Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., & Steitz, T. A. (1992) · Science · doi:10.1126/science.1377403 · Cited by 1,914 · see citing works

Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

Hazuda, D. J., Felock, P., Witmer, M., Wolfe, A., Stillmock, K., Grobler, J. A., Espeseth, A., Gabryelski, L., Schleif, W., Blau, C., et al. (2000) · Science · doi:10.1126/science.287.5453.646 · Cited by 1,131 · see citing works

Genome instability due to ribonucleotide incorporation into DNA

McElhinny, S. A. N., Kumar, D., Clark, A. B., Watt, D. L., Watts, B. E., Lundström, E.-B., Johansson, E., Chabes, A., & Kunkel, T. A. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.424 · Cited by 395 · see citing works

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Hazuda, D. J., Anthony, N. J., Gomez, R. P., Jolly, S. M., Wai, J. S. M., Zhuang, L., Fisher, T. E., Embrey, M. W., Guare, J. P., Egbertson, M. S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402357101 · Cited by 334 · see citing works

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds

Tomassini, J. E., Selnick, H. G., Davies, M. E. M., Armstrong, M. E., Baldwin, J. J., Bourgeois, M., Hastings, J. C., Hazuda, D. J., Lewis, J. A., & McClements, W. L. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.12.2827 · Cited by 188 · see citing works

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

Budihas, S. R. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki268 · Cited by 183 · see citing works

Point mutations in conserved amino acid residues within the C‐terminal domain of HIV‐1 reverse transcriptase specifically repress RNase H function

Schatz, O., Cromme, F. V., Grüninger-Leitch, F., & Grice, S. F. J. L. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81559-5 · Cited by 162 · see citing works

Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid

Shaw-Reid, C. A., Munshi, V., Graham, P., Wolfe, A. L., Witmer, M. V., Danzeisen, R. C., Olsen, D. B., Carroll, S. S., Embrey, M. W., Wai, J. S. M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200621200 · Cited by 156 · see citing works

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

Klumpp, K. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg881 · Cited by 151 · see citing works

Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors

Parkes, K. E. B., Ermert, P., Fässler, J., Ives, J. A. L., Martin, J. A., Merrett, J. H., Obrecht, D., Williams, G., & Klumpp, K. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm020334u · Cited by 147 · see citing works

Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2 H ,4 H )-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

Billamboz, M., Bailly, F., Lion, C. J., Touati, N., Vezin, H., Calmels, C., Andréola, M., Christ, F., Debyser, Z., & Cotelle, P. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm1014692 · Cited by 142 · see citing works

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

Himmel, D. M., Maegley, K. A., Pauly, T., Bauman, J. D., Das, K., Dharia, C., Clark, A. D., Ryan, K., Hickey, M. J., Love, R. A., et al. (2009) · Structure · doi:10.1016/j.str.2009.09.016 · Cited by 142 · see citing works

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

Himmel, D. M., Sarafianos, S. G., Dharmasena, S., Hossain, M. M., McCoy-Simandle, K., Ilina, T. V., Clark, A. D., Knight, J. L., Julias, J. G., Clark, P. K., et al. (2006) · ACS Chemical Biology · doi:10.1021/cb600303y · Cited by 141 · see citing works

6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro

Tramontano, E., Esposito, F., Badas, R., Santo, R. D., Costi, R., & Colla, P. L. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2004.11.002 · Cited by 120 · see citing works

Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2 H ,4 H )-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain

Billamboz, M., Bailly, F., Barreca, M. L., Luca, L. D., Mouscadet, J. F., Calmels, C., Andréola, M., Witvrouw, M., Christ, F., Debyser, Z., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8007085 · Cited by 119 · see citing works

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

Tavis, J. E., Cheng, X., Hu, Y., Totten, M., Cao, F., Michailidis, E., Aurora, R., Meyers, M. J., Jacobsen, E. J., Parniak, M. A., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003125 · Cited by 106 · see citing works

4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

Summa, V., Petrocchi, A., Matassa, V. G., Gardelli, C., Muraglia, E., Rowley, M., Paz, O. G., Laufer, R., Monteagudo, E. S., & Pace, P. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060854f · Cited by 103 · see citing works

RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information

Kirschberg, T. A., Balakrishnan, M., Squires, N. H., Barnes, T. L., Brendza, K. M., Chen, X., Eisenberg, E. J., Jin, W., Kutty, N., Leavitt, S. A., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900597q · Cited by 96 · see citing works

Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

Su, H.-P., Yan, Y., Prasad, G. S., Smith, R. F., Daniels, C. L., Abeywickrema, P. D., Reid, J. C., Loughran, H. M., Kornienko, M. A., Sharma, S. P., et al. (2010) · Journal of Virology · doi:10.1128/jvi.00353-10 · Cited by 95 · see citing works

Inhibition of the Ribonuclease H and DNA Polymerase Activities of HIV-1 Reverse Transcriptase by N -(4- tert -Butylbenzoyl)-2-hydroxy-1-naphthaldehyde Hydrazone

Borkow, G., Fletcher, R. S., Barnard, J. F., Arion, D., Motakis, D., Dmitrienko, G. I., & Parniak, M. A. (1997) · Biochemistry · doi:10.1021/bi9624696 · Cited by 91 · see citing works

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery, SAR, Modeling, and Mutagenesis

Koch, U., Attenni, B., Malancona, S., Colarusso, S., Conte, I., Filippo, M. D., Harper, S., Pacini, B., Giomini, C., Thomas, S., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051064t · Cited by 87 · see citing works

2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone

Costi, R., Santo, R. D., Artico, M., Massa, S., Ragno, R., Loddo, R., Colla, M. L., Tramontano, E., Colla, P. L., & Pani, A. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2003.10.005 · Cited by 83 · see citing works

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Chung, S., Himmel, D. M., Jiang, J.-K., Wojtak, K., Bauman, J. D., Rausch, J. W., Wilson, J. A., Beutler, J. A., Thomas, C. J., Arnold, E., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2000757 · Cited by 80 · see citing works

Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation

Lapkouski, M., Tian, L., Miller, J. T., Grice, S. F. J. L., & Yang, W. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2485 · Cited by 80 · see citing works

Recent Progress in the Design of Small Molecule Inhibitors of HIV RNase H

Klumpp, K., & Mirzadegan, T. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206776873653 · Cited by 77 · see citing works

Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase, RNase H, and Integrase Activities by Hydroxytropolones

Didierjean, J., Isel, C., Querré, F., Mouscadet, J. F., Aubertin, A.-M., Valnot, J., Piettre, S. R., & Marquet, R. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.12.4884-4894.2005 · Cited by 76 · see citing works

Dissecting the Effects of DNA Polymerase and Ribonuclease H Inhibitor Combinations on HIV-1 Reverse-Transcriptase Activities

Shaw-Reid, C. A., Feuston, B. P., Munshi, V., Getty, K. L., Krueger, J. A., Hazuda, D. J., Parniak, M. A., Miller, M. D., & Lewis, D. (2005) · Biochemistry · doi:10.1021/bi0486740 · Cited by 76 · see citing works

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N -Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

Lansdon, E. B., Liu, Q., Leavitt, S. A., Balakrishnan, M., Perry, J. K., Lancaster-Moyer, C., Kutty, N., Liu, X., Squires, N. H., Watkins, W. J., et al. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01594-10 · Cited by 75 · see citing works

Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise

Le Grice, S. F. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.389056 · Cited by 73 · see citing works

HIV-1 RT-Associated RNase H Function Inhibitors: Recent Advances in Drug Development

Tramontano, E., & Santo, R. D. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710792065045 · Cited by 68 · see citing works

Destabilization of the HIV-1 Reverse Transcriptase Dimer upon Interaction with N-Acyl Hydrazone Inhibitors

Sluis‐Cremer, N., Arion, D., & Parniak, M. A. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.2.398 · Cited by 67 · see citing works

Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach

Distinto, S., Esposito, F., Kirchmair, J., Cardia, M. C., Gaspari, M., Maccioni, E., Alcaro, S., Markt, P., Wolber, G., Zinzula, L., et al. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.01.056 · Cited by 63 · see citing works

2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4

Billamboz, M., Bailly, F., Lion, C. J., Calmels, C., Andréola, M., Witvrouw, M., Christ, F., Debyser, Z., Luca, L. D., Chimirri, A., et al. (2010) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2010.11.033 · Cited by 63 · see citing works

How Many Drugs Are Catecholics

Yang, D., Ji, H., Tang, G.-Y., Ren, W., & Zhang, H.-Y. (2007) · Molecules · doi:10.3390/12040878 · Cited by 63 · see citing works

