The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Molecular Differences and Similarities between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis
Abstract
Transgenic (Tg) mouse models of Alzheimer's disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid precursor protein (APP) mutations, was designed to rapidly recapitulate a portion of the pathologic alterations present in human AD. APP and its proteolytic peptides, as well as apolipoprotein E and endogenous mouse tau, were investigated in the 5XFAD mice at 3 months, 6 months, and 9 months. AD and nondemented subjects were used as a frame of reference. APP, amyloid-beta (Aβ) peptides, APP C-terminal fragments (CT99, CT83, AICD), β-site APP-cleaving enzyme, and APLP1 substantially increased with age in the brains of 5XFAD mice. Endogenous mouse tau did not show age-related differences. The rapid synthesis of Aβ and its impact on neuronal loss and neuroinflammation make the 5XFAD mice a desirable paradigm to model AD.
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“this is explained by increased expression of the Thy1 promoter used to drive the transgenes in this model which has an estrogen response element40,41 resulting in generation of higher levels of Aβ4,42.”
From Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease. (2021) · cites this paper as [42]
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Cited by
Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease.
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Updates on mouse models of Alzheimer’s disease
Zhong, M. Z., Peng, T., Duarte, M. L., Wang, M., & Cai, D. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00712-0 · Cited by 189
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Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model
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Metadata
- Authors
- Maarouf, C. L., Kokjohn, T. A., Whiteside, C. M., Macias, M. P., Kalback, W. M., Sabbagh, M. N., Beach, T. G., Vassar, R., & Roher, A. E.
- Affiliations
- The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute Sun City, AZ, USA.
- Roberts Clinical Center, Banner Sun Health Research Institute Sun City, AZ, USA.
- Harold Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA.
- Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
- Venue
- Biochemistry Insights
- Publisher
- SAGE Publications
- Published
- 2013-01
- Volume
- 6
- Pages
- BCI.S13025
- ISSN
- 1178-6264
- PMC
- PMC4154482
- Cited by
- 60
- References
- 64
- Language
- en
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
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