The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Adiponectin: Role in Physiology and Pathophysiology
Open accessAbstract
Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptors, AdipoR1 and AdipoR2. In addition, adiponectin is one of the hormones with the highest plasma concentrations. Weight loss or caloric restriction leads to increasing adiponectin levels, and this increase is associated with increased insulin sensitivity. Therefore, the adiponectin pathway can play a crucial role in the development of drugs to treat type 2 diabetes mellitus and other obesity-related diseases affected by insulin resistance like cancers or cardiovascular diseases. Adiponectin appears to increase insulin sensitivity by improving glucose and lipid metabolisms. The objective of this review is to analyze current knowledge concerning adiponectin and, in particular, its role in physiology and pathophysiology.
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Cites
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“They are topologically integral membrane proteins with intracellular N‐terminus and extracellular C‐terminus, which is the reverse topology of all other G‐protein coupled receptors.[28]”
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Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
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“In contrast, castrated male mice expressed significantly decreased ApN levels, while, in cell cultures, adding testosterone reduced both circulating ApN and ApN secretion.[63,65] This treatment also induces insulin resistance.”
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Rawat, P. S., Jaiswal, A., Khurana, A., Bhatti, J. S., & Navik, U. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111708 · Cited by 909
The effects of myosteatosis on skeletal muscle function in older adults
Dondero, K., Friedman, B., Rekant, J., Landers‐Ramos, R., & Addison, O. (2024) · Physiological Reports · doi:10.14814/phy2.16042 · Cited by 63
Theodorakis, N., Kreouzi, M., Pappas, A., & Nikolaou, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413438 · Cited by 43
Mączka, K., Stasiak, O., Przybysz, P., Grymowicz, M., & Smolarczyk, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179391 · Cited by 38
AdipoRon’s Impact on Alzheimer’s Disease—A Systematic Review and Meta-Analysis
Barbalho, S. M., Laurindo, L. F., de Oliveira Zanuso, B., da Silva, R. M. S., Gallerani Caglioni, L., Nunes Junqueira de Moraes, V. B. F., Fornari Laurindo, L., Dogani Rodrigues, V., da Silva Camarinha Oliveira, J., Beluce, M. E., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020484 · Cited by 18
Metadata
- Authors
- Nguyen, T. M. D.
- Venue
- International Journal of Preventive Medicine
- Published
- 2020-01
- Volume
- 11
- Issue
- 1
- Pages
- 136-136
- ISSN
- 2008-7802 (ISSN-L)
- 2008-8213
- OpenAlex
- W3083050368
- Cited by
- 366
- References
- 10
- FWCI
- 22.58
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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