Role of Residues in the Tryptophan Repeat Motif for HIV-1 Reverse Transcriptase Dimerization

Tachedjian, G., Aronson, H. G., Santos, M. D. L., Seehra, J., McCoy, J. M., & Goff, S. P. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01433-x · Cited by 62 · see citing works

Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity

Wendeler, M., Lee, H.-F., Bermingham, A., Miller, J. T., Chertov, O., Bona, M. K., Baichoo, N., Ehteshami, M., Beutler, J. A., O’Keefe, B. R., et al. (2008) · ACS Chemical Biology · doi:10.1021/cb8001039 · Cited by 60 · see citing works

Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold

Williams, P. D., Staas, D. D., Venkatraman, S., Loughran, H. M., Ruzek, R. D., Booth, T. M., Lyle, T. A., Wai, J. S. M., Vacca, J. P., Feuston, B. P., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.08.135 · Cited by 59 · see citing works

HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

Beilhartz, G. L., Wendeler, M., Baichoo, N., Rausch, J. W., Grice, S. F. J. L., & Götte, M. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.03.025 · Cited by 58 · see citing works

Preferential Inhibition of the Magnesium-Dependent Strand Transfer Reaction of HIV-1 Integrase by α-Hydroxytropolones

Semenova, E. A., Johnson, A. A., Marchand, C., Davis, D. A., Yarchoan, R., & Pommier, Y. G. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.020321 · Cited by 58 · see citing works

Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity

Ilina, T., LaBarge, K., Sarafianos, S. G., Ishima, R., & Parniak, M. A. (2012) · Biology · doi:10.3390/biology1030521 · Cited by 54 · see citing works

Monoaryl- and Bisaryldihydroxytropolones as Potent Inhibitors of Inositol Monophosphatase

Piettre, S. R., Catherine André, Chanal, M., Ducep, J., Lesur, B. M., Piriou, F., Raboisson, P., Rondeau, J., Schelcher, C., Zimmermann, P., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm9701942 · Cited by 54 · see citing works

Mutational Analysis of Tyr-501 of HIV-1 Reverse Transcriptase

Arion, D., Sluis‐Cremer, N., Min, K., Abram, M. E., Fletcher, R. S., & Parniak, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110254200 · Cited by 50 · see citing works

Interaction of HIV‐1 Reverse Transcriptase Ribonuclease H with an Acylhydrazone Inhibitor

Gong, Q., Menon, L., Ilina, T. V., Miller, L. G., Ahn, J., Parniak, M. A., & Ishima, R. (2010) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2010.01052.x · Cited by 44 · see citing works

Exploiting Drug-Resistant Enzymes as Tools To Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Masaoka, T., Chung, S., Caboni, P., Rausch, J. W., Wilson, J. A., Taskent‐Sezgin, H., Beutler, J. A., Tocco, G., & Grice, S. F. J. L. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400405z · Cited by 43 · see citing works

Inhibition of HIV-1 Reverse Transcriptase-Catalyzed DNA Strand Transfer Reactions by 4-Chlorophenylhydrazone of Mesoxalic Acid

Davis, W. R., Tomsho, J. W., Nikam, S. S., Cook, E. M., Somand, D. M., & Peliska, J. A. (2000) · Biochemistry · doi:10.1021/bi0015764 · Cited by 42 · see citing works

Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors

Distinto, S., Maccioni, E., Meleddu, R., Corona, A., Alcaro, S., & Tramontano, E. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319100009 · Cited by 42 · see citing works

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity

Suchaud, V., Bailly, F., Lion, C. J., Tramontano, E., Esposito, F., Corona, A., Christ, F., Debyser, Z., & Cotelle, P. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.04.096 · Cited by 40 · see citing works

Inhibition of HIV-1 Ribonuclease H Activity by Novel Frangula-Emodine Derivatives

Kharlamova, Т. V., Esposito, F., Zinzula, L., Giovanni, F., Cheng, Y., Ginger, E., & Tramontano, E. (2009) · Medicinal Chemistry · doi:10.2174/157340609789117840 · Cited by 40 · see citing works

Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies

Felts, A. K., LaBarge, K., Bauman, J. D., Patel, D. V., Himmel, D. M., Arnold, E., Parniak, M. A., & Levy, R. M. (2011) · Journal of Chemical Information and Modeling · doi:10.1021/ci200194w · Cited by 37 · see citing works

