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Cited by 26Pharmacy and Medical PracticesPharmaceutical studies and practicesMedication Adherence and Compliance

Tablet Splitting: A Review of Weight and Content Uniformity Part 1 of a 2-Part Series. Next month: Table Splitting—A Review of the Clinical and Economic Outcomes and Patient Acceptance

Freeman, Maisha Kelly, White, Whitney, Iranikhah, Maryam·2012·The Consultant Pharmacist
DOI 10.4140/tcp.n.2012.341
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Abstract

Objective To describe the product integrity and ethical/ legal issues associated with tablet splitting. Data sources PubMed (1966-June 2011), International Pharmaceutical Abstract (1975-June 2011), and bibliographic searches were conducted. Study selection All studies that evaluated the weight/dose variations (N = 13) of split tablets were included. Data extraction The American Pharmacists Association guidelines, recommendations from the Food and Drug Administration, and clinical studies evaluating product integrity of split tablets were used to provide an overview of issues related to this practice. Legal considerations from various sources were also included. Data synthesis The practice of tablet splitting is increasing and is associated with variations in drug distributions related to the tablet-splitting technique and other causes. The first part of this two-part series will evaluate the product integrity and practice-related issues associated with tablet splitting. Conclusion The majority of the studies associated with tablet splitting reveal large fluctuations in weight/dosage, but few studies evaluate variability with narrow therapeutic index medications. Therefore, the clinical impact of these variations is not globally applicable across medication classes. Although tablet splitting has the potential to save patients and health care organizations a significant amount of money, appropriateness of tablet splitting should be determined for individual medications and indi…

Integrity signals

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Crossref · 10.4140/tcp.n.2012.341

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  • A review conducted in 2012 did not focus on a specific population, drug, or disease, but a meta-analysis was not undertaken and an update is needed.

    “A review conducted in 2012 did not focus on a specific population, drug, or disease, but a meta-analysis was not undertaken and an update is needed.15”

    From Does splitting a tablet obtain an accurate dose? A systematic review and meta‐ analysis (2022) · cites this paper as [15]

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Authors
Freeman, M. K., White, W., & Iranikhah, M.
Affiliations
Samford University (US)
Venue
The Consultant Pharmacist
Publisher
American Society of Consultant Pharmacists
Published
2012-05-01
Volume
27
Issue
5
Pages
341-352
ISSN
0888-5109 (ISSN-L)
DOI
10.4140/tcp.n.2012.341
OpenAlex
W2395012100
Cited by
26
References
25
Citations by year
2026: 4 · 2024: 1 · 2023: 1 · 2022: 7 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1
FWCI
0.17
Type
journal article
Language
en
Open access
closed
Locations
  • The Consultant Pharmacist (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Keywords
tablet splitting, drug content uniformity, product integrity, legal and ethical issues, drug cost savings, patient acceptance, FDA guidance
MeSH terms
Drug Stability, Drug Therapy, Pharmaceutical Preparations, Humans, Legislation, Drug, Patient Education as Topic, Tablets, United States, Drug Costs, Guidelines as Topic

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