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Evaluation of the Effect of Vitamin D Treatment on Cardiac Function in Non-Obese Female Adolescents with Vitamin D Deficiency in Türkiye: A Cross-Sectional Study

Altın, H, Şen, E, Bozdemir, ŞE, Türe, E, Aktürk, B, Karaca, A·2024·Nigerian Journal of Clinical Practice
DOI 10.4103/njcp.njcp_721_23
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Abstract

A BSTRACT: Background: Vitamin D deficiency may cause adverse effects on the cardiovascular system as well as many other systems. The risk of vitamin D deficiency increases during adolescence, when the growth rate is high, due to reasons such as limited sun exposure, inadequate dietary calcium, and vitamin D intake. Aim: To evaluate the effect of daily 2000 IU vitamin D supplementation for 12 weeks on cardiac function in non-obese adolescent girls with vitamin D deficiency. Methods: This cross-sectional study was carried out between September 2021 and June 2022. A total of 108 non-obese adolescent girls having 25-hydroxyvitamin D [25(OH)D] levels below 12 ng/mL were given daily 2000 IU vitamin D orally for 12 weeks. Serum levels of 25(OH)D, alkaline phosphatase, parathormone, calcium, phosphate, and cardiac function were determined before and after treatment. Results: After treatment, the 25(OH)D levels were above 20 ng/mL in 90.8% of the adolescents. The parathormone and alkaline phosphatase levels decreased, while the phosphate levels increased. Echocardiographic tissue Doppler studies showed positive changes in some systolic and diastolic function indicators. In addition, the myocardial performance index decreased from 0.42 ± 0.03 to 0.40 ± 0.03 ( P < 0.001) in the left ventricle, from 0.43 ± 0.03 to 0.38 ± 0.03 ( P < 0.001) in the right ventricle, and from 0.41 ± 0.04 to 0.38 ± 0.02 ( P < 0.001) in the interventricular septum after vitamin D treatment as compared to pretreatment. Conclusion: It was observed that administration of 2000 IU vitamin D treatment for a period of 12 weeks to non-obese adolescent girls with vitamin D deficiency contributed positively to cardiac systolic and diastolic function.

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Metadata

Authors
Altın, H., Şen, E., Bozdemir, Ş., Türe, E., Aktürk, B., & Karaca, A.
Affiliations
  • Department of Pediatric Cardiology, Bursa Medical Faculty, Bursa City Hospital, Bursa, Turkey
  • Department of Pediatrics, Bursa City Hospital, Bursa, Turkey
  • Department of Pediatric Infectious Diseases, Bursa Medical Faculty, Bursa City Hospital, Bursa, Turkey
  • Department of Pediatric Emergency Diseases, University of Healty Science, Bursa Medical Faculty, Bursa City Hospital, Bursa, Turkey
Venue
Nigerian Journal of Clinical Practice
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2024-02
Volume
27
Issue
2
Pages
194-201
ISSN
  • 1119-3077
  • 2229-7731
DOI
10.4103/njcp.njcp_721_23
Cited by
2
References
0
Language
en

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CoChat. (2026). Citation check: Evaluation of the Effect of Vitamin D Treatment on Cardiac Function in Non-Obese Female Adolescents with Vitamin D Deficiency in Türkiye: A Cross-Sectional Study. https://app.cochat.ai/papers/10.4103/njcp.njcp_721_23
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Altın, H., Şen, E., Bozdemir, Ş., Türe, E., Aktürk, B., & Karaca, A. (2024). Evaluation of the Effect of Vitamin D Treatment on Cardiac Function in Non-Obese Female Adolescents with Vitamin D Deficiency in Türkiye: A Cross-Sectional Study. Nigerian Journal of Clinical Practice. https://doi.org/10.4103/njcp.njcp_721_23

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