6-Aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays

Costi, R., Santo, R. D., Artico, M., Roux, A., Ragno, R., Massa, S., Tramontano, E., Colla, M. L., Loddo, R., Marongiu, M. E., et al. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.01.037 · Cited by 37 · see citing works

Alizarine derivatives as new dual inhibitors of the HIV‐1 reverse transcriptase‐associated DNA polymerase and RNase H activities effective also on the RNase H activity of non‐nucleoside resistant reverse transcriptases

Esposito, F., Kharlamova, Т. V., Distinto, S., Zinzula, L., Cheng, Y., Dutschman, G. E., Floris, G., Markt, P., Corona, A., & Tramontano, E. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08057.x · Cited by 36 · see citing works

Structural Basis of the Allosteric Inhibitor Interaction on the HIV‐1 Reverse Transcriptase RNase H Domain

Christen, M. T., Menon, L., Myshakina, N. S., Ahn, J., Parniak, M. A., & Ishima, R. (2012) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12010 · Cited by 35 · see citing works

Derivatives of 5-Nitro-furan-2-carboxylic Acid Carbamoylmethyl Ester Inhibit RNase H Activity Associated with HIV-1 Reverse Transcriptase

Fuji, H., Urano, E., Futahashi, Y., Hamatake, M., Tatsumi, J., Hoshino, T., Morikawa, Y., Yamamoto, N., & Komano, J. A. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801071m · Cited by 35 · see citing works

Dimerization of Human Immunodeficiency Virus Type 1 Reverse Transcriptase as an Antiviral Target

Srivastava, S., Sluis‐Cremer, N., & Tachedjian, G. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206776873590 · Cited by 30 · see citing works

Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase

Yanagita, H., Urano, E., Matsumoto, K., Ichikawa, R., Takaesu, Y., Ogata, M., Murakami, T., Wu, H., Chiba, J., Komano, J. A., et al. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.12.011 · Cited by 29 · see citing works

A novel mechanism for inhibition of HIV-1 reverse transcriptase

Skillman, A. G., Maurer, K. W., Roe, D. C., Stauber, M. J., EARGLE, D. H. J., Ewing, T. J. A., Muscate, A., Davioud–Charvet, E., Medaglia, M. V., Fisher, R. J., et al. (2002) · Bioorganic Chemistry · doi:10.1016/s0045-2068(02)00502-3 · Cited by 28 · see citing works

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity

Chung, S., Miller, J. T., Johnson, B. C., Hughes, S. H., & Grice, S. F. J. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.314781 · Cited by 23 · see citing works

Novel Mechanism of Inhibition of HIV-1 Reverse Transcriptase by a New Non-nucleoside Analog, KM-1

Wang, L. Z., Kenyon, G. L., & Johnson, K. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406241200 · Cited by 23 · see citing works

Synthesis of Naphthalenesulfonic Acid Small Molecules as Selective Inhibitors of the DNA Polymerase and Ribonuclease H Activities of HIV-1 Reverse Transcriptase

Mohan, P., Loya, S., Avidan, O., Verma, S. K., Dhindsa, G. S., Wong, M. F., Huang, P., Yashiro, M., Baba, M., & Hizi, A. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00042a004 · Cited by 23 · see citing works

Small molecule inhibitors of HIV RT Ribonuclease H

Grandi, M. J. D., Olson, M. W., Prashad, A. S., Bebernitz, G. A., Luckay, A., Mullen, S., Hu, Y., Krishnamurthy, G., Pitts, K. E., & O’Connell, J. F. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.10.043 · Cited by 23 · see citing works

Effects of New Quinizarin Derivatives on Both HCV NS5B RNA Polymerase and HIV-1 Reverse Transcriptase Associated Ribonuclease H Activities

Tramontano, E., Kharlamova, Т. V., Zinzula, L., & Esposito, F. (2011) · Journal of Chemotherapy · doi:10.1179/joc.2011.23.5.273 · Cited by 10 · see citing works

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

Vernekar, S. K. V., Liu, Z., Nagy, E., Miller, L. G., Kirby, K. A., Wilson, D. J., Kankanala, J., Sarafianos, S. G., Parniak, M. A., & Wang, Z. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501132s · Cited by 143 · see citing works

