Activity of Gallic Acid and Its Ester Derivatives in Caenorhabditis Elegans and Zebrafish (Danio Rerio) Models
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AIM: Gallic acid and its ester derivatives have shown antifungal activity in vitro. This study was performed to investigate their activity against Candida albicans and their toxicity in the animal models Caenorhabditis elegans and zebrafish embryos. RESULTS: The compounds protected worms from C. albicans infection. The dodecyl gallate was the most effective. In zebrafish embryo, gallic acid and dodecyl gallate were the least toxic. CONCLUSION: Gallic acid and its ester derivatives have potential for in vivo use against C. albicans infection. The antifungal effects and toxicity of gallate esters in these alternative animal models were dependent on carbon chain length.
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Gallic acid from banana peel has potential antifungal activity against four studied yeast of Candida spp.
“some reports observed that gallic acid from banana peel had potential antifungal activity against four studied yeast of Candida spp. [69–71]”
From Banana Peels: A Waste Treasure for Human Being (2022) · cites this paper as [71]
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- Authors
- Singulani, J. D. L., Scorzoni, L., Gomes, P. C., Nazaré, A. C., Polaquini, C. R., Regasini, L. O., Fusco-Almeida, A. M., & Mendes-Giannini, M. J. S.
- Affiliations
- Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University-UNESP, Araraquara, São Paulo, Brazil
- Universidade Estadual Paulista (Unesp) (BR)
- Department of Chemistry & Environmental Sciences, Institute of Biosciences, Humanities & Exact Sciences, São Paulo State University-UNESP, São José do Rio Preto, São Paulo, Brazil
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2017-10
- Volume
- 9
- Issue
- 16
- Pages
- 1863-1872
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- PMC
- PMC6077765
- OpenAlex
- W2766116658
- Cited by
- 33
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 1
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Future Medicinal Chemistry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Funders
- Caenorhabditis Genetics Center
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- gallic acid, gallate esters, dodecyl gallate, Candida albicans, antifungal activity, toxicity, Caenorhabditis elegans, zebrafish embryos, carbon chain length, fungal infection
- MeSH terms
- Amphotericin B, Animals, Antifungal Agents, Candida albicans, Esters, Gallic Acid, Humans, Structure-Activity Relationship, Zebrafish, Molecular Structure, Caenorhabditis elegans
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