ACAT1/SOAT1 as a Therapeutic Target for Alzheimer's Disease
Open accessAbstract
Alzheimer's disease (AD) is the most common cause of dementia with no cure at present. Cholesterol metabolism is closely associated with AD at several stages. ACAT1 converts free cholesterol to cholesteryl esters, and plays important roles in cellular cholesterol homeostasis. Recent studies show that in a mouse model, blocking ACAT1 provides multiple beneficial effects on AD. Here we review the current evidence that implicates ACAT1 as a therapeutic target for AD. We also discuss the potential usage of various ACAT inhibitors currently available to treat AD.
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CE is upregulated in AD patient brain and various AD models, and its downregulation is protective in various AD models.
“based on its upregulation in AD patient brain and various AD models, along with the fact that its downregulation is protective in various AD models10,12,15,64.”
From Decreased lipidated ApoE‐receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes (2025) · cites this paper as [64]
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- Authors
- Shibuya, Y., Chang, C. C., & Chang, T.-Y.
- Affiliations
- Dartmouth College (US)
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2015-12
- Volume
- 7
- Issue
- 18
- Pages
- 2451-2467
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- PMC
- PMC4976859
- OpenAlex
- W2260642650
- Cited by
- 113
- References
- 25
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 24 · 2023: 11 · 2022: 13 · 2021: 10 · 2020: 16 · 2019: 11 · 2018: 5 · 2017: 4 · 2016: 2
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Future Medicinal Chemistry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AG37609)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- ACAT1, SOAT1, Alzheimer's disease, cholesterol metabolism, cholesteryl ester synthesis, cholesterol homeostasis, ACAT inhibitors, therapeutic target, mouse model
- MeSH terms
- Acetyl-CoA C-Acetyltransferase, Alzheimer Disease, Animals, Sterol O-Acyltransferase, Enzyme Inhibitors, Humans, Mice
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