Antimicrobial Importance of Medicinal Plants in Nigeria

Ugboko, H. U., Nwinyi, O. C., Oranusi, S. U., Fatoki, T. H., & Omonhinmin, C. A. (2020) · The Scientific World JOURNAL · doi:10.1155/2020/7059323 · Cited by 130 · see citing works

Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication

Esposito, F., Carli, I., Vecchio, C. D., Xu, L., Corona, A., Grandi, N., Piano, D., Maccioni, E., Distinto, S., Parolin, C., et al. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.08.001 · Cited by 87 · see citing works

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

Xu, L., Grandi, N., Vecchio, C. D., Mandas, D., Corona, A., Piano, D., Esposito, F., Parolin, C., & Tramontano, E. (2015) · The Journal of Microbiology · doi:10.1007/s12275-015-4652-0 · Cited by 75 · see citing works

Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

Corona, A., Leva, F. S. D., Thierry, S., Pescatori, L., Crucitti, G. C., Subra, F., Delelis, O., Esposito, F., Rigogliuso, G., Costi, R., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03605-14 · Cited by 70 · see citing works

Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase

Sonar, V. P., Corona, A., Distinto, S., Maccioni, E., Meleddu, R., Fois, B., Floris, C., Malpure, N. V., Alcaro, S., Tramontano, E., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.02.054 · Cited by 62 · see citing works

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

Corona, A., Meleddu, R., Esposito, F., Distinto, S., Bianco, G., Masaoka, T., Maccioni, E., Menéndez‐Arias, L., Alcaro, S., Grice, S. F. J. L., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147225 · Cited by 58 · see citing works

Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication

Sanna, C., Scognamiglio, M., Fiorentino, A., Corona, A., Graziani, V., Caredda, A., Cortis, P., Montisci, M., Ceresola, E. R., Canducci, F., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195168 · Cited by 54 · see citing works

(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase

Meleddu, R., Distinto, S., Corona, A., Bianco, G., Cannas, V., Esposito, F., Artese, A., Alcaro, S., Mátyus, P., Bogdán, D., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.02.032 · Cited by 52 · see citing works

New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H

Corona, A., Leva, F. S. D., Rigogliuso, G., Pescatori, L., Madia, V. N., Subra, F., Delelis, O., Esposito, F., Cadeddu, M., Costi, R., et al. (2016) · Antiviral Research · doi:10.1016/j.antiviral.2016.09.008 · Cited by 44 · see citing works

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

Vernekar, S. K. V., Tang, J. Y., Wu, B., Huber, A. D., Casey, M. C., Myshakina, N. S., Wilson, D. J., Kankanala, J., Kirby, K. A., Parniak, M. A., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00440 · Cited by 44 · see citing works

Cutting into the substrate dominance: pharmacophore and structure-based approaches toward inhibiting human immunodeficiency virus reverse transcriptase-associated ribonuclease H

Wang, L., Sarafianos, S. G., & Wang, Z. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00450 · Cited by 43 · see citing works

Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase

Messore, A., Corona, A., Madia, V. N., Saccoliti, F., Tudino, V., Leo, A. D., Scipione, L., Vita, D. D., Amendola, G., Maro, S. D., et al. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00617 · Cited by 42 · see citing works

Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions

Corona, A., Onnis, V., Deplano, A., Bianco, G., Demurtas, M., Distinto, S., Cheng, Y., Alcaro, S., Esposito, F., & Tramontano, E. (2017) · Pathogens and Disease · doi:10.1093/femspd/ftx078 · Cited by 38 · see citing works

Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity

Esposito, F., Ambrosio, F. A., Maleddu, R., Costa, G., Rocca, R., Maccioni, E., Catalano, R., Romeo, I., Eleftheriou, P. T., Karia, D. C., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111617 · Cited by 37 · see citing works

Novel Antibiotics Targeting Bacterial Replicative DNA Polymerases

Santos, J. A., & Lamers, M. H. (2020) · Antibiotics · doi:10.3390/antibiotics9110776 · Cited by 36 · see citing works

Biological Activities of Aerial Parts Extracts ofEuphorbia characias

Pisano, M. B., Cosentino, S., Viale, S., Spanò, D., Corona, A., Esposito, F., Tramontano, E., Montoro, P., Tuberoso, C. I. G., Medda, R., et al. (2016) · BioMed Research International · doi:10.1155/2016/1538703 · Cited by 36 · see citing works

