia, Nanog, Oct4, prognostic factors
- MeSH terms
- Aldehyde Dehydrogenase 1 Family, Uterine Cervical Neoplasms, Female, Humans, Isoenzymes, Recurrence, Biomarkers, Tumor, Cadherins, Retinal Dehydrogenase, Chemoradiotherapy
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