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

Carcelli, M., Rogolino, D., Gatti, A. M., Pala, N., Corona, A., Caredda, A., Tramontano, E., Pannecouque, C. C., Naesens, L. M. J., & Esposito, F. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00440 · Cited by 35 · see citing works

Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding

Martini, R., Esposito, F., Corona, A., Ferrarese, R., Ceresola, E. R., Visconti, L. M., Tintori, C., Barbieri, A., Calcaterra, A., Iovine, V., et al. (2016) · ChemBioChem · doi:10.1002/cbic.201600592 · Cited by 33 · see citing works

1,2,4-triazolo[1,5-a]pyrimidines as a novel class of inhibitors of the HIV-1 reverse transcriptase-associated ribonuclease H activity

Desantis, J., Massari, S., Corona, A., Astolfi, A., Sabatini, S., Manfroni, G., Palazzotti, D., Cecchetti, V., Pannecouque, C., Tramontano, E., et al. (2020) · Molecules · doi:10.3390/molecules25051183 · Cited by 29 · see citing works

Computational study on the interaction between CCR5 and HIV-1 entry inhibitor maraviroc: insight from accelerated molecular dynamics simulation and free energy calculation

Bai, Q., Zhang, Y., Li, X., Chen, W., Liu, H., & Yao, X. (2014) · Physical Chemistry Chemical Physics · doi:10.1039/c4cp03331k · Cited by 27 · see citing works

Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl)quinoline

Overacker, R. D., Banerjee, S., Neuhaus, G. F., Sephton, S. M., Herrmann, A., Strother, J. A., Brack‐Werner, R., Blakemore, P. R., & Loesgen, S. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.06.044 · Cited by 27 · see citing works

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors

Schneider, A., Corona, A., Spöring, I., Jordan, M. A., Buchholz, B. M., Maccioni, E., Santo, R. D., Bodem, J., Tramontano, E., & Wöhrl, B. M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw060 · Cited by 25 · see citing works

Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors

Esposito, F., Sechi, M., Pala, N., Sanna, A., Koneru, P. C., Kvaratskhelia, M., Naesens, L. M. J., Corona, A., Grandi, N., Santo, R. D., et al. (2019) · Antiviral Research · doi:10.1016/j.antiviral.2019.104671 · Cited by 23 · see citing works

Inhibition of HIV‐1 Reverse Transcriptase Dimerization by Small Molecules

Tintori, C., Corona, A., Esposito, F., Brai, A., Grandi, N., Ceresola, E. R., Clementi, M., Canducci, F., Tramontano, E., & Botta, M. (2016) · ChemBioChem · doi:10.1002/cbic.201500668 · Cited by 22 · see citing works

Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

Corona, A., Ballana, E., Distinto, S., Rogolino, D., Vecchio, C. D., Carcelli, M., Badía, R., Riveira‐Muñoz, E., Esposito, F., Parolin, C., et al. (2020) · Viruses · doi:10.3390/v12070729 · Cited by 22 · see citing works

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

Massari, S., Corona, A., Distinto, S., Desantis, J., Caredda, A., Sabatini, S., Manfroni, G., Felicetti, T., Cecchetti, V., Pannecouque, C. C., et al. (2018) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1523901 · Cited by 20 · see citing works

2-(Arylamino)-6-(trifluoromethyl)nicotinic acid derivatives: new HIV-1 RT dual inhibitors active on viral replication

Corona, A., Onnis, V., Del Vecchio, C., Esposito, F., Cheng, Y.-C., & Tramontano, E. (2020) · Molecules · doi:10.3390/molecules25061338 · Cited by 19 · see citing works

Triazolopyrimidine Nuclei: Privileged Scaffolds for Developing Antiviral Agents with a Proper Pharmacokinetic Profile

Felicetti, T., Pismataro, M. C., Cecchetti, V., Tabarrini, O., & Massari, S. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210526120534 · Cited by 19 · see citing works

Studies on Cycloheptathiophene‐3‐carboxamide Derivatives as Allosteric HIV‐1 Ribonuclease H Inhibitors

Corona, A., Desantis, J., Massari, S., Distinto, S., Masaoka, T., Sabatini, S., Esposito, F., Manfroni, G., Maccioni, E., Cecchetti, V., et al. (2016) · ChemMedChem · doi:10.1002/cmdc.201600015 · Cited by 19 · see citing works

Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H

Kang, J.-X., Zhao, G.-K., Yang, X., Huang, M.-X., Hui, W., Zeng, R., & Ouyang, Q. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115196 · Cited by 18 · see citing works

Can the Ever-Promising Target HIV Reverse Transcriptase-Associated RNase H Become a Success Story for Drug Development?

Corona, A., Esposito, F., & Tramontano, E. (2014) · Future Virology · doi:10.2217/fvl.14.24 · Cited by 18 · see citing works

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

Poongavanam, V., Corona, A., Steinmann, C., Scipione, L., Grandi, N., Pandolfi, F., Santo, R. D., Costi, R., Esposito, F., Tramontano, E., et al. (2018) · MedChemComm · doi:10.1039/c7md00600d · Cited by 17 · see citing works

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

Messore, A., Corona, A., Madia, V. N., Saccoliti, F., Tudino, V., Leo, A. D., Ialongo, D., Scipione, L., Vita, D. D., Amendola, G., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00535 · Cited by 17 · see citing works

Retroviral RNase H: structure, mechanism, and inhibition

(2021) · The Enzymes · doi:10.1016/bs.enz.2021.07.007 · Cited by 13 · see citing works

Herbal Medicine Methods and Practices in Nigeria

Iyiola, A. O., & Wahab, M. K. A. (2023) · Reference series in phytochemistry · doi:10.1007/978-3-031-21973-3_47-1 · Cited by 15 · see citing works

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities

Pala, N., Esposito, F., Rogolino, D., Carcelli, M., Sanna, V., Palomba, M., Naesens, L. M. J., Corona, A., Grandi, N., Tramontano, E., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081371 · Cited by 14 · see citing works

Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and Their Inhibition

Vanangamudi, M., Nair, P. C., Maida Engels, S. E., Senthilkumar, P., & Namasivayam, V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-16-0267-2_3 · Cited by 12 · see citing works

Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H

Tocco, G., Esposito, F., Caboni, P., Laus, A., Beutler, J. A., Wilson, J. A., Corona, A., Grice, S. F. J. L., & Tramontano, E. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1835884 · Cited by 11 · see citing works

Recent Advances in Computer-aided Antiviral Drug Design Targeting HIV-1 Integrase and Reverse Transcriptase Associated Ribonuclease H

Xue, W., Zhu, F., Yang, F., Yang, J., Zhang, Z., Tu, G., & Yao, X. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210708090123 · Cited by 11 · see citing works

Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata

Guzzo, F., Russo, R., Sanna, C., Celaj, O., Caredda, A., Corona, A., Tramontano, E., Fiorentino, A., Esposito, F., & D’Abrosca, B. (2021) · Molecules · doi:10.3390/molecules26164777 · Cited by 11 · see citing works

Search of antimicrobial activity in a series of substituted 4-aryl-4-oxo-2-tienilaminobut-2-enoic acids

Shipilovskikh, S. A., Махмудов, Р. Р., Balandina, S. Y., & Rubtsov, A. E. (2020) · AIP conference proceedings · doi:10.1063/5.0018494 · Cited by 10 · see citing works

Onopordum illyricum L., a Mediterranean plant, as a source of anti HIV-1 compounds

Sanna, C., Rigano, D., Cortis, P., Corona, A., Ballero, M., Parolin, C., Vecchio, C. D., Chianese, G., Saccon, E., Formisano, C., et al. (2018) · Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology · doi:10.1080/11263504.2018.1439118 · Cited by 10 · see citing works

A novel ultrasensitive RNase H assay based on phosphorothioated-terminal hairpin formation and self-priming extension reaction

Yoon, J., Lee, J., Kim, J., Lee, S. M., Kim, S., & Park, H. G. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116174 · Cited by 9 · see citing works

Herbal Medicine Methods and Practices in Nigeria

Iyiola, A. O., & Wahab, M. K. A. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-43199-9_47 · Cited by 9 · see citing works

Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors

Zhao, K., Zhang, Y., Wang, S., Wang, S., Corona, A., Maloccu, S., Tramontano, E., Pannecouque, C. C., Clercq, E. D., Meng, G., et al. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107495 · Cited by 9 · see citing works

Uvaria angolensis as a promising source of inhibitors of HIV-1 RT-associated RNA-dependent DNA polymerase and RNase H functions

Mfopa, A. N., Corona, A., Eloh, K., Tramontano, E., Frau, A., Boyom, F. F., Caboni, P., & Tocco, G. (2017) · Natural Product Research · doi:10.1080/14786419.2017.1332615 · Cited by 8 · see citing works

Rational Design, Synthesis, and Biological Evaluation of Novel Thiazole/Thiazolidinones Multitarget Anti-Human Immunodeficiency Virus Molecules

Tratrat, C., Petrou, A., Fesatidou, M., Haroun, M., Chohan, M., & Geronikaki, A. A. (2025) · Pharmaceuticals · doi:10.3390/ph18030298 · Cited by 6 · see citing works

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity

Tocco, G., Canton, S., Laus, A., Caboni, P., Grice, S. F. J. L., Tramontano, E., & Esposito, F. (2023) · Molecules · doi:10.3390/molecules28186700 · Cited by 3 · see citing works

Plus-strand RNA viruses hijack Musashi homolog 1 to shield viral RNA from cytoplasmic ribonuclease degradation

Zhou, D., Xu, M., Liu, Q., Xin, R., Cui, G., Ding, L., Liu, X., Zhang, X., Yan, T., Zhou, J., et al. (2025) · Journal of Virology · doi:10.1128/jvi.00023-25 · Cited by 2 · see citing works

Synthesis of catechols from cyclohexanones via acid-regulated dual oxidative transformations with TEMPO

Xu, B., Liu, X., Deng, L. M., Shang, Y., Jie, X., & Su, W. (2025) · Green Chemistry · doi:10.1039/d5gc00115c · Cited by 1 · see citing works

Studies Toward a General Synthesis of Poly-Substituted Alpha-Hydroxytropolones

Meck, C. (2015) · CUNY Academic Works (City University of New York)

1,4-Dihydroxy-1,8-napthyridinone (DHN) analogs as HIV-1 reverse transcriptase-associated RNase H inhibitors

Shahari, M. S. B., Offei, S., Zhang, H., Prahlad, J., Mahoney, J. P., Kirby, K. A., Sarafianos, S. G., & Wang, Z. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110119

BindingDB Entry 50008105: Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.

BindingDB (2021) · UC San Diego · doi:10.7270/q2nk3jdh

BindingDB Entry 50045688: Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.

BindingDB (2016) · UC San Diego · doi:10.7270/q2w95bwg

BindingDB Entry 7807: Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding.

BindingDB (2017) · UC San Diego · doi:10.7270/q2n29vs8

BindingDB Entry 50015637: Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.

BindingDB (2023) · UC San Diego · doi:10.7270/q2v98d1x

BindingDB Entry 50010624: Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.

BindingDB (2021) · UC San Diego · doi:10.7270/q2t1576w

BindingDB Entry 50007780: Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl)quinoline.

BindingDB (2021) · UC San Diego · doi:10.7270/q24m97w1

BindingDB Entry 7319: Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules.

BindingDB (2016) · UC San Diego · doi:10.7270/q25h7f28

BindingDB Entry 50045669: (3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase.

BindingDB (2016) · UC San Diego · doi:10.7270/q2bg2qpz

BindingDB Entry 50021230: Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H.

BindingDB (2025) · UC San Diego · doi:10.7270/q2mw2nq6

Characterization of the mechanism of action of new HIV-1 reverse transcriptase-associated ribonuclease H inhibitors

Corona, A. (2014) · VEprints - Universita degli Studi di Cagliari

Structural Basis of the Allosteric Inhibitor Interaction on the HIV‐1 Reverse Transcriptase RNase H Domain

Christen, M. T., Menon, L., Myshakina, N. S., Ahn, J., Parniak, M. A., & Ishima, R. (2012) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12010 · Cited by 35 · see citing works

HIV Ribonuclease H: Continuing the Search for Small Molecule Antagonists

Wendeler, M., Beilhartz, G. L., Beutler, J. A., Götte, M., & Grice, S. F. L. (2008) · HIV Therapy · doi:10.2217/17584310.3.1.39 · Cited by 3 · see citing works

Small-molecule Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function: Challenges and Recent Developments

Madia, V. N., Messore, A., Leo, A. D., Tudino, V., Pindinello, I., Saccoliti, F., Vita, D. D., Scipione, L., Costi, R., & Santo, R. D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210322164557 · Cited by 12 · see citing works

RNase H as the New Target for Designing Anti-HIV-1 Drugs: An Overview of Recent Research Progress

Zhao, K., & Meng, G. (2026) · Topics in medicinal chemistry · doi:10.1007/7355_